New trials, publications, preprints and grants on this target, month by month.
Publication
Clinical Study Protocol for PENTILULA: A Phase 1/2 Study Assessing [177Lu]Lu-Pentixather for Relapsed or Refractory CXCR4-Positive Acute Leukemia.
5 Nov 2026· Journal of nuclear medicine : official publication, Society of Nuclear Medicine· PUBMED
Publication
Network Medicine Identifies a FOSL1/SNAI1-CCND1/CXCR4 Network Associated with N-Methyl-N'-nitro-N-nitrosoguanidine-Related Gastric Precancerous Lesions and Modulated by Apigenin.
2 Nov 2026· Chemico-biological interactions· PUBMED
Publication
Autoimmune-shared immune states converge in a CXCL12-CXCR4 fibroblast-immune niche in chronic antibody-mediated rejection.
2 Nov 2026· Signal transduction and targeted therapy· PUBMED
Publication
Clinical and immunological correlates of CXCR4 coreceptor use in people with HIV-1 receiving antiretroviral therapy in the Netherlands: a multicentre cohort study.
29 Oct 2026· The Lancet. Microbe· PUBMED
Publication
CXCR4-dependent migratory differences between peripheral Tregs and Tcons preserve GVL while limiting GVHD after HSCT.
27 Oct 2026· Blood advances· PUBMED
Publication
Lipopolysaccharide increases cell migration and invasion via NF-κB-mediated upregulation of CXCR4 in gallbladder cancer.
26 Oct 2026· Medical oncology (Northwood, London, England)· PUBMED
Trial
U69-CART-Cells For R/R T-ALL
25 Oct 2026· PHASE1 · RECRUITING· CTGOV
Publication
Multi-omics analysis of high-grade serous ovarian cancers reveals heterogeneity and distinct immunological patterns based upon clinico-genomic status.
22 Oct 2026· PLoS genetics· PUBMED
Publication
FATP5 loss in hepatocellular carcinoma cells orchestrates tumor-promoting microenvironment by inducing passive long-chain fatty acid accumulation within tumor-associated endothelial cells.
22 Oct 2026· Oncogene· PUBMED
Trial
Base-Edited Hematopoietic Stem/Progenitor Cell Gene Therapy for Treatment of CXCR4-WHIM
21 Oct 2026· PHASE1_PHASE2 · ENROLLING_BY_INVITATION· CTGOV
Publication
Acetaldehyde Dehydrogenase 2 Remodels the Tumor Immune Microenvironment via CXCR4-CXCL12 Signaling in Head and Neck Squamous Cell Carcinoma.
21 Oct 2026· The Journal of biological chemistry· PUBMED
Publication
Non-coding RNA networks remodeling metastatic signaling in the lung cancer microenvironment: a focus on TGF-β signaling and its crosstalk with Wnt/β-catenin, HIF, Notch, integrin, and CXCL12/CXCR4 pathways.
19 Oct 2026· Cancer treatment and research communications· PUBMED
Publication
Dose-dependent CXCR4 inhibition in ovarian cancer cellular models reveals a paradoxical response characterized by subtype-specific oncogenic suppression and stress-induced adaptive rebound.
16 Oct 2026· Molecular biology reports· PUBMED
Publication
A Multivariate Statistics Approach to Analyze the Transition from CCR5 to Dual and CXCR4 Tropism and to Predict the Coreceptor Usage of HIV-1.
16 Oct 2026· Current HIV research· PUBMED
Publication
FOXC2 regulates macrophage polarization and osteosarcoma progression via the CXCL12/CXCR4 signaling axis.
15 Oct 2026· The Journal of pathology· PUBMED
Publication
A Curated Phenotype-Linked HIV-1 Sequence Dataset for Machine Learning Approaches to Tropism Prediction, Disease Progression and Proviral Reservoir Studies.
14 Oct 2026· Viruses· PUBMED
Publication
Computational identification of natural CXCR4-binding candidates relevant to endometriosis and ovarian cancer progression.
7 Oct 2026· PloS one· PUBMED
Publication
A Dual-Action CXCR4-Targeted Peptide-Drug Conjugate Engineered to Enhance Antitumor Efficacy and Mitigate Myelosuppression in Pancreatic Cancer.
5 Oct 2026· Molecular pharmaceutics· PUBMED
Trial
Evaluation of the Value of [68Ga]Ga-PENTIXAFOR PET-CT in Patients With Metastatic Small Cell Lung Cancer (SCLC)
30 Sept 2026· EARLY_PHASE1 · NOT_YET_RECRUITING· CTGOV
Publication
Gene expression analysis after BTK and PI3Kδ inhibitor treatment in chronic lymphocytic leukemia identifies cell-surface CXCR4 as a synergistic target for combinatorial therapy.
25 Sept 2026· HemaSphere· PUBMED
Publication
Neoadjuvant chemotherapy interferes with tertiary lymphoid structure formation in Epstein-Barr virus-associated gastric cancer.
23 Sept 2026· Nature communications· PUBMED
Publication
Engineered polymeric systems suppress breast cancer metastasis by manipulating the clustering states of cell surface C-X-C chemokine receptor 4.
20 Sept 2026· Journal of controlled release : official journal of the Controlled Release Society· PUBMED
Publication
GOLPH3-mediated sialylation of CXCR4 drives malignant progression and M2 macrophage polarization in colorectal cancer.
16 Sept 2026· Apoptosis : an international journal on programmed cell death· PUBMED
Publication
C-X-C Motif Chemokine Receptor 4 (CXCR4)-Targeted Biologically Guided Proton Spatially Fractionated Radiotherapy for Bulky Limited-Stage Small Cell Lung Cancer.
12 Sept 2026· Precision radiation oncology· PUBMED
Publication
Investigating the Link Between Specific Signaling Molecules (CCL5, CCR5, CXCR4, BMPR2) and Cardiac Health Indicators in Rheumatoid Arthritis Individuals: A Cross-Sectional Study.
11 Sept 2026· Health science reports· PUBMED
Publication
CXCR4-directed liposomal co-delivery of cytarabine and AMD3100 for redox-associated chemosensitization in acute myeloid leukemia.
10 Sept 2026· Colloids and surfaces. B, Biointerfaces· PUBMED
Publication
CXCR4+ circulating tumor cells (CTCs) accumulate in subcutaneous, immune suppressive, CXCL12-loaded-hydrogel.
4 Sept 2026· Materials today. Bio· PUBMED
Publication
CXCR4-centred signalling network rewiring distinguishes primary and metastatic prostate cancer: A systems-level digital twin framework.
3 Sept 2026· European journal of cell biology· PUBMED
Publication
Spatial dissection of antibody-drug conjugate/radiopharmaceutical therapy targets defines heterogeneous expression landscapes and therapeutic implications in rhabdoid tumors.
1 Sept 2026· Neuro-oncology· PUBMED
Publication
Design, Preclinical Evaluation, and Clinical Translation of [68Ga]Ga/[177Lu]Lu-JH120061, a Novel Radiopharmaceutical Targeting CXCR4.
1 Sept 2026· Clinical cancer research : an official journal of the American Association for Cancer Research· PUBMED