Target

C9orf72

Guanine nucleotide exchange factor C9orf72

Also: C9ORF72

4open trials
12trials in total
144publications
0researchers

Diseases

The last 24 months

New trials, publications, preprints and grants on this target, month by month.

TrialsPublicationsPreprintsGrants

Publication
A validated antibody toolbox for ALS research.
3 Nov 2026· eLife· PUBMED
Preprint
Structural basis for repeat-associated non-AUG translation initiation on C9orf72 mRNA.
28 Oct 2026· bioRxiv : the preprint server for biology· PUBMED
Publication
Mild cognitive impairment in presymptomatic amyotrophic lateral sclerosis.
25 Oct 2026· Journal of neurology· PUBMED
Publication
Beyond Monogenic Inheritance: Emerging Genetic Architecture of Amyotrophic Lateral Sclerosis.
21 Oct 2026· International journal of molecular sciences· PUBMED
Publication
Sigma-1 Receptor Mitigates Poly-GR-Associated Redox Dysregulation by Restoring NRF2/HO1 Signaling in C9orf72-Associated ALS.
11 Oct 2026· Neuromolecular medicine· PUBMED
Publication
Astrocytes regulate axonal mitochondrial transport deficits in C9ORF72 amyotrophic lateral sclerosis motor neurons.
7 Oct 2026· Nature neuroscience· PUBMED
Preprint
Somatic instability of the C9orf72 repeat expansion in blood differs between patients with amyotrophic lateral sclerosis or frontotemporal dementia.
7 Oct 2026· medRxiv : the preprint server for health sciences· PUBMED
Publication
PAICS mediates DNA damage and cerebellar neuronal loss in C9orf72 amyotrophic lateral sclerosis.
5 Oct 2026· Brain : a journal of neurology· PUBMED
Publication
Association between C9orf72 G4C2 repeat length and idiopathic Parkinson's disease in a Turkish cohort.
1 Oct 2026· Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology· PUBMED
Publication
Plasma Proteomic Signatures Predict Incident Amyotrophic Lateral Sclerosis: A Prospective Study Stratified by C9orf72 Expansion.
1 Oct 2026· Journal of cachexia, sarcopenia and muscle· PUBMED
Publication
Integrative synaptosome multi-omics reveals disrupted synapse organization and localized cryptic transcripts in C9ORF72-frontotemporal dementia.
25 Sept 2026· Acta neuropathologica· PUBMED
Publication
AUG-Dependent Translation of Antisense Repeat Transcripts Contributes to Dipeptide Repeat Protein Production in C9ORF72 Expansion Carriers.
19 Sept 2026· Cells· PUBMED
Publication
Tracking Socio-emotional Brain Changes in Premanifest C9orf72 Repeat Expansion Carriers: A Structural and Functional 2-Year Longitudinal Magnetic Resonance Imaging Study.
7 Sept 2026· Annals of neurology· PUBMED
Publication
Altered neuronal start codon stringency favors cap-independent repeat-associated non-AUG translation.
7 Sept 2026· Nucleic acids research· PUBMED
Publication
Proteomic and Functional Signatures of Phenoconversion in Presymptomatic Amyotrophic Lateral Sclerosis.
3 Sept 2026· Journal of clinical neuromuscular disease· PUBMED
Publication
Multivariate Survival Analysis of a Comprehensive Clinical Trial of Rapamycin in Amyotrophic Lateral Sclerosis Explores Prognostic Factors and Survival Patterns in C9orf72 Carriers.
1 Sept 2026· European journal of neurology· PUBMED
Publication
Longitudinal functional network connectivity changes across the clinical stages of C9orf72 hexanucleotide repeat expansion carriers.
1 Sept 2026· Alzheimer's & dementia : the journal of the Alzheimer's Association· PUBMED
Publication
Genetic ALS-Progressive Sleep Defects Precede the Onset of Clinical Disease.
1 Sept 2026· European journal of neurology· PUBMED
Publication
The spectrum of C9orf72 repeat lengths in Portuguese frontotemporal dementia and amyotrophic lateral sclerosis patients: from pathogenic expansions to intermediate alleles.
31 Aug 2026· Frontiers in neuroscience· PUBMED
Publication
Cognitive and behavioral manifestations of the C9orf72 mutation in Amyotrophic Lateral Sclerosis: an age, education, and gender-matched cohort study.
28 Aug 2026· Amyotrophic lateral sclerosis & frontotemporal degeneration· PUBMED
Publication
Theory of mind impairment related to C9orf72 repeat expansion in amyotrophic lateral sclerosis: a case-control study.
24 Aug 2026· Amyotrophic lateral sclerosis & frontotemporal degeneration· PUBMED
Publication
Generation of two iPSC lines from ALS patients harboring C9orf72 hexanucleotide repeat expansions.
22 Aug 2026· Stem cell research· PUBMED
Publication
A replicated astrocyte long non-coding RNA signature of Alzheimer's disease is inverted in amyotrophic lateral sclerosis.
21 Aug 2026· Brain research· PUBMED
Publication
Functional Activity of TDP-43: A Direct Biomarker for ALS.
17 Aug 2026· Biosensors· PUBMED
Preprint
Oral administration of dibenzoylmethane (DBM) prevents cognitive decline in a C9ORF72-mediated FTD mouse model.
10 Aug 2026· bioRxiv : the preprint server for biology· PUBMED
Publication
Wild-type C9orf72 drives proteasomal dysfunction and mutant aggregates via a Stat1-Isg15 axis in Huntington's disease.
6 Aug 2026· Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics· PUBMED
Publication
C9orf72-associated and sporadic FTD patient iPSC-microglia show differences in phagocytosis and gene expression.
6 Aug 2026· Stem cell reports· PUBMED
Publication
Glial cell toxicity in a Drosophila C9orf72 neurodegeneration model.
5 Aug 2026· PLoS genetics· PUBMED
Publication
Genetic profile of motor neuron disease in a multiregional Brazilian cohort: an 18-year real-world experience in 1,911 patients.
5 Aug 2026· Frontiers in neurology· PUBMED
Publication
RAN Translation-Coupled Decay of the C9orf72 GGGGCC Repeat Transcript by the RNA Exosome Suppresses Dipeptide Repeat Production.
4 Aug 2026· International journal of molecular sciences· PUBMED

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