Target

GLP-1

Glucagon-like peptide 1

Also: GLP-1RAs, GLP-1RA, GLP-1R, GLP1R, GLP1

244open trials
409trials in total
1829publications
0researchers

Diseases

Obesity284 trials
Type 2 diabetes115 trials
Type 1 diabetes27 trials
Chronic kidney disease11 trials
Fatty liver disease (MASLD/MASH)11 trials
Heart failure9 trials
Atrial fibrillation8 trials
Coronary artery disease6 trials
Endometrial cancer5 trials
HIV5 trials
Psoriasis5 trials
High blood pressure4 trials
Stroke4 trials
Cystic fibrosis3 trials
Multiple sclerosis3 trials
Psoriatic arthritis3 trials
Alzheimer disease2 trials
Diabetic eye disease2 trials
Pancreatic cancer2 trials
Prostate cancer2 trials

The last 24 months

New trials, publications, preprints and grants on this target, month by month.

TrialsPublicationsPreprintsGrants

Trial
Postpartum Semaglutide to Reduce Cardiometabolic Risk After Gestational Diabetes Mellitus
1 Sept 2027· PHASE2_PHASE3 · NOT_YET_RECRUITING· CTGOV
Trial
GLP-1 RA for Stage 1 Type 1 Diabetes
1 Sept 2027· PHASE2 · NOT_YET_RECRUITING· CTGOV
Trial
Brain and Obesity Longitudinal Development: Neurobiological Mechanisms of Semaglutide Treatment of Adolescent Obesity
1 Mar 2027· NA · NOT_YET_RECRUITING· CTGOV
Trial
Semaglutide for Weight Management During Hormone Therapy for Early Breast Cancer
1 Mar 2027· PHASE2 · NOT_YET_RECRUITING· CTGOV
Trial
Semaglutide for Low Back Pain
1 Feb 2027· PHASE2 · NOT_YET_RECRUITING· CTGOV
Trial
SHIELD-T1D: Shingrix and GLP-1 Agonist for Beta-Cell Preservation in Recent-Onset Type 1 Diabetes.
1 Jan 2027· PHASE2 · NOT_YET_RECRUITING· CTGOV
Trial
Efficacy of Tirzepatide for Weight Management in Patients With Suboptimal Weight Loss After Bariatric Surgery: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
1 Jan 2027· PHASE3 · NOT_YET_RECRUITING· CTGOV
Trial
Supplementation of Gut-brain Axis (GLP-1)-Activating Carbohydrates for Increasing Satiety in Adolescents With Obesity
1 Jan 2027· PHASE2 · NOT_YET_RECRUITING· CTGOV
Trial
SHAPE-ENDO: Pilot Randomized Trial of Multimodal Pre-Surgical Optimization Versus Standard Surgery in Patients With Obesity and Early-Stage Endometrial Cancer
1 Jan 2027· PHASE4 · NOT_YET_RECRUITING· CTGOV
Trial
Endoscopic Band Ligation for Type 2 Diabetes Mellitus (ENDOBAND-DM)
1 Jan 2027· NA · NOT_YET_RECRUITING· CTGOV
Trial
GLP-1/GIP Receptor Agonists in Obesity-Related HFpEF: The GLIDE-HF Registry
1 Jan 2027· NA · NOT_YET_RECRUITING· CTGOV
Publication
Oral small-molecule GLP-1 receptor agonist for type 2 diabetes and obesity.
20 Dec 2026· Lancet (London, England)· PUBMED
Trial
IGOB131 As A GLP-1 Modulator For Metabolic Disorders In Adults With Obesity
1 Dec 2026· PHASE2 · NOT_YET_RECRUITING· CTGOV
Trial
HMB Plus Vitamin D to Preserve Muscle in Older Adults Starting Semaglutide
1 Dec 2026· PHASE2 · NOT_YET_RECRUITING· CTGOV
Trial
Comparing Different Medication Regimens to Maintaining Weight Loss Among Adults With Obesity Using GLP-1s
1 Dec 2026· PHASE4 · NOT_YET_RECRUITING· CTGOV
Trial
UBT251 Injection Phase Ⅲ Study (OSA-NPAP)
1 Dec 2026· PHASE3 · NOT_YET_RECRUITING· CTGOV
Trial
Tirzepatide for the Treatment of Concurrent Type 1 Diabetes and Overweight or Obesity
1 Dec 2026· PHASE2 · NOT_YET_RECRUITING· CTGOV
Trial
Efficacy And Safety of Olatorepatide in Adults With Overweight or Obesity Without Diabetes
18 Nov 2026· PHASE3 · NOT_YET_RECRUITING· CTGOV
Trial
GLP-1 Plus Lifestyle for Overall Wellness: Find Your Way Forward
15 Nov 2026· PHASE4 · NOT_YET_RECRUITING· CTGOV
Trial
Comparing the Extent to Which Maridebart Cafraglutide is Made Available in the Body of Participants Living With Overweight or Obesity After Switching From Glucagon-like Peptide-1 Receptor Agonists (GLP-1RA)
13 Nov 2026· PHASE1 · RECRUITING· CTGOV
Publication
A practical framework for using GLP-1 RAs, SGLT2i, and MRAs with contemporary immunosuppression in kidney transplant recipients.
6 Nov 2026· Current opinion in nephrology and hypertension· PUBMED
Publication
NSAID initiation and risk for gastrointestinal bleeding in patients receiving GLP-1 receptor agonists: A retrospective cohort study.
5 Nov 2026· American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists· PUBMED
Publication
GLP-1 therapies and cancer risk.
5 Nov 2026· Science (New York, N.Y.)· PUBMED
Publication
The Influence of GLP-1 Receptor Agonists on the Outcomes and Tolerability of Colorectal Cancer Therapies.
5 Nov 2026· Current oncology reports· PUBMED
Publication
Direct cardiac or systemic? Reexamining the cardiovascular mechanisms of SGLT2 inhibitors and GLP-1 receptor agonists.
5 Nov 2026· Journal of basic and clinical physiology and pharmacology· PUBMED
Publication
GLP-1 and GIP receptor agonism does not directly drive skeletal muscle atrophy or impair myogenesis in primary human myotubes.
4 Nov 2026· GeroScience· PUBMED
Publication
Incidence of Barrett's Esophagus Among Adults With Obesity Treated with GLP-1 Receptor Agonists.
4 Nov 2026· The American journal of the medical sciences· PUBMED
Publication
Beyond Weight Loss: A Scoping Review and Thematic Analysis of GLP-1 Receptor Agonists Across the Neurosurgical Landscape.
3 Nov 2026· World neurosurgery· PUBMED
Publication
The Future Burden of Type 2 Diabetes and the Role of Glycaemic Control and GLP1-RAs.
3 Nov 2026· Mayo Clinic proceedings· PUBMED
Publication
In T2D, combined SGLT2i + GLP-1 RA vs. either alone does not reduce MACE or renal outcomes.
3 Nov 2026· Annals of internal medicine· PUBMED

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