New trials, publications, preprints and grants on this target, month by month.
Publication
MiR-326 targets ETS1 to activate PI3K/Akt signaling and promote malignant phenotypes in gastric cancer cells.
1 Dec 2026· Pakistan journal of pharmaceutical sciences· PUBMED
Publication
Modulation of G6PD-mediated Vitamin C Sensitivity in Small Cell Lung Cancer by the AKT/NRF2 axis.
5 Nov 2026· The Journal of biological chemistry· PUBMED
Publication
Statement of Retraction: MACC1 regulates the AKT/STAT3 signaling pathway to induce migration, invasion, cancer stemness, and suppress apoptosis in cervical cancer cells.
5 Nov 2026· Bioengineered· PUBMED
Publication
AKT is necessary for neuronal hypertrophy and epilepsy caused by Pten knockout.
4 Nov 2026· Brain : a journal of neurology· PUBMED
Publication
Targeting the PI3K/Akt/eNOS Pathway in Atherosclerosis: From Mechanotransduction to Emerging Therapies.
4 Nov 2026· The international journal of biochemistry & cell biology· PUBMED
Publication
Procyanidin B2 ameliorates osteoporosis by modulating osteoclast precursor differentiation through activation of the PI3K/Akt/Nrf2 axis.
4 Nov 2026· Bone· PUBMED
Publication
Characterization of cancer stem-like cells derived from a single 4T1 murine triple-negative breast cancer cell: Involvement of Akt‒mTOR pathway in the proliferation and sphere formation.
3 Nov 2026· Archives of biochemistry and biophysics· PUBMED
Publication
Exogenous tryptophan aggravates experimental lung fibrosis through activation of AKT-mTORC1 pathway.
3 Nov 2026· PloS one· PUBMED
Publication
Suppression of AKT Activation through LZK Inhibition Limits Tumor Growth in Esophageal and Head and Neck Cancers.
3 Nov 2026· Molecular cancer therapeutics· PUBMED
Publication
SALL4 drives gastric cancer progression through PI3K/Akt-mediated regulation of glycolysis, EMT, stemness, and adhesion remodeling.
1 Nov 2026· Biochimica et biophysica acta. Gene regulatory mechanisms· PUBMED
Publication
Epigenetic silencing of PDLIM4 promotes colorectal cancer by impairing BTF3 autophagic degradation and activating PI3K/Akt signalling.
1 Nov 2026· Clinical and translational medicine· PUBMED
Publication
Dendrobium officinale extract ameliorates Alzheimer's disease by modulating PI3K-AKT-mTOR pathway and autophagy-related processes: An integrated study combining feature-based molecular networking, network pharmacology and multi-omics.
31 Oct 2026· Journal of ethnopharmacology· PUBMED
Publication
Mucolipin TRP Cation Channel 1 Depletion Promotes Gastric Cancer Cell Ferroptosis Through the AKT Pathway.
31 Oct 2026· The Kaohsiung journal of medical sciences· PUBMED
Publication
SD-2102, a Novel PDK1 Inhibitor, Suppresses Lung Cancer Growth by Targeting PDK1/Akt Signaling Pathway.
30 Oct 2026· Biomolecules & therapeutics· PUBMED
Publication
SLC2A1 promotes chemo-immunotherapy resistance in lung adenocarcinoma by modulating the AKT signaling pathway.
28 Oct 2026· Functional & integrative genomics· PUBMED
Publication
AKT1-phosphorylated TERT assembles a FOXO3-MYC transcriptional complex that drives ERphagy and proteostasis in post-mitotic RPE.
26 Oct 2026· Autophagy· PUBMED
Publication
Hydroxysafflor yellow A ameliorates progression of endometriosis via regulating PPAR-γ/PTEN/Akt axis.
26 Oct 2026· Tissue & cell· PUBMED
Publication
Gentiopicroside suppresses cell proliferation, migration, and invasion via inhibition of the HGF/PI3K/Akt pathway in clear cell renal cell carcinoma.
26 Oct 2026· Acta pharmaceutica (Zagreb, Croatia)· PUBMED
Publication
UFSP2 constitutes a targetable vulnerability via deUFMylation-dependent activation of AKT oncogenic signaling.
26 Oct 2026· Cell reports· PUBMED
Publication
Transcutaneous auricular vagus nerve stimulation attenuates post-stroke dysphagia by modulating microglial polarization via the endothelial VWF/PI3K-Akt axis.
25 Oct 2026· Brain research· PUBMED
Publication
The PHLPP paradox revisited: from canonical AKT phosphatases to signaling pseudoenzymes in human disease.
25 Oct 2026· Biochemical pharmacology· PUBMED
Publication
Fufang Xianzhuli Ye attenuates airway inflammation and epithelial injury in experimental asthma: involvement of PI3K-Akt and PPAR-γ signaling and associated lipid metabolic changes.
24 Oct 2026· Journal of natural medicines· PUBMED
Publication
Recombinant spinach ribosome-inactivating protein induces cytotoxicity and alters gene expression associated with PTEN/AKT/mTOR signaling, apoptosis, and stemness in HT29 cells.
23 Oct 2026· European journal of pharmacology· PUBMED
Publication
Shikonin combined with curcumin synergistically induces apoptosis of glioma cells by inhibiting the PI3K/Akt/NF-κB signaling pathway.
23 Oct 2026· Oncology letters· PUBMED
Publication
Licorice flavonoids ameliorate type 2 diabetes mellitus via modulation of the AMPK/mTORC1/AKT signaling network.
22 Oct 2026· Journal of drug targeting· PUBMED
Publication
P2Y6 receptor activation promotes the migration, invasion and glycogen accumulation of colorectal cancer through AKT/mTOR signaling.
22 Oct 2026· Tissue & cell· PUBMED
Publication
Author Correction: β-catenin confers resistance to PI3K and AKT inhibitors and subverts FOXO3a to promote metastasis in colon cancer.
22 Oct 2026· Nature medicine· PUBMED
Publication
Yindan Xinnaotong Soft Capsule Ameliorates Parkinson's Disease and is Associated with Modulation of the AKT/MDM2/p53 Pathway: Network Pharmacology, Molecular Docking, and Experimental Validation.
22 Oct 2026· CNS & neurological disorders drug targets· PUBMED
Publication
RETRACTION: The Mechanism of the Yigutang-Mediated P13K/AKT/GSK-3β Signal Pathway to Regulate Osteogenic Differentiation of Bone Marrow Stromal Stem Cells to Treat Osteoporosis.
22 Oct 2026· Evidence-based complementary and alternative medicine : eCAM· PUBMED
Publication
WTAP/YTHDC1-mediated m6A modification of P4HA1 suppresses hepatic gluconeogenesis and ameliorates MASLD by activating AKT signaling.
22 Oct 2026· Cellular signalling· PUBMED