New trials, publications, preprints and grants on this target, month by month.
Trial
Prizloncabtagene Autoleucel (Prizlon-cel) for the Treatment of Relapsed or Refractory Large B-cell Lymphoma Post FDA Approved CAR T-cell Therapy
1 May 2027· PHASE2 · NOT_YET_RECRUITING· CTGOV
Trial
A Study of LP-118 In Combination With Ponatinib, Dexamethasone And Blinatumomab For Adults With Newly-Diagnosed, BCR::ABL1-Positive Acute Lymphoblastic Leukemia (ALL)
1 Dec 2026· PHASE1 · RECRUITING· CTGOV
Trial
Nemtabrutinib for Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Leukemia (SLL) Refractory to Covalent Bruton Tyrosine Kinase Inhibitor or Pirtobrutinib and Previously Treated With a BCL2 Inhibitor
11 Nov 2026· PHASE2 · NOT_YET_RECRUITING· CTGOV
Publication
Cytotoxic effects and modulation of BAX/BCL-2 gene expression induced by plant-derived cerium oxide nanoparticles in HepG2 cells.
31 Oct 2026· Cytotechnology· PUBMED
Publication
Assessment of BCL-2 expression in bone marrow by flow cytometry to aid in the diagnosis and differential diagnosis in patients with follicular lymphoma.
30 Oct 2026· Cytometry. Part B, Clinical cytometry· PUBMED
Publication
Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl-2 and Mcl-1 blockade in preclinical glioblastoma models.
24 Oct 2026· FEBS open bio· PUBMED
Publication
Gudan Wan attenuates metabolic dysfunction-associated steatohepatitis by modulating autophagy and the Bcl-2/Caspase-3/Caspase-8 apoptotic axis.
22 Oct 2026· Frontiers in cell and developmental biology· PUBMED
Publication
Immunohistochemical Expression of M30, BCL-2, BAX, and Ki-67 in Pancreatic Ductal Adenocarcinoma: Association with Clinicopathological Features.
21 Oct 2026· Diagnostics (Basel, Switzerland)· PUBMED
Publication
A Novel BCL2 Translocation and Concurrent Chromosome 13q14 Deletion in Chronic Lymphocytic Leukemia: A Case Report.
18 Oct 2026· EJHaem· PUBMED
Publication
Engineered solid lipid-polymer hybrid nanoparticles for trackable co-delivery of glycoalkaloids and Bcl-2/CD146-targeting of siRNAs: A topical formulation strategy for melanoma.
17 Oct 2026· Colloids and surfaces. B, Biointerfaces· PUBMED
Publication
Rational structure-guided identification of a Bcl-2-targeting peptide with antiproliferative effects on colorectal cancer cells.
14 Oct 2026· Journal of enzyme inhibition and medicinal chemistry· PUBMED
Trial
A Phase II Study of TT-01488 Tablets in Combination With Anti-CD20 Monoclonal Antibody Therapy in Patients With Mantle Cell Lymphoma
10 Oct 2026· PHASE2 · NOT_YET_RECRUITING· CTGOV
Publication
Retraction Note: Histone acetyltransferase PCAF accelerates apoptosis by repressing a GLI1/BCL2/BAX axis in hepatocellular carcinoma.
8 Oct 2026· Cell death & disease· PUBMED
Publication
Enhanced Antileukemic Efficacy of Venetoclax-Loaded PEG-PLGA Nanoparticles Against THP-1 Acute Monocytic Leukemia Cells via Suppression of BCL-2 and Pro-Survival Signaling Pathways.
6 Oct 2026· Biomedicines· PUBMED
Trial
Real-World Study of BCL-2 Inhibitor-Based Regimens in Chronic Lymphocytic Leukemia
1 Oct 2026· NA · RECRUITING· CTGOV
Publication
Correction: The proapoptotic BCL-2 family member BIM mediates motoneuron loss in a model of amyotrophic lateral sclerosis.
1 Oct 2026· Cell death and differentiation· PUBMED
Publication
Extranodal Organ Involvement in Chronic Lymphocytic Leukemia: Clinical Features and Outcomes With Bruton Tyrosine Kinase and BCL-2 Inhibitors.
1 Oct 2026· Cancer medicine· PUBMED
Publication
Immunohistochemical expression of E-cadherin and Bcl-2 in oral squamous cell carcinoma.
30 Sept 2026· Indian journal of cancer· PUBMED
Publication
Deciphering the clinical significance of Beclin-1 and Bcl-2 in urothelial carcinoma of bladder.
29 Sept 2026· Indian journal of urology : IJU : journal of the Urological Society of India· PUBMED
Publication
BushenQiangxin Formula Inhibits Inflammation and Apoptosis in Doxorubicin- Induced Heart Failure via the NF-κB/Bcl-2 Axis.
25 Sept 2026· Current drug metabolism· PUBMED
Publication
Combining the Telomerase Inhibitor Imetelstat with the BCL-2 Inhibitor Venetoclax Enhances Apoptosis and Improves Survival in Acute Myeloid Leukemia Cellular and Animal Models.
23 Sept 2026· Journal of clinical medicine· PUBMED
Publication
Integrative Systems Biology Prioritizes BCL2, ALK, and CDK4 as Therapeutic Candidates in Neuroblastoma through Multi-Centrality Network Analysis, Cross-Database Validation, Independent Docking Validation, and Confidence-Threshold Sensitivity Analysis.
21 Sept 2026· Computational biology and chemistry· PUBMED
Publication
RAS seals fate in AML besieged by FLT3 and BCL2 inhibitors.
17 Sept 2026· Blood· PUBMED
Publication
Dynamic genetic and nongenetic RAS-pathway activation drives resistance to FLT3 and BCL2 inhibitor therapy.
17 Sept 2026· Blood· PUBMED
Publication
GATA3-driven CDC20 activation facilitates tumor growth and metastasis through suppressing Bax/Bcl-2 ratio and boosting EMT process in neuroblastoma.
12 Sept 2026· The Journal of biological chemistry· PUBMED
Publication
Impact of BCL-2 rs2279115 and rs3943258 variants on protein expression and clinical outcome of urothelial bladder carcinoma.
7 Sept 2026· Molecular biology reports· PUBMED
Publication
Testicular aggressive B-cell lymphoma with plasmablastic morphology harboring concurrent IGH::MYC and IGH::BCL2 rearrangements.
7 Sept 2026· Journal of hematopathology· PUBMED
Publication
CRC cell cycle arrest and early apoptosis induction by mononuclear octahedral cobalt(III) Schiff base through the inhibition of CDK4/6 and BCL2.
5 Sept 2026· Medical oncology (Northwood, London, England)· PUBMED
Publication
Evaluation of Programmed Death Ligand-1 (PD-L1) and B-cell Lymphoma 2 (BCL2) protein expression using immunohistochemistry in colorectal carcinoma patients from Anbar Governorate.
4 Sept 2026· Journal of the Egyptian National Cancer Institute· PUBMED
Publication
BCL-2 inhibition at antiretroviral therapy initiation reduces the intact SIV reservoir in macaques.
3 Sept 2026· Nature microbiology· PUBMED