New trials, publications, preprints and grants on this target, month by month.
Trial
Postsurgical Pain and Opioid Use in Older Adults: Effects of Mild Cognitive Impairment
1 Jan 2027· NA · NOT_YET_RECRUITING· CTGOV
Trial
Predicting Pre-dementia
15 Nov 2026· NA · RECRUITING· CTGOV
Publication
Quantitative pathology and APOE genotype reveal dementia risk and progression in Lewy body disease.
4 Nov 2026· Brain : a journal of neurology· PUBMED
Publication
Engineering ApoE-Mimetic HDL-Like Nanoparticles for Glioblastoma-Targeted Theranostics.
4 Nov 2026· Small methods· PUBMED
Publication
ApoE is associated with retinal inflammation during the progression of retinitis pigmentosa.
3 Nov 2026· Experimental eye research· PUBMED
Trial
A Nutritional and Pharmacological Intervention for Body, Brain, and Longevity Effects (NIBBLE)
1 Nov 2026· PHASE1_PHASE2 · NOT_YET_RECRUITING· CTGOV
Publication
NSG Mice Lacking Apoe: An Immunodeficient Mouse Model of Atherosclerosis.
31 Oct 2026· FASEB journal : official publication of the Federation of American Societies for Experimental Biology· PUBMED
Trial
A Postmarketing Study of LEQEMBI in Participants With Alzheimer's Disease
30 Oct 2026· NA · NOT_YET_RECRUITING· CTGOV
Publication
APOE ε4 accelerates plasma p-tau217 trajectory: a Bayesian joint longitudinal analysis of ADNI.
23 Oct 2026· Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology· PUBMED
Publication
A phase III trial of ALZT-OP1 (cromolyn + ibuprofen) in early Alzheimer's disease: Primary results and exploratory analyses by APOE4 genotype.
23 Oct 2026· Journal of Alzheimer's disease : JAD· PUBMED
Publication
Exploring the role of depression in the association between APOE ε4 and cognitive function: Evidence from the Brain Health Registry.
19 Oct 2026· Journal of psychiatric research· PUBMED
Publication
Astrocyte-Associated ABCA1/APOE Responses Accompany Hippocampal Lipid Remodeling and Ectopic Neuronal Accumulation During Epileptogenesis.
18 Oct 2026· Advanced science (Weinheim, Baden-Wurttemberg, Germany)· PUBMED
Publication
Role of APOE ɛ4 and ɛ2 With Longitudinal Cognitive Decline Among Those With Exceptional Longevity: The LifeAfter90 Study.
16 Oct 2026· Neurology· PUBMED
Publication
APOE Beyond Alzheimer Disease: Cognitive Aging in the Oldest Old.
16 Oct 2026· Neurology· PUBMED
Publication
Smooth muscle cell mineralocorticoid receptor does not contribute to atherosclerosis in male or female ApoE-knockout mice.
15 Oct 2026· PloS one· PUBMED
Publication
Genome-wide CRISPR screen reveals that Wnt signaling regulates lipid accumulation in APOE4 oligodendrocytes.
15 Oct 2026· Cell stem cell· PUBMED
Publication
Cross-cohort transfer of clinical Alzheimer's EEG signatures to cognitively healthy APOE-ε4 and PICALM rs3851179 risk carriers using differentiable logic gate networks.
15 Oct 2026· Computers in biology and medicine· PUBMED
Publication
Docosahexaenoic acid remodels lipid composition of lipid rafts and mitochondrial function in ApoE4/4 mouse brain: a multi-omic investigation.
15 Oct 2026· Molecular biomedicine· PUBMED
Publication
Sex-divergent vulnerability to chronic peripheral LPS challenge in aged ApoE4 mice: Male systemic fragility versus female central neuroinflammation.
15 Oct 2026· Behavioural brain research· PUBMED
Publication
Lifestyle, APOE ε4, amyloid burden, and race/ethnicity differences in cognition, mood, and anxiety among cognitively unimpaired older adults.
14 Oct 2026· Alzheimer's & dementia (Amsterdam, Netherlands)· PUBMED
Publication
Brain DNA methylation, APOE genotype and Alzheimer's disease neuropathology in a large postmortem cohort.
12 Oct 2026· Nature aging· PUBMED
Preprint
Clinical utility of plasma APOE proteotyping for Alzheimer's disease risk and prognosis.
11 Oct 2026· medRxiv : the preprint server for health sciences· PUBMED
Publication
Accelerated hippocampal atrophy in APOE ε4 homozygotes and females: Longitudinal findings from the Tohoku Medical Megabank MRI study.
9 Oct 2026· Neuroradiology· PUBMED
Publication
Global and regional amyloid-β in explaining APOE-ε4 and sex associations with medial temporal tau: a neuropathology study.
9 Oct 2026· Acta neuropathologica· PUBMED
Publication
Remote Identification of APOE-ε4 Carrier Status in Cognitively Normal Adults via Speech Acoustics: Cross-Sectional Observational Study.
8 Oct 2026· JMIR formative research· PUBMED
Publication
Episodic memory retrieval with increasing task demand: associations with age, APOE4 genotype and Alzheimer's disease pathology.
7 Oct 2026· Brain communications· PUBMED
Publication
Exploratory Analysis of APOE ε4-Stratified Associations Between Plasma Alzheimer's Biomarkers and Retinal Imaging Metrics in Cognitively Normal Adults.
5 Oct 2026· Translational vision science & technology· PUBMED
Publication
Emerging therapeutic strategies to target APOE4 in Alzheimer's disease.
5 Oct 2026· The FEBS journal· PUBMED
Publication
Calpain-1 deficiency alleviates oxidative stress and hepatic injury in ApoE-deficient mice with MASH.
5 Oct 2026· Tissue & cell· PUBMED
Publication
Association of neighborhood deprivation with Alzheimer's disease pathology, brain structure, and cognition by race and ethnicity, sex, and APOE ε4 status.
1 Oct 2026· Alzheimer's & dementia : the journal of the Alzheimer's Association· PUBMED