Target

ERK

Extracellular signal-regulated kinase

Also: ERK1/2, ERK1, ERK2

3open trials
15trials in total
708publications
0researchers

Diseases

The last 24 months

New trials, publications, preprints and grants on this target, month by month.

TrialsPublicationsPreprintsGrants

Publication
Protective effects of quercetin in experimental ulcerative colitis: Potential involvement of ERK-MMP signaling.
1 Jan 2027· Pakistan journal of pharmaceutical sciences· PUBMED
Publication
ERK1/2 Inhibitor Ulixertinib in Pancancer Patients with BRAF Fusions or Non-V600E/K Mutations: Results from the NCI-MATCH ECOG-ACRIN Trial (EAY131) Subprotocol Z1L.
2 Nov 2026· Clinical cancer research : an official journal of the American Association for Cancer Research· PUBMED
Publication
Intranasal Delivery of an Antioxidant Nanoassembly for Cerebral Ischemia-Reperfusion Injury via Drd2/β-arrestin2/ERK Signaling.
28 Oct 2026· ACS applied materials & interfaces· PUBMED
Publication
Mechanisms of cetuximab resistance in head and neck squamous cell Carcinoma: Focus on the EGFR-ERK pathway.
27 Oct 2026· Biochemical pharmacology· PUBMED
Publication
TFAP2A-driven PTK6 promotes endometrial cancer progression through activation of the MEK/ERK signaling pathway.
26 Oct 2026· International immunopharmacology· PUBMED
Publication
Glycosylated steroidal saponins suppress HNSCC progression by targeting the RAS-ERK pathway.
26 Oct 2026· Biochemical pharmacology· PUBMED
Publication
Immunohistochemical analysis of phospho-ERK1/2 in odontogenic cysts.
23 Oct 2026· Journal of applied oral science : revista FOB· PUBMED
Publication
SSPH I, a Novel Anti-Cancer Saponin, Inhibits Autophagy and Induces Apoptosis via ROS Accumulation and ERK1/2 Signaling Pathway in Hepatocellular Carcinoma Cells [Retraction].
22 Oct 2026· OncoTargets and therapy· PUBMED
Publication
Inhibition of Bone Morphogenetic Protein 2 Suppresses the Stemness Maintenance of Cancer Stem Cells in Hepatocellular Carcinoma via the MAPK/ERK Pathway [Retraction].
21 Oct 2026· Cancer management and research· PUBMED
Publication
Editor's Note: ERK Regulates HIF1α-Mediated Platinum Resistance by Directly Targeting PHD2 in Ovarian Cancer.
15 Oct 2026· Clinical cancer research : an official journal of the American Association for Cancer Research· PUBMED
Publication
FAM43B mediates BMAL1-driven regulation of ERK signaling to promote cervical cancer progression.
15 Oct 2026· Journal of molecular histology· PUBMED
Publication
Hyperthermia exacerbates methamphetamine cardiotoxicity by promoting neutrophil-dominant inflammation and Map3k6-associated p38/ERK signaling.
14 Oct 2026· Toxicology and applied pharmacology· PUBMED
Publication
Sex-dependent cross-resilience to social defeat and learned helplessness: The role of BDNF-ERK signaling and norepinephrine.
14 Oct 2026· Neurobiology of stress· PUBMED
Publication
Combined rituximab and magnesium acetyl taurate therapy attenuates neurodegeneration via ERK/c-JNK/P38MAPK signaling modulation in methylmercury-induced amyotrophic lateral sclerosis-like neurotoxicity.
13 Oct 2026· Naunyn-Schmiedeberg's archives of pharmacology· PUBMED
Publication
Inhibition of the MEK-ERK signaling pathway reverses acquired osimertinib resistance in NSCLC attributed to AXL overexpression.
13 Oct 2026· Life sciences· PUBMED
Publication
Intracellular COMP drives ovarian cancer progression through AKT/ERK signaling with concomitant pathway-dependent transgelin upregulation.
9 Oct 2026· Acta biochimica et biophysica Sinica· PUBMED
Publication
Galectin-3 accelerates the progression of cerebral infarction by regulating the ERK/ROS/BRD4-mediated P2X7R/MerTK balance in microglia.
8 Oct 2026· Biochemical and biophysical research communications· PUBMED
Publication
Dietary Zeaxanthin Attenuates Cigarette Smoke-Induced COPD by Suppressing ERK-Driven Apoptosis.
8 Oct 2026· The Journal of nutritional biochemistry· PUBMED
Publication
ZBED6 deficiency drives pathological cardiac hypertrophy through MEOX1-ERK1/2-dependent autophagy dysfunction.
8 Oct 2026· PLoS genetics· PUBMED
Publication
RSPO1-LGR4 axis drives cervical cancer progression via activation of the EGFR/Src/ERK/AKT signaling pathway.
7 Oct 2026· Neoplasia (New York, N.Y.)· PUBMED
Publication
Tomatidine hydrochloride suppresses intrahepatic cholangiocarcinoma progression by modulating CPA4 and inhibiting the MEK/ERK signaling pathway.
4 Oct 2026· Tissue & cell· PUBMED
Publication
Investigating the mechanism of Xiongfu formula and its active ingredient Z-Ligustilide alleviates chronic migraine by modulating the MAPK/ERK/CREB pathway and microglia-mediated neuroinflammation.
2 Oct 2026· Journal of ethnopharmacology· PUBMED
Publication
Author Correction: Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling.
1 Oct 2026· Nature cell biology· PUBMED
Publication
Erratum: Additive effect of Ruta graveolens bioactive phytoconstituents and cisplatin through PKC/MEK/ERK pathway in glioblastoma.
1 Oct 2026· Molecular therapy. Oncology· PUBMED
Publication
A nuclear ERK-ATF5 axis coordinates mitochondrial metabolism and thermogenic gene expression in brown adipocytes.
1 Oct 2026· The Journal of endocrinology· PUBMED
Publication
Interleukin-35 Ameliorates Obesity-Associated Impairment of Endothelium-Dependent Vasodilation via the STAT3-MAPK/ERK-eNOS Signaling Axis.
1 Oct 2026· Immunity, inflammation and disease· PUBMED
Publication
Lipocalin 13 Mitigates Metabolic Dysfunction-Associated Steatotic Liver Disease Through Inhibiting the ADRB2/ERK Signalling Pathway.
1 Oct 2026· Liver international : official journal of the International Association for the Study of the Liver· PUBMED
Publication
Triphenyl Phosphate Exposure Is Associated With BRG1-Related Cellular and Metabolic Readouts and EREG-EGFR/ERK Signalling in Glioma Cells.
1 Oct 2026· The international journal of medical robotics + computer assisted surgery : MRCAS· PUBMED
Publication
Mechanism of astragaloside-loaded lactosyl chitosan nanoparticles inhibiting MAPK/ERK pathway and preventing angiogenesis and colon cancer development through miR-200.
1 Oct 2026· Pakistan journal of pharmaceutical sciences· PUBMED
Publication
Quercetin Attenuates Cisplatin-Induced Nephrotoxicity While Enhancing Antitumor Efficacy in Gastric Cancer via Cell Type-Specific Modulation of the ERK1/2 Pathway.
1 Oct 2026· Journal of biochemical and molecular toxicology· PUBMED

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