GPC3

Diseases

• Liver and biliary tract cancer48 trials
• Lung cancer9 trials
• Childhood cancers8 trials
• Sarcoma8 trials
• Kidney cancer5 trials
• Pancreatic cancer4 trials
• Gastric and esophageal cancer3 trials
• Ovarian cancer3 trials
• Colorectal cancer2 trials
• Glioblastoma2 trials
• Endometrial cancer1 trial
• Mesothelioma1 trial
• Prostate cancer1 trial
• Triple-negative breast cancer1 trial

The last 24 months

New trials, publications, preprints and grants on this target, month by month.

TrialsPublicationsPreprintsGrants

• Trial

  Study Evaluating the Efficacy and Safety of BGB-B2033 in Participants With Advanced Hepatocellular Carcinoma

  30 Nov 2026· PHASE2 · NOT_YET_RECRUITING· CTGOV

• Trial

  Autologous CAR T Cells Targeting GPC3 (RPCAR01) for the Treatment of Advanced or Metastatic GPC3 Expressing Hepatocellular Carcinoma

  15 Nov 2026· PHASE1 · SUSPENDED· CTGOV

• Publication

  A multidimensional integrated diagnostic strategy using needle sheath flushing solution: combining PGM-based GPC3 protein detection and gene methylation analysis for improved liver cancer diagnosis.

  22 Oct 2026· Analytical methods : advancing methods and applications· PUBMED

• Publication

  Negative Correlation Between ADC Values and GPC3 Expression in Hepatocellular Carcinoma: A Quantitative Diffusion-Weighted Imaging Study.

  16 Oct 2026· Journal of hepatocellular carcinoma· PUBMED

• Publication

  Metabolic Rewiring of GPC3-Targeted CAR T Cells Expressing IL-15 and HER2-Targeted CAR T Cells via the ADA1-CD26 Axis Promotes Tumor Infiltration and Limits Systemic Toxicities.

  6 Oct 2026· Biomedicines· PUBMED

• Publication

  Phase I Trial of GPC3-Targeted TCR Fusion Construct, CT0180, in Patients with Advanced Hepatocellular Carcinoma.

  1 Oct 2026· Clinical cancer research : an official journal of the American Association for Cancer Research· PUBMED

• Publication

  Oncolytic virus-mediated GPC3 delivery overcomes antigen heterogeneity in hepatocellular carcinoma and enhances GPC3-directed immunotherapy.

  18 Sept 2026· Frontiers in immunology· PUBMED

• Publication

  Armouring GPC3 CAR T cells for hepatocellular carcinoma: how much is enough and what comes next?

  17 Sept 2026· Nature reviews. Clinical oncology· PUBMED

• Publication

  MRI-based radiomics for noninvasive prediction of GPC3 expression in hepatocellular carcinoma: a systematic review and meta-analysis.

  11 Sept 2026· Frontiers in oncology· PUBMED

• Publication

  Preclinical Evaluation of [68Ga]Ga-CS03 as a Novel GPC3-Targeted Probe for Imaging GPC3 in Hepatocellular Carcinoma Models.

  7 Sept 2026· Molecular pharmaceutics· PUBMED

• Trial

  GPC3 CAR T Cells With IL-15 and IL-21 for Recurrent ATRT and CNS Rhabdoid Tumors (RADIANT)

  1 Sept 2026· PHASE1 · NOT_YET_RECRUITING· CTGOV

• Trial

  GPC3-Targeted PET Imaging of 18F-X12 in Hepatocellular Carcinoma

  25 Aug 2026· NA · RECRUITING· CTGOV

• Publication

  Explainable machine learning-based multiphase contrast-enhanced CT radiomics for noninvasively predicting GPC3 expression in hepatocellular carcinoma: a bicentric study.

  15 Aug 2026· American journal of translational research· PUBMED

• Publication

  CSTF2-mediated 3'UTR shortening drives oncogenic activation of GPC3 in hepatocellular carcinoma.

  10 Aug 2026· Oncogene· PUBMED

• Publication

  CPNE1 promotes stemness and confers resistance to GPC3 CAR-T cell therapy in hepatocellular carcinoma via the STAT3-TGF-β signaling pathway.

  31 Jul 2026· Journal for immunotherapy of cancer· PUBMED

• Publication

  Molecular analysis of genes MICA, GPC3, PNPLA3, and TM6SF2 polymorphisms in patients of hepatocellular carcinoma.

  24 Jul 2026· Nucleosides, nucleotides & nucleic acids· PUBMED

• Preprint

  Heparan Sulfate Controls Nanoscale Assembly of GPC3-Wnt Receptor Complexes.

  22 Jul 2026· bioRxiv : the preprint server for biology· PUBMED

• Publication

  Single- and dual-target CAR-T cells targeting HBsAg and GPC3 to balance safety and antitumor efficacy in HBV-positive hepatocellular carcinoma.

  21 Jul 2026· iScience· PUBMED

• Publication

  GPC3-specific dnTGFβRII-armoured CAR T cells for hepatocellular carcinoma.

  15 Jul 2026· Nature· PUBMED

• Publication

  Advances in electrochemical biosensor applications for liver cancer diagnosis: Focusing on AFP and GPC3.

  15 Jul 2026· Analytical biochemistry· PUBMED

• Publication

  Comparative in vitro evaluation of fourth-generation anti-GPC3 CAR T-cells in hepatocellular carcinoma.

  6 Jul 2026· Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie· PUBMED

• Publication

  GPC3 chimeric antigen receptor (CAR)-NK cells combined with Enoblituzumab enhance the anti-tumor efficacy against hepatocellular carcinoma.

  25 Jun 2026· Biochemical and biophysical research communications· PUBMED

• Trial

  68Ga-NYM207 PET/CT Imaging in Hepatocellular Carcinoma

  11 Jun 2026· PHASE1_PHASE2 · RECRUITING· CTGOV

• Publication

  A cost-performance index for nano-optical biosensor evaluation: Systematic evaluation of europium-salicylate luminescent platforms for GPC3-targeted early HCC diagnosis.

  9 Jun 2026· Talanta· PUBMED

• Publication

  Development and Evaluation of an Albumin-Binding GPC3-Targeting Peptide for PET Imaging of Hepatocellular Carcinoma.

  8 Jun 2026· Molecular pharmaceutics· PUBMED

• Publication

  Local delivery of GPC3-CAR T cells in a thermosensitive hydrogel enhances antitumor efficacy in hepatocellular carcinoma.

  6 Jun 2026· International immunopharmacology· PUBMED

• Publication

  A clinical and contrast-enhanced CT-based model for preoperative prediction of CK19- and GPC3-positive dual-phenotype hepatocellular carcinoma.

  22 May 2026· Abdominal radiology (New York)· PUBMED

• Publication

  USP22 inhibition potentiates GPC3 chimeric antigen receptor macrophages efficacy in hepatocellular carcinoma by downregulating tumor CD24 expression.

  18 May 2026· Cancer letters· PUBMED

• Publication

  Pathomic biomarkers derived from whole-slide histopathology predict hepatocellular carcinoma progression and enable GPC3-linked tumour microenvironment stratification in a preclinical experimental oncology model.

  14 May 2026· Pathology, research and practice· PUBMED

• Publication

  Dual-adjuvanted GPC3 mRNA vaccine delivered by lipid nanoparticles for hepatocellular carcinoma immunotherapy.

  9 May 2026· Journal of controlled release : official journal of the Controlled Release Society· PUBMED

Who works on it

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