Target

FAK

Focal adhesion kinase 1

Also: PTK2

3open trials
10trials in total
145publications
0researchers

Diseases

The last 24 months

New trials, publications, preprints and grants on this target, month by month.

TrialsPublicationsPreprintsGrants

Publication
A Retinal Matrix Stiffening Model Reveals FAK-Dependent Mechanotransduction in Pericytes Underlies Vascular Destabilization.
2 Nov 2026· Advanced materials (Deerfield Beach, Fla.)· PUBMED
Publication
Modulation of the FAK-Src Signalling Axis by Oncoviruses: Molecular Mechanisms, Functional Consequences, and Therapeutic Opportunities.
1 Nov 2026· Reviews in medical virology· PUBMED
Publication
Correction: Strategic selection of MDM2 inhibitors enhances the efficacy of FAK inhibition in mesothelioma based on TP53 genotype.
26 Oct 2026· PloS one· PUBMED
Publication
Zyxin protects against hypertensive nephropathy by restraining FAK/Skp2-CDK8/YAP signaling in tubular epithelial cells.
17 Oct 2026· Inflammation research : official journal of the European Histamine Research Society ... [et al.]· PUBMED
Publication
Irisin promotes lipid clearance through the CD81-integrin-FAK axis in steatotic hepatocytes.
17 Oct 2026· Journal of physiology and biochemistry· PUBMED
Publication
A marine-derived sesterterpenoid inhibits migration and invasion of triple-negative breast cancer cells by suppressing the FAK signaling pathway.
15 Oct 2026· Frontiers in cell and developmental biology· PUBMED
Publication
PINK1 promotes the progression of lung squamous cell carcinoma through the FAK/AKT/RhoA/vinculin pathway.
2 Oct 2026· Oncology reports· PUBMED
Publication
FAK inhibitor and RAF/MEK clamp avutometinib enhance KRAS G12C inhibitor efficacy in preclinical models of non-small cell lung cancer.
30 Sept 2026· Science translational medicine· PUBMED
Publication
Progress with FAK inhibitors in the patent literature (2020-present).
20 Sept 2026· Expert opinion on therapeutic patents· PUBMED
Publication
Tumor FAK supports fibrillar collagen expression in ovarian cancer ascites.
17 Sept 2026· Matrix biology : journal of the International Society for Matrix Biology· PUBMED
Publication
β-Myrcene alleviates atopic dermatitis-like inflammation and is associated with ECM-FAK/Src-YAP signaling during epidermal barrier repair.
16 Sept 2026· European journal of pharmacology· PUBMED
Publication
Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation.
14 Sept 2026· Molecular oncology· PUBMED
Publication
Narciclasine reduces proliferation and migration of neuroblastoma cells and decreases FAK/PI3K pathway activation.
29 Aug 2026· Medical oncology (Northwood, London, England)· PUBMED
Preprint
Loss of endothelial cell FAK represses cisplatin-induced vascular senescence in distal niches to reduce lung metastatic burden.
25 Aug 2026· Research square· PUBMED
Publication
Neutrophil Extracellular Trap-Derived DNA Activates the ITGB1/FAK Pathway to Promote Lung Adenocarcinoma Metastasis.
24 Aug 2026· Cancer research· PUBMED
Publication
Acid-activated Fe-doped layered double hydroxides coupling FAK blockade and chemodynamic therapy for triple-negative breast cancer.
20 Aug 2026· Biomaterials advances· PUBMED
Publication
ONC201 enhances the radiosensitivity of small-cell lung cancer via inhibition of the FAK signaling pathway.
14 Aug 2026· iScience· PUBMED
Publication
2-Ethylhexyl diphenyl phosphate exposure is associated with poorer overall survival in advanced high-grade serous ovarian cancer: Integrated epidemiological and experimental evidence implicating the ITGB1-FAK-AKT axis.
11 Aug 2026· Ecotoxicology and environmental safety· PUBMED
Publication
Combined FAK and MEK inhibition suppresses chromosome 8 gain malignant peripheral nerve sheath tumors.
11 Aug 2026· The Journal of clinical investigation· PUBMED
Publication
Editor's Note: FAK and IGF-IR interact to provide survival signals in human pancreatic adenocarcinoma cells.
5 Aug 2026· Carcinogenesis· PUBMED
Publication
Scutellarin alleviates obesity-induced renal fibrosis by regulating ITGA9 to suppress FAK/PI3K/AKT signaling.
3 Aug 2026· Phytomedicine : international journal of phytotherapy and phytopharmacology· PUBMED
Publication
RETRACTION: Fibronectin Promotes Migration and Invasion of Ovarian Cancer Cells through Up-Regulation of FAK-PI3K/Akt Pathway.
1 Aug 2026· Cell biology international· PUBMED
Publication
Novel androgen receptor N-terminal mutation drives gastric cancer metastasis via YWHAZ-mediated FAK pathway activation.
30 Jul 2026· Journal of translational medicine· PUBMED
Publication
Cuproplasia-associated LOXL2 cooperates with Helicobacter pylori infection to promote gastric cancer progression via the FAK/Src signaling axis.
24 Jul 2026· Journal of gastrointestinal oncology· PUBMED
Publication
Laminin γ2-ITGβ1-PD-L1 axis mediates gastric cancer cell heterogeneity in response to GCMSCs via FAK/YAP pathway.
23 Jul 2026· Cellular signalling· PUBMED
Publication
Syntaphilin Regulates Epithelial-Mesenchymal Transition and Metastasis in Gastric Cancer via the FAK/NF-κB/MMP-9 Signaling Pathway.
23 Jul 2026· International journal of molecular sciences· PUBMED
Publication
N6-methyladenosine-mediated upregulation of PAICS promotes lung-adenocarcinoma metastasis via the integrin-FAK signaling.
23 Jul 2026· Oncogene· PUBMED
Publication
WLJP-025p, a pectic polysaccharide from Lonicera japonica Thunb., suppresses proliferation and cellular respiration in IHH-4 thyroid cancer cells through a Gal-3-associated FAK/SRC signaling pathway.
22 Jul 2026· International journal of biological macromolecules· PUBMED
Publication
Scaffold hopping-directed design and discovery of N1-substituted aminopyrimidine-indole derivatives as FAK inhibitors with anti-pancreatic cancer activity.
17 Jul 2026· Bioorganic & medicinal chemistry· PUBMED
Preprint
Induced ERBB response and standing FAK dependency nominate separable KRAS-combination hypotheses in pancreatic cancer.
10 Jul 2026· bioRxiv : the preprint server for biology· PUBMED

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