New trials, publications, preprints and grants on this target, month by month.
Publication
Anticancer activity of sodium propionate in hepatocellular carcinoma cells via downregulation of HDAC2 and HDAC6.
6 Nov 2026· Journal of computer-aided molecular design· PUBMED
Publication
Salidroside alleviates MPP+-induced injury and mitochondrial fission in PC12 cells by mediating the HDAC6/MST1/MIEF1 axis.
6 Nov 2026· The International journal of neuroscience· PUBMED
Publication
Integrative miRNA-multi-omics analysis of brain-metastasis predisposition in non-small cell lung cancer prioritizes HDAC inhibitors and anti-miR-330-3p as hypothesis-generating therapeutic candidates.
5 Nov 2026· Functional & integrative genomics· PUBMED
Publication
HDAC inhibition drives NOX5-dependent oxidative stress and sensitizes uveal melanoma cells to SOD1 inhibition.
2 Nov 2026· The Journal of biological chemistry· PUBMED
Publication
FAM60A Regulates SIN3A-HDAC Complex Activity to Induce G1/S Phase Arrest and Promote Differentiation of Low-Grade Glioma.
1 Nov 2026· Biology of the cell· PUBMED
Publication
Recent Progress in HDAC-Based Dual-Target Inhibitors for Colorectal Cancer.
1 Nov 2026· Drug development research· PUBMED
Publication
New sulfonamide derivatives as HDAC inhibitors and apoptosis inducers: design, synthesis, in silico study and anticancer evaluation.
27 Oct 2026· RSC advances· PUBMED
Publication
Structure-Based Design of HDAC6 Inhibitors Targeting the L2 Pocket: Modulating Autophagy and Liquid-Liquid Phase Separation in Lung Cancer.
22 Oct 2026· Journal of medicinal chemistry· PUBMED
Publication
Design, Synthesis, Molecular Docking, and Anticancer Activity Evaluation of Chalcone Derivatives as HDAC6 Inhibitors.
21 Oct 2026· Die Pharmazie· PUBMED
Publication
Differential Regulation of Cholesterol-Related Gene Expression by HDAC Inhibition in Neuron-Enriched and Glia-Enriched Rat Primary Cultures.
17 Oct 2026· International journal of molecular sciences· PUBMED
Publication
Editor's Note: Ubiquitin Proteasome System Stress Underlies Synergistic Killing of Ovarian Cancer Cells by Bortezomib and a Novel HDAC6 Inhibitor.
15 Oct 2026· Clinical cancer research : an official journal of the American Association for Cancer Research· PUBMED
Publication
Disabling COMPASS Promoter Licensing Shifts HDAC-Inhibited Gastric Cancer Toward Sustained Transcriptional Suppression During Recovery.
15 Oct 2026· Advanced science (Weinheim, Baden-Wurttemberg, Germany)· PUBMED
Publication
Restoring Neural Homeostasis via Class II HDAC Modulation: Mechanistic Insights and Therapeutic Opportunities.
15 Oct 2026· Molecular neurobiology· PUBMED
Publication
Discovery of a Novel HDAC1 Inhibitor to Potentiate Ferroptosis with Arachidonic Acid in ESCC.
8 Oct 2026· Journal of medicinal chemistry· PUBMED
Preprint
Combined HDAC and ATM inhibition with radiation in preclinical glioblastoma models.
7 Oct 2026· bioRxiv : the preprint server for biology· PUBMED
Publication
A Patient-Derived Screen Identifies HDAC Inhibitors as Enhancers of Phagocytosis and Potent Immunotherapy Partners.
5 Oct 2026· Cancer immunology research· PUBMED
Publication
Targeting the DNHD1‑HDAC6 axis inactivates prostate cancer cell aggressiveness in vitro, suggesting potential therapeutic vulnerability.
2 Oct 2026· Oncology reports· PUBMED
Publication
HDAC Inhibition Unlocks Tumor Plasticity and Enhances Immunotherapy Response in Myc-Driven Small Cell Lung Cancer.
2 Oct 2026· Molecular cancer therapeutics· PUBMED
Publication
Corrigendum to "Effect and mechanism of novel HDAC inhibitor ZDLT-1 in colorectal cancer by regulating apoptosis and inflammation" [Int. Immunopharmacol. 143 (2024) 113333].
28 Sept 2026· International immunopharmacology· PUBMED
Publication
Substituted methyl acridone-carboxylate derivatives as CD1/CD2 dual-targeting HDAC6 inhibitors to ameliorate the pathological phenotype of Alzheimer's disease.
19 Sept 2026· European journal of medicinal chemistry· PUBMED
Publication
Novel Class I HDAC Inhibitors Sensitize Ovarian Cancer Cells for Cisplatin and Niraparib via an HDAC3-SLFN11 Axis.
18 Sept 2026· ACS chemical biology· PUBMED
Publication
Astragaloside IV alleviates heart failure by restoring gut microbiota-derived short-chain fatty acids and suppressing HDAC1/2/3.
16 Sept 2026· Biochemical and biophysical research communications· PUBMED
Publication
Rapid Two-Step Multicomponent Synthesis and Structure-degradation Relationships of Selective HDAC6 PROTAC Degraders.
10 Sept 2026· Journal of medicinal chemistry· PUBMED
Publication
Gut microbiota as a modulator of HDAC: insights into Alzheimer's disease treatment.
9 Sept 2026· Pharmacological reports : PR· PUBMED
Publication
Design, synthesis, and screening of novel thienopyrimidine derivatives as PI3K/HDAC dual inhibitors against cervical cancer cells.
8 Sept 2026· European journal of medicinal chemistry· PUBMED
Publication
USP19 facilitates CSE-induced cell damage and ferroptosis in chronic obstructive pulmonary disease by deubiquitinating HDAC6 to drive PRDX6 deacetylation.
8 Sept 2026· Immunologic research· PUBMED
Publication
Imidazo[1,2-a]pyridine-based HDAC6 inhibitor a17 for the treatment of Alzheimer's disease.
5 Sept 2026· European journal of pharmacology· PUBMED
Publication
Machine Learning and Molecular Modeling Reveal HDAC6 as a Key Target of Tanshinone IIA in Multiple Myeloma.
3 Sept 2026· The journal of physical chemistry. B· PUBMED
Publication
HDAC1 lactylation drives diabetic retinopathy by orchestrating a pro-angiogenic epigenetic program.
2 Sept 2026· Cell reports· PUBMED
Publication
Sotagliflozin, a Dual SGLT1/2 Inhibitor, Modulates DNMT1 and Class I/II HDAC Expression in Association With Anticancer Effects in Breast and Lung Cancer Cells.
1 Sept 2026· Cell biology international· PUBMED