Target

CFTR

Cystic fibrosis transmembrane conductance regulator

30open trials
62trials in total
302publications
0researchers

Diseases

The last 24 months

New trials, publications, preprints and grants on this target, month by month.

TrialsPublicationsPreprintsGrants

Trial
Pharmacokinetics of CFTR Modulators in Pregnant Individuals and in Postpartum Breastfeeding Mothers
1 Jan 2027· NA · NOT_YET_RECRUITING· CTGOV
Publication
Continued burden of nontuberculous mycobacteria in the screened subpopulations of people with cystic fibrosis receiving CFTR modulator therapy.
5 Nov 2026· Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society· PUBMED
Publication
The PDE4 inhibitor tanimilast (CHF6001) activates CFTR function in native and in F508del-expressing airway epithelial cells.
5 Nov 2026· European journal of pharmacology· PUBMED
Publication
Offering prenatal CFTR modulators to prevent cystic fibrosis-related organ damage in utero.
3 Nov 2026· American journal of obstetrics & gynecology MFM· PUBMED
Trial
Novel Point-of-care Sweat Chloride Testing Device for Monitoring CFTR Function
1 Nov 2026· NA · NOT_YET_RECRUITING· CTGOV
Publication
Acute kidney injury after aminoglycoside exposure in two cystic fibrosis patients receiving triple CFTR modulator therapy.
30 Oct 2026· Journal of nephrology· PUBMED
Publication
Evaluation of potential relationship between CFTR modulators, CFTR and neuropsychiatric symptoms in CF.
27 Oct 2026· Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society· PUBMED
Publication
Oligonucleotide correction of a rare CFTR intron 12 splicing variant from a cystic fibrosis patient.
26 Oct 2026· ERJ open research· PUBMED
Publication
Cutaneous adverse reactions following initiation of vanzacaftor/tezacaftor/deutivacaftor in CFTR-modulator-naïve subjects: a case series.
26 Oct 2026· Respiratory medicine· PUBMED
Trial
A Precision Medicine Approach to Assess Protein Function Loss and the Potential for CFTR Function Restoration in Cystic Fibrosis and Related Disorders
22 Oct 2026· NA · RECRUITING· CTGOV
Publication
A phase 2a study with SPL84: A novel RNA-targeted approach to restore CFTR function in people with CF carrying the 3849+10 kb C→T mutation.
15 Oct 2026· The European respiratory journal· PUBMED
Publication
Defective Inflammation Resolution in Cystic Fibrosis: Cellular Mechanisms and Emerging Pro-resolving Therapies in the CFTR Modulator Era.
11 Oct 2026· Current topics in microbiology and immunology· PUBMED
Publication
CFTR I556V Variant Exacerbates Cigarette Smoke-Induced Airway Inflammation in COPD by Promoting NLRP3 Inflammasome Activation.
11 Oct 2026· International journal of chronic obstructive pulmonary disease· PUBMED
Trial
Vascular Health and Function in Cystic Fibrosis
10 Oct 2026· NA · NOT_YET_RECRUITING· CTGOV
Publication
Perspectives on inhaled medicines in the CFTR modulator era: A national survey of adults with cystic fibrosis.
10 Oct 2026· Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society· PUBMED
Publication
Neutrophil Elastase Regulates CFTR Function in Airway Disease.
9 Oct 2026· American journal of physiology. Lung cellular and molecular physiology· PUBMED
Publication
CFTR Functional Rescue and Heterogeneous Clinical Outcomes Following Elexacaftor/Tezacaftor/Ivacaftor Therapy in People with Cystic Fibrosis Carrying the W1282R Variant.
7 Oct 2026· International journal of molecular sciences· PUBMED
Publication
Vanzacaftor/tezacaftor/deutivacaftor partially restores CFTR function of the L467F;F508del complex allele in primary nasal epithelial cells.
3 Oct 2026· Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society· PUBMED
Publication
Assessment of CFTR Dysfunction and Responsiveness to CFTR Modulators in COPD Bronchial Air-Liquid Interface Cultures.
1 Oct 2026· International journal of molecular sciences· PUBMED
Publication
Targeted insertion of partial CFTR cDNA replicates native CFTR expression with restored channel function in CF airway epithelium.
1 Oct 2026· Molecular therapy. Nucleic acids· PUBMED
Publication
Metabolic alterations in cystic fibrosis lymphocyte memory accompany restoration of CFTR function.
1 Oct 2026· American journal of respiratory cell and molecular biology· PUBMED
Publication
Residual-Function and Splicing CFTR Variants Characterize False-Negative IRT Newborn Screening: A Ten-Year Single-Center Cohort From Türkiye.
1 Oct 2026· Pediatric pulmonology· PUBMED
Publication
Late-Diagnosed Cystic Fibrosis with Co-Occurring CFTR 3849+10kbC>T and 5T Variants: A Case Report.
30 Sept 2026· Journal of clinical medicine· PUBMED
Publication
CFTR variant-associated hereditary pancreatitis complicated by diabetes mellitus: a case report and literature review.
29 Sept 2026· Frontiers in endocrinology· PUBMED
Publication
Comparison of Prime Editing and CRISPR-Cas Mediated HDR in Correcting CFTR-F508del Mutation in Patient iPSC-Derived Airway Basal Cells.
26 Sept 2026· International journal of molecular sciences· PUBMED
Publication
Functional and Compositional Shifts in Lung and Gut Microbiota after One Year of Treatment with Highly Effective CFTR Modulators in Cystic Fibrosis.
25 Sept 2026· Archivos de bronconeumologia· PUBMED
Publication
Elexacaftor/tezacaftor/ivacaftor improves CFTR function to near-normal levels in children with cystic fibrosis.
24 Sept 2026· The European respiratory journal· PUBMED
Publication
Maternal and fetal outcomes associated with CFTR modulator use during pregnancy: a scoping review.
23 Sept 2026· European respiratory review : an official journal of the European Respiratory Society· PUBMED
Publication
CFTR Modulation by Plantago asiatica Flavonoids: A Potential Antisecretory Mechanism Against Diarrhoea.
22 Sept 2026· Membranes· PUBMED
Publication
Changes in Inhaled Antibiotic-Associated Lung Function Outcomes in the CFTR Modulator Era.
21 Sept 2026· Chest· PUBMED

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