New trials, publications, preprints and grants on this target, month by month.
Publication
Endothelial BACE1 impairs insulin signaling to drive cerebral small vessel disease and stroke.
16 Oct 2026· Science bulletin· PUBMED
Publication
Sulfamethoxazole Attenuates Aluminum-induced Cognitive Impairment: In silico Evidence for BACE1 Interaction and In vivo Behavioral Assessment.
8 Oct 2026· Current drug targets· PUBMED
Publication
Targeting the BACE1-GSK-3β Signaling Axis in Alzheimer's Disease: From Molecular Crosstalk to Nanotechnology-Based Translational Strategies.
21 Sept 2026· Molecular neurobiology· PUBMED
Publication
Machine Learning-Guided Discovery of Natural BACE1 Inhibitors with Enzymatic and Cellular Validation.
16 Sept 2026· ACS omega· PUBMED
Publication
Design, Synthesis, and Biological Activity of Isothiocyanate-Triazine Conjugates as AChE and BACE1 Inhibitors.
3 Sept 2026· Biomolecules· PUBMED
Publication
Age-dependent biphasic alterations and protein-activity decoupling of plasma BACE1 in major depressive disorder.
26 Aug 2026· Frontiers in psychiatry· PUBMED
Publication
Leveraging molecular dynamics to unravel the inhibition mechanism of potential β-secretase (BACE1) inhibitors.
26 Aug 2026· Physical chemistry chemical physics : PCCP· PUBMED
Publication
A self-powered photoelectrochemical sensor with ultra-low background based on ZnIn2S4@CdS photoanode and Bi2WO6 photocathode for BACE1 detection.
14 Aug 2026· Biosensors & bioelectronics· PUBMED
Publication
Integrated Virtual Screening and Molecular Electrostatic Surface Potential Descriptors for Predicting BACE1 Inhibitor Interactions in Alzheimer's Disease.
7 Aug 2026· ACS omega· PUBMED
Publication
ARG128-associated recognition of nobiletin by BACE1 revealed by triplicate molecular dynamics, MM-GBSA, and residue-level decomposition.
7 Aug 2026· Molecular diversity· PUBMED
Publication
Cannabis flower extracts as a multi-target agent in Alzheimer's disease: Inhibition of AChE, BChE, and BACE1 with cell-protective effects in a PC12 cell model.
31 Jul 2026· Journal of cannabis research· PUBMED
Publication
Development of a Novel AAV-Mediated microRNA Gene Therapy for Spatial Suppression of BACE1 to Improve Cognitive Function in Alzheimer's Disease Model Mice.
23 Jul 2026· Biomolecules· PUBMED
Publication
Robust multi-parameter classification-QSAR-based prioritization: Evaluating ranking stability under weight uncertainty for BACE1 inhibitor discovery.
17 Jul 2026· Computational biology and chemistry· PUBMED
Publication
Unveiling the structural insights and inhibitory potential of coumarin-1,2,3-triazole hybrids against BACE1: a promising approach for Alzheimer's disease therapy.
7 Jul 2026· Frontiers in chemistry· PUBMED
Publication
A 19F MRI/NIR-FL Nanoprobe for "Turn-On" Imaging of β-Secretase (BACE1) Activity in Alzheimer's Disease.
8 Jun 2026· Angewandte Chemie (International ed. in English)· PUBMED
Publication
FBXW7α regulates amyloid pathology by mediating ubiquitination and degradation of BACE1 in Alzheimer's disease.
20 May 2026· Cell death discovery· PUBMED
Publication
Retraction: Repurposing food molecules as a potential BACE1 inhibitor for Alzheimer's disease.
14 May 2026· Frontiers in aging neuroscience· PUBMED
Publication
WITHDRAWN: Molecular basis of BACE1 modulation revealed by machine learning, molecular simulations, and experimental validation.
6 May 2026· International journal of biological macromolecules· PUBMED
Publication
NeuroBACE-ML: A reliability-aware screening framework for high-throughput prioritization of potent BACE1 inhibitors.
17 Apr 2026· Journal of molecular graphics & modelling· PUBMED
Publication
Recent advances towards BACE1 drug discovery and therapeutics design.
9 Apr 2026· RSC medicinal chemistry· PUBMED
Publication
Intranasal Formaldehyde Exposure Induces RAGE-Mediated Alteration of the ADAM10/BACE1 Expression Balance and Amyloid Deposition.
30 Mar 2026· Biomedicines· PUBMED
Publication
BDNF alters β-cleavage of APP and subcellular distribution of BACE1.
23 Mar 2026· American journal of physiology. Cell physiology· PUBMED
Publication
In vitro, in vivo, and in silico profiling of optimized hydrazide-hydrazone indole congeners as multi-faceted AChE, BACE1, and MAO-B inhibitors for Alzheimer's disease therapy.
19 Mar 2026· Bioorganic chemistry· PUBMED
Publication
HDAC6 regulates BACE1 stability and NLRP3 inflammasome activation in Alzheimer's disease.
6 Mar 2026· Brain : a journal of neurology· PUBMED
Publication
Increase in BACE1 Phosphorylation in the Rat Hippocampus and Phytosphingosine in Plasma After Chronic Administration of Scopolamine.
27 Feb 2026· International journal of molecular sciences· PUBMED
Publication
In silico evaluation of bioactive compounds as potential inhibitors targeting HIF-1α/VEGFA/BACE1 pathway against Alzheimer's disease.
25 Feb 2026· Journal of complementary & integrative medicine· PUBMED
Publication
Identifying Potential BACE1 Inhibitors from the ChEMBL Database Using Machine Learning and Atomistic Simulation Approaches.
6 Feb 2026· ACS omega· PUBMED
Publication
Synaptic Vesicle Glycoprotein 2A Suppresses Amyloidogenesis Beyond Its Synaptic Role: A Novel Mechanism Disrupting BACE1 Binding and Altering APP Localization.
1 Feb 2026· Aging cell· PUBMED
Publication
Computational prioritization of multi-target inhibitors: explainable QSAR and docking-based discovery of dual AChE/BACE1 chemotypes.
28 Jan 2026· Journal of computer-aided molecular design· PUBMED
Publication
Discontinued BACE1 Inhibitors in Phase II/III Clinical Trials and AM-6494 (Preclinical) Towards Alzheimer's Disease Therapy: Repurposing Through Network Pharmacology and Molecular Docking Approach.
13 Jan 2026· Pharmaceuticals (Basel, Switzerland)· PUBMED