New trials, publications, preprints and grants on this target, month by month.
Trial
Pacritinib, a Kinase Inhibitor of CSF1R, IRAK1, JAK2, and FLT3, in Adults and Pediatric Participants 12 Years of Age or Older With Myelodysplastic Syndromes or Myelodysplastic/Myeloproliferative Neoplasms
11 Nov 2026· PHASE1_PHASE2 · RECRUITING· CTGOV
Publication
Motor neuron disease and parkinsonism in a patient with a pathogenic CSF1R variant.
26 Oct 2026· Revue neurologique· PUBMED
Publication
Marked intrafamilial phenotypic heterogeneity associated with the CSF1R c.2539G>A pathogenic variant in a Japanese family.
14 Oct 2026· Journal of neural transmission (Vienna, Austria : 1996)· PUBMED
Publication
Inhibition of adipocyte-macrophage interaction via CSF1-CSF1R by curcumin.
8 Oct 2026· Journal of physiology and biochemistry· PUBMED
Publication
Targeting IGF2BP3-driven CSF1/CSF1R signaling disrupts the positive feedback loop between tumor cells and macrophages and inhibits HCC progression.
16 Sept 2026· Life sciences· PUBMED
Publication
Discovery of oxazole-capped 4-phenoxypiperidine CSF1R type II inhibitors with potent in vivo anti-rheumatoid arthritis activity.
8 Sept 2026· Bioorganic chemistry· PUBMED
Publication
WTAP Transcriptional Suppression by KLF9 Drives Osteoclastogenesis via M6A-Mediated Regulation of CSF1R Signaling in Estrogen-Deficient Osteoporosis.
30 Aug 2026· Advanced science (Weinheim, Baden-Wurttemberg, Germany)· PUBMED
Publication
A CSF-1R Ig4-5 Domain-Targeting Antibody for the Treatment of Idiopathic Pulmonary Fibrosis.
11 Aug 2026· Antibodies (Basel, Switzerland)· PUBMED
Publication
CSF1R Inhibition with Chemotherapy Relieves Systemic Immune Suppression in Patients with Metastatic Triple-Negative Breast Cancer and Boosts Anti-PD-1 Efficacy in Transgenic Mammary Tumors.
17 Jul 2026· Clinical cancer research : an official journal of the American Association for Cancer Research· PUBMED
Publication
Dual inhibition of CSF-1R and IDO modulates the fibrotic and immunosuppressive tumor microenvironment in pancreatic ductal adenocarcinoma.
15 Jul 2026· Frontiers in immunology· PUBMED
Publication
CSF1R inhibition exacerbates gamma oscillation disruption and induces network hyperexcitability in APP/PS1 mice.
14 Jul 2026· Brain : a journal of neurology· PUBMED
Publication
CSF1R inhibition following antibody mediated demyelination has limited impact on remyelination.
9 Jul 2026· Acta neuropathologica communications· PUBMED
Publication
Regional mapping of CSF1R-positive microglia in neurodegenerative diseases and progressive MS, with exploratory presynaptic marker analyses.
4 Jul 2026· Journal of neuroinflammation· PUBMED
Publication
Highlighting the CSF1R mutational spectrum: c.2549C>T variant in late-onset leukoencephalopathy mimicking multiple sclerosis.
24 Jun 2026· Neurologia i neurochirurgia polska· PUBMED
Publication
H3K18 lactylation promotes allergic airway inflammation in asthma via a CSF1/CSF1R/MAPK autocrine axis.
23 Jun 2026· Respiratory research· PUBMED
Publication
Genetic screening for CSF1R variants in patients with dementia, parkinsonism, and multiple sclerosis.
11 Jun 2026· Neurologia i neurochirurgia polska· PUBMED
Publication
Analysis of the Oncogenic Role of Colony-Stimulating Factor 1 Receptor (CSF1R) in Pancreatic Adenocarcinoma.
9 Jun 2026· Anti-cancer agents in medicinal chemistry· PUBMED
Publication
CSF-1R inhibition and lenalidomide synergize to promote myeloma control after autologous stem cell transplantation.
4 Jun 2026· Blood· PUBMED
Trial
ASTRAEA: ReinvigorAting ReSponse To ImmunotheRApy in MEtAstatic TNBC With Combination Myeloid Inhibition and Radiation
1 Jun 2026· PHASE2 · NOT_YET_RECRUITING· CTGOV
Publication
CSF1R-dependent CD169-positive macrophages locally constrain melanoma growth in the skin.
21 May 2026· The Journal of experimental medicine· PUBMED
Publication
Single-photon emission computed tomography 123I-ioflupane imaging in CSF1R mutation carriers.
16 Apr 2026· Neurologia i neurochirurgia polska· PUBMED
Publication
Discovery of novel CSF1R inhibitor for triple-negative breast cancer (TNBC) treatment through TAMs reprogramming.
16 Apr 2026· Biochemical pharmacology· PUBMED
Publication
Novel Insights into the Pathogenic Role of CSF1R in Endometriosis.
14 Apr 2026· Reproductive sciences (Thousand Oaks, Calif.)· PUBMED
Preprint
Serial Thermal Ablation Induces Abscopal Antitumor Immunity and Reveals Targetable CSF1R-Dependent Resistance in Pancreatic Cancer.
8 Apr 2026· bioRxiv : the preprint server for biology· PUBMED
Publication
Immune cell clustering identifies a CD163⁺/CSF1R⁺ macrophage and neutrophil-enriched phenotype with distinct biological signatures and poor prognosis in angiosarcoma.
23 Mar 2026· Oncoimmunology· PUBMED
Publication
Safety and immunologic impact of neoadjuvant/adjuvant GVAX, cyclophosphamide, pembrolizumab, and anti-CSF1R agent IMC-CS4 in pancreatic adenocarcinoma.
9 Mar 2026· Frontiers in immunology· PUBMED
Publication
The impact of CSF1R inhibitor-mediated microglial depletion in rodent models of Alzheimer's and Parkinson's disease: a systematic review and meta-analysis.
25 Feb 2026· Frontiers in aging neuroscience· PUBMED
Publication
Colorectal cancer-derived osteopontin rewires macrophages into a pro-metastatic M2 state via the PI3K/AKT/CSF1-CSF1R axis.
5 Feb 2026· Cell death discovery· PUBMED
Publication
CSF1R mutations in an Italian population of early-onset dementia: a case series.
4 Feb 2026· Journal of neurology· PUBMED
Publication
Systemic CSF1R Targeting Depletes Pathogenic MPS Bubs and Ameliorates Psoriasis via PPARα-mediated Resolution.
30 Jan 2026· Theranostics· PUBMED