Target

GPX4

Glutathione peroxidase 4

0open trials
0trials in total
381publications
0researchers

The last 24 months

New trials, publications, preprints and grants on this target, month by month.

TrialsPublicationsPreprintsGrants

Publication
Rubioncolin C promotes ferroptosis by down-regulating Nrf2/HO-1/GPX4 signaling, restricting colorectal cancer progression and tumor immune escape.
5 Nov 2026· International immunopharmacology· PUBMED
Publication
The Histone Lactylation of KREMEN2 Inhibits Ferroptosis Through the JAK2/STAT3/GPX4 Axis and Promotes the Progression of Mantle Cell Lymphoma.
1 Nov 2026· Hematological oncology· PUBMED
Publication
Tuoli Xiaodu San Alleviates Ferroptosis in Ulcerative Colitis via Suppression of the DUOX2/GPX4 Axis.
29 Oct 2026· Journal of inflammation research· PUBMED
Publication
PROTAC-Loaded Nanoparticles Induce a "ROS Storm" through Targeted Degradation of GPX4 in Combination with a Mild Photothermal/Fenton-like Reaction for the Treatment of Triple-Negative Breast Cancer.
28 Oct 2026· ACS applied materials & interfaces· PUBMED
Publication
Withaferin A induces apoptosis and ferroptosis in gastric cancer cells via ROS-mediated mitochondrial damage and the Keap1/Nrf2/HO-1/GPX4 axis.
28 Oct 2026· Biochemical pharmacology· PUBMED
Publication
USP25 promotes ferroptosis in diabetic retinopathy by deubiquitinating p53 and suppressing the GPX4/SLC7A11 axis.
27 Oct 2026· Journal of diabetes investigation· PUBMED
Publication
A copper-based RNAi nanocomplex unleashes immunogenic ferroptosis by reversing metabolic adaptation and suppressing extracellular GPX4.
22 Oct 2026· Materials today. Bio· PUBMED
Publication
AFF3 regulates ferroptosis and malignant progression in bladder cancer cells via the NRF2/GPX4 signaling axis.
22 Oct 2026· European journal of histochemistry : EJH· PUBMED
Publication
Curcumin analogue FLLL32 induces ferroptosis by targeting the STAT3-GPX4/SLC40A1 axis in colorectal cancer.
20 Oct 2026· Molecular biomedicine· PUBMED
Publication
Ferroptosis-Related GPX4 and CD71 and Immune Checkpoint PD-L1 in Cutaneous Melanoma: Associations with Clinicopathologic Features and Survival Outcomes.
19 Oct 2026· International journal of molecular sciences· PUBMED
Publication
Needle-knife attenuates excessive autophagy and ferroptosis in post-stroke spastic hemiplegia: Association with SDC1/NRF2/SLC7A11/GPX4 pathway.
15 Oct 2026· Brain research bulletin· PUBMED
Publication
Artemether induces JNK1/FOXO1/GPX4-mediated ferroptosis to suppress colorectal cancer.
11 Oct 2026· Tissue & cell· PUBMED
Publication
Discovery of Dual PARP/GPX4 Inhibitors for the Treatment of Triple-Negative Breast Cancer.
8 Oct 2026· Journal of medicinal chemistry· PUBMED
Publication
SHMT2 Suppression Disrupts Redox Homeostasis and Induces Ferroptosis Through the GSH-GPX4 Axis in Head and Neck Cancer.
8 Oct 2026· Antioxidants (Basel, Switzerland)· PUBMED
Publication
Androgen receptor-regulated ZNF419 modulates ferroptosis sensitivity via the ZDHHC20-GPX4 pathway in prostate cancer.
8 Oct 2026· Redox biology· PUBMED
Publication
Multi-cell death gene signature predicts lung adenocarcinoma prognosis and reveals FURIN regulates ferroptosis via NRF2-xCT-GPX4 axis.
5 Oct 2026· Respiratory research· PUBMED
Publication
Dendrobium Officinale Polysaccharide Inhibits Ferroptosis and Ameliorates Cerebral Ischemia-Reperfusion Injury: Involvement of the Nrf2/GPX4 Signaling Pathway.
5 Oct 2026· Molecular neurobiology· PUBMED
Publication
Ru3: a novel ruthenium-based compound overcomes cisplatin resistance in non-small cell lung cancer via the E2F2-IGFBP3-GPX4 pathway.
3 Oct 2026· Apoptosis : an international journal on programmed cell death· PUBMED
Publication
Aspirin eugenol ester attenuates alcoholic liver injury via the NRF2/SLC7A11/GPX4 pathway-mediated ferroptosis suppression.
1 Oct 2026· Phytomedicine : international journal of phytotherapy and phytopharmacology· PUBMED
Publication
GPX4-Mediated Inhibition of Ferroptosis by Sodium Selenite Ameliorates Bone Metabolic Disorders in Ovariectomized Mice.
1 Oct 2026· Journal of cellular and molecular medicine· PUBMED
Publication
Glutathione-Driven Redox Inducer with Disruption of the SLC7A11/GSH/GPX4 Axis for Enhanced Ferroptotic Therapy.
29 Sept 2026· Langmuir : the ACS journal of surfaces and colloids· PUBMED
Publication
Single-cell transcriptomics identifies PRDX1 and GPX4 as potential ferroptosis regulators and tumor microenvironment--related molecules in hepatocellular carcinoma.
29 Sept 2026· Oncology letters· PUBMED
Publication
Targeting GPX4 and FSP1 to exploit ferroptotic vulnerability in Ewing sarcoma.
28 Sept 2026· Frontiers in oncology· PUBMED
Publication
Degrading GPX4 via Biomimetic Nanoparticle-Mediated In Situ Synthesis of Deep-Learning-Designed Binder-Degron Chimeras for Prostate Cancer Therapy.
27 Sept 2026· Advanced science (Weinheim, Baden-Wurttemberg, Germany)· PUBMED
Publication
A candidate PPARγ to GPX4 axis in ferroptosis suppression and platinum resistance in bladder cancer: evidence appraisal and a testable research agenda.
24 Sept 2026· Journal of Cancer· PUBMED
Publication
Empagliflozin attenuates PTZ-induced neurotoxicity and enhances the protective effects of levetiracetam: Associations with NRF2/GPX4 and AMPK/ULK1/ LC3-II signaling.
22 Sept 2026· Neurotoxicology· PUBMED
Publication
Advanced glycation end products promote ferroptotic injury in human renal tubular epithelial cells through the miR-362-3p/SLC7A11/GPX4 Axis.
21 Sept 2026· Life sciences· PUBMED
Publication
Ferroptosis in Neurodegenerative Diseases: Iron Dysregulation, GPX4/FSP1 Signaling, and Emerging Neuroprotective Strategies.
17 Sept 2026· Current neurovascular research· PUBMED
Publication
Hinokitiol as a Potential GPX4 Allosteric Modulator to Prevent Ferroptosis-mediated Neurodegeneration in Parkinson's Disease.
17 Sept 2026· Neurochemical research· PUBMED
Publication
USP8 stabilizes GPR37 via deubiquitination to regulate colorectal cancer progression through the NRF2/SLC7A11/GPX4 pathway.
17 Sept 2026· Cytotechnology· PUBMED

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