Target

CCR5

C-C chemokine receptor type 5

3open trials
10trials in total
130publications
0researchers

Diseases

The last 24 months

New trials, publications, preprints and grants on this target, month by month.

TrialsPublicationsPreprintsGrants

Trial
CCR5 Targeting Leronlimab in Combination With Hepatic Arterial Infusion Floxuridine and Systemic Therapy for the Treatment of Colorectal Cancer Liver Metastases, CHAMP Trial
6 May 2027· PHASE1 · NOT_YET_RECRUITING· CTGOV
Preprint
End-To-End, Fully Automated Manufacturing of Hematopoietic Stem and Progenitor Cell Therapy Via CCR5 -Targeted Integration.
30 Oct 2026· bioRxiv : the preprint server for biology· PUBMED
Publication
A Multivariate Statistics Approach to Analyze the Transition from CCR5 to Dual and CXCR4 Tropism and to Predict the Coreceptor Usage of HIV-1.
16 Oct 2026· Current HIV research· PUBMED
Publication
A Curated Phenotype-Linked HIV-1 Sequence Dataset for Machine Learning Approaches to Tropism Prediction, Disease Progression and Proviral Reservoir Studies.
14 Oct 2026· Viruses· PUBMED
Publication
Evaluation of Anti-HIV-1 HSPC-Based Gene Therapy with Negative Selection Marker in Pigtail Macaques.
13 Oct 2026· Viruses· PUBMED
Publication
Systematic Review and Meta-Analysis of Genome-Wide CRISPR-Cas Screens to Identify Host Factors Involved in HIV-1 Infection.
13 Oct 2026· Viruses· PUBMED
Publication
CCR5 protects against permanent brain ischemia by suppressing neuronal ferroptosis through AMPK/ACC signaling.
30 Sept 2026· Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics· PUBMED
Publication
Mailuoning oral liquid alleviates permanent ischemic stroke by targeting CCR5 to modulate microglial polarization and PI3K/AKT/mTOR axis.
30 Sept 2026· International immunopharmacology· PUBMED
Publication
PD-L1 antibody-induced cardiac dysfunction is regulated by CCR5-positive macrophages.
19 Sept 2026· European journal of pharmacology· PUBMED
Publication
CCR5Δ32 Polymorphism and Inflammatory Bowel Disease: A Case-Control and Genotype-Phenotype Study in a Polish Population.
17 Sept 2026· International journal of molecular sciences· PUBMED
Publication
Expression of Toll-like Receptors and Chemokine Receptors in the Early and Advanced Stages of HIV Infection Aggravated by Mycobacterium tuberculosis.
14 Sept 2026· International journal of molecular sciences· PUBMED
Publication
HIV cure: from early therapies to cutting-edge strategies.
14 Sept 2026· Journal of neurovirology· PUBMED
Publication
Investigating the Link Between Specific Signaling Molecules (CCL5, CCR5, CXCR4, BMPR2) and Cardiac Health Indicators in Rheumatoid Arthritis Individuals: A Cross-Sectional Study.
11 Sept 2026· Health science reports· PUBMED
Publication
CCR5 as a Therapeutic Target in HIV Disease: From CRISPR/Cas9 Gene Editing to Maraviroc-Mediated Inhibition.
3 Sept 2026· Viruses· PUBMED
Publication
CCR2/CCR5 Signaling Defines a Pathogenic Interstitial Macrophage Subset That Drives Severe Asthma.
1 Sept 2026· Clinical and translational allergy· PUBMED
Publication
L-Threonic Acid Inhibits Pathological Retinal Neovascularization by Modulation of CCL3-CCR5 Signaling Pathway.
1 Sept 2026· Investigative ophthalmology & visual science· PUBMED
Publication
Increased CCR5 expression in lymphoma cells and M2 macrophages is associated with poor prognosis in primary intestinal diffuse large B-cell lymphoma.
1 Sept 2026· The journal of pathology. Clinical research· PUBMED
Publication
Emerging CCR5-Based Therapeutic Potential of JAK/STAT Inhibitors and CCR5Δ32 Hematopoietic Stem Cell Transplantation.
27 Aug 2026· Viruses· PUBMED
Publication
Triple-Target CRISPR Strategy to Block HIV Entry and Replication in Permissive Cells.
23 Aug 2026· Human gene therapy· PUBMED
Publication
Combination therapy with broadly neutralizing antibodies, antiretroviral therapy and CCR5 blockade limits viral reservoir seeding in infant macaque model of HIV.
10 Aug 2026· Nature microbiology· PUBMED
Publication
Unveiling CCL5: the master regulator of breast cancer progression and immune evasion.
6 Aug 2026· Breast cancer research : BCR· PUBMED
Publication
Development of an investigational medicinal stem cell gene therapy product to attempt curing human immunodeficiency virus infection.
4 Aug 2026· Scientific reports· PUBMED
Publication
CKLF1 upregulation exacerbates secondary brain injury after intracerebral hemorrhage by promoting neuronal ferroptosis and oxidative stress.
3 Aug 2026· Free radical biology & medicine· PUBMED
Publication
CCR5 drives glucose metabolic reprogramming to control microglial synaptic pruning via histone lactylation in a mouse model of depression.
29 Jul 2026· Cell reports· PUBMED
Publication
Host genetics influences HIV reservoir persistence, treatment outcomes and CCR5 expression in patients on long-term antiretroviral therapy in Ghana.
22 Jul 2026· Frontiers in immunology· PUBMED
Publication
Integrated virtual screening and molecular dynamics reveal novel Maraviroc analogues as optimized CCR5 entry inhibitors for HIV-1.
20 Jul 2026· Journal of molecular graphics & modelling· PUBMED
Publication
Zhimu-Huangbo herb pair ameliorates diabetic cognitive impairment by modulating the CCL3-CCR5 axis-dependent interaction between neurons and CD8+ T cells.
19 Jul 2026· Phytomedicine : international journal of phytotherapy and phytopharmacology· PUBMED
Publication
Beyond CCR5 and HLA: rare genetic variants in HIV acquisition and disease progression.
10 Jul 2026· Frontiers in genetics· PUBMED
Publication
Pharmacophore-based identification and molecular docking of CCR5 inhibitors: insights from dynamic simulations.
10 Jul 2026· Journal of receptor and signal transduction research· PUBMED
Publication
Development of a virus particle fusion assay to study and target virus entry.
8 Jul 2026· Virology· PUBMED

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