Target

CTNNB1

Catenin beta-1

Also: β-catenin

9open trials
11trials in total
732publications
0researchers

Diseases

The last 24 months

New trials, publications, preprints and grants on this target, month by month.

TrialsPublicationsPreprintsGrants

Publication
Correction: MEF2A transcriptionally upregulates the expression of ZEB2 and CTNNB1 in colorectal cancer to promote tumor progression.
1 Dec 2026· Oncogene· PUBMED
Publication
Temporally evolving neuronal remodeling via the CTNNB1-NRG3-ERBB4 axis drives therapy resistance in glioblastoma.
6 Nov 2026· Molecular biomedicine· PUBMED
Publication
Targeting tankyrase scaffolding in the β-catenin destruction complex by PROTAC overcomes the limitation of catalytic inhibitors in colorectal cancer.
4 Nov 2026· eLife· PUBMED
Publication
Integrated multi-omics and experimental evidence implicate DVL3-associated Wnt/β-catenin signaling in PFHxS-related colorectal cancer progression.
2 Nov 2026· Ecotoxicology and environmental safety· PUBMED
Trial
EBV-Tscm Cytotoxic T Cells (CTLs) for EBV- Driven Lymphomas/ Diseases
1 Nov 2026· PHASE1_PHASE2 · NOT_YET_RECRUITING· CTGOV
Publication
Wnt/β-catenin signaling dysregulation in Alzheimer's disease and therapeutic opportunities.
28 Oct 2026· Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie· PUBMED
Publication
Oncogenic Role of PLOD3 in Melanoma Progression via Wnt/β-catenin Signaling and Tumor Microenvironment Reprogramming.
27 Oct 2026· Journal of visualized experiments : JoVE· PUBMED
Publication
Se@SiO2@mSiO2 nanoparticle inhibits cellular oxidative stress and Wnt/β-catenin pathway by inhibiting AGGF1 expression in the treatment of prostate cancer.
23 Oct 2026· Journal of translational internal medicine· PUBMED
Publication
Author Correction: β-catenin confers resistance to PI3K and AKT inhibitors and subverts FOXO3a to promote metastasis in colon cancer.
22 Oct 2026· Nature medicine· PUBMED
Publication
Plant cytokinin ortho-topolin riboside suppresses the proliferation of multiple myeloma cells by promoting β-catenin degradation.
21 Oct 2026· BMB reports· PUBMED
Publication
Proto-oncoprotein PAK4 is associated with nuclear accumulation of pro-oncogenic melanotransferrin and β-catenin in melanoma cells.
21 Oct 2026· Biochimica et biophysica acta. Molecular basis of disease· PUBMED
Publication
Non-coding RNA networks remodeling metastatic signaling in the lung cancer microenvironment: a focus on TGF-β signaling and its crosstalk with Wnt/β-catenin, HIF, Notch, integrin, and CXCL12/CXCR4 pathways.
19 Oct 2026· Cancer treatment and research communications· PUBMED
Publication
Lipocalin-2 inhibition regulates pain-like facial expression associated with neuroinflammation involving the NF-κB/β-catenin pathway during orthodontic tooth movement in a type 2 diabetic model.
18 Oct 2026· Archives of oral biology· PUBMED
Publication
PBRM1 Deficiency in Microglia Leads to Excessive Neurogenesis and Autism-Like Behaviors via the CCL5-CCR1/5-β-catenin Signaling Axis.
18 Oct 2026· Advanced science (Weinheim, Baden-Wurttemberg, Germany)· PUBMED
Publication
Whole-Exome and Whole-Genome Sequencing Identifies Driver CTNNB1 Mutations in Ossifying Renal Tumor of Infancy.
16 Oct 2026· The American journal of surgical pathology· PUBMED
Publication
BIRC3 facilitates osteogenic differentiation of bone marrow mesenchymal stem cells via NGFR/β-catenin signalling axis.
16 Oct 2026· Bone & joint research· PUBMED
Publication
A Novel De Novo Heterozygous Missense Variant in CTNNB1 (c.2215A>C, p.Met739Leu) Underlying Neurodevelopmental Disorder With Spastic Diplegia and Visual Defects (NEDSDV): A Case Report.
16 Oct 2026· Clinical case reports· PUBMED
Publication
Luteolin inhibits prostate cancer stem cells through disrupting the lactate/H3K18la/β-catenin/LDHA feedback loop.
15 Oct 2026· Molecular and cellular biochemistry· PUBMED
Publication
S100A4 Promotes the Proliferation and Invasion of Gastric Cancer Cells and Regulates the Reprogramming of Fatty Acid Metabolism via the Wnt/β-catenin Signaling Pathway.
15 Oct 2026· Frontiers in bioscience (Landmark edition)· PUBMED
Publication
ARID2 Loss Reprograms the Kynurenine-AhR Pathway to Restore Antitumor Immunity in CTNNB1-Mutant Hepatocellular Carcinoma.
14 Oct 2026· Cancer research· PUBMED
Publication
Piperlongumine alleviates colitis by promoting β-catenin proteasomal degradation to inhibit NLRP3 inflammasome activation and pyroptosis.
13 Oct 2026· European journal of pharmacology· PUBMED
Publication
Boosting the nuclear Wnt/β-catenin feedback loop for the specific elimination of colorectal cancer.
12 Oct 2026· Gut· PUBMED
Publication
Wnt/β-catenin and D2 receptor signaling crosstalk in disease mechanisms.
12 Oct 2026· Open life sciences· PUBMED
Publication
CT radiomics and topology-based intratumoral heterogeneity for preoperative prediction of nuclear β-catenin expression in hepatocellular carcinoma.
10 Oct 2026· Abdominal radiology (New York)· PUBMED
Publication
LEF1 expression in melanocytic tumors cannot accurately predict CTNNB1 mutational status acting as a potential pitfall in bi-phenotypic lesions.
10 Oct 2026· Virchows Archiv : an international journal of pathology· PUBMED
Publication
Neuroprotective effects of lithium and caffeic acid co-loaded liposomes in diabetes-induced Alzheimer's disease: association with GSK-3β and β-catenin.
10 Oct 2026· Nanomedicine (London, England)· PUBMED
Publication
Berberine inhibits gastric cancer progression by targeting canonical Wnt/β-catenin signaling in AGS cells.
9 Oct 2026· Naunyn-Schmiedeberg's archives of pharmacology· PUBMED
Publication
Erratum for the Research Article "A novel β-catenin/BCL9 complex inhibitor blocks oncogenic Wnt signaling and disrupts cholesterol homeostasis in colorectal cancer".
9 Oct 2026· Science advances· PUBMED
Publication
Prochlorperazine inhibits the proliferation of hepatocellular carcinoma cells by promoting phosphorylation of β-catenin.
7 Oct 2026· Anti-cancer drugs· PUBMED
Publication
Quercetin upregulates TLE4 to block the Wnt/β-catenin signaling pathway and inhibit cell migration and invasion of cervical cancer cells.
7 Oct 2026· Frontiers in pharmacology· PUBMED

Who works on it

Researchers who published on this target. Leave out your own co-author circle to find people you do not know yet.

No published researcher profile on this target yet.

We look for a fixed list of target names in titles, keywords, intervention names and MeSH terms. A mention does not prove that the work is aimed at that target.

Report an error