Target

HIF-1

Hypoxia-inducible factor 1

Also: HIF-1α, HIF1A, HIF1α

3open trials
6trials in total
575publications
0researchers

Diseases

The last 24 months

New trials, publications, preprints and grants on this target, month by month.

TrialsPublicationsPreprintsGrants

Publication
HIF-1α/PPAR-γ/SIRT1 axis drives astrocyte senescence and regulates endothelial function via GDNF/NRTN in diabetic retinopathy.
6 Nov 2026· PloS one· PUBMED
Publication
Gastrodin Attenuates Neuroinflammation and Depressive-Like Phenotypes via Modulation of the PHD2-HIF-1α/Glycolysis Axis.
5 Nov 2026· Journal of ethnopharmacology· PUBMED
Publication
Statement of Retraction: Induction of lncRNA NORAD accounts for hypoxia-induced chemoresistance and vasculogenic mimicry in colorectal cancer by sponging the miR-495-3p/ hypoxiainducible factor-1α (HIF-1α).
5 Nov 2026· Bioengineered· PUBMED
Publication
Inulin- and Butyrate-Mediated HIF-1α Butyrylation Prevent Diabetic Ferroptosis and Cardiomyopathy by Maintaining Iron Homeostasis.
1 Nov 2026· Diabetes· PUBMED
Publication
HOXC9 promotes gastric cancer cell proliferation, invasion, and migration via regulating HIF-1 pathway.
1 Nov 2026· Gene· PUBMED
Publication
Identification of biomarkers to guide treatment strategies toward precision medicine in hepatocellular carcinoma: Editorial on "ERBB3 blockade sensitizes HCC to regorafenib after first-line TKI resistance by inhibiting HIF1A-ABCB1 signaling".
29 Oct 2026· Clinical and molecular hepatology· PUBMED
Publication
Baicalin alleviates renal interstitial fibrosis by targeting SIRT1/HIF-1α signaling pathway.
27 Oct 2026· Journal of ethnopharmacology· PUBMED
Publication
Exosomal miR-146a-3p from BEAS-2B cells alleviates NETs-Aggravated asthma by targeting HIF-1α to inhibit ferroptosis.
26 Oct 2026· Redox biology· PUBMED
Publication
ERO1A promotes lung cancer progression via HIF1A/EGFR.
24 Oct 2026· Cellular signalling· PUBMED
Publication
Siwuyin Inhibits Esophageal Cancer Metastasis by Modulating PHD 2/3-HIF1α Signal Pathway Mediated by Fumaric Acid.
24 Oct 2026· Chinese journal of integrative medicine· PUBMED
Publication
Phloretin Ameliorates Rheumatoid Arthritis by Suppressing HIF-1α-Dependent Angiogenesis and Modulating of the Autophagy-Apoptosis Balance.
23 Oct 2026· Phytotherapy research : PTR· PUBMED
Publication
TRIM65-BTG3-HIF-1α axis drives osteosarcoma progression via M2 macrophage polarization and angiogenesis.
23 Oct 2026· Journal of translational internal medicine· PUBMED
Publication
Hypoxia-induced GP73 promotes the Warburg effect in hepatocellular carcinoma via HIF-1α.
22 Oct 2026· Molecular biology reports· PUBMED
Publication
HIF-1α-driven protein lactylation promotes ferroptosis and lipid peroxidation in ulcerative colitis and is suppressed by quercetin.
20 Oct 2026· Experimental cell research· PUBMED
Publication
Editor's Note: ERK Regulates HIF1α-Mediated Platinum Resistance by Directly Targeting PHD2 in Ovarian Cancer.
15 Oct 2026· Clinical cancer research : an official journal of the American Association for Cancer Research· PUBMED
Publication
miR‑18a‑5p Serves as a Diagnostic and Prognostic Biomarker and Attenuates Hypoxia‑Induced Cardiac Microvascular Endothelial Injury by Targeting the HIF1A/NF‑κB Pathway in Chronic Heart Failure.
15 Oct 2026· Cardiovascular drugs and therapy· PUBMED
Publication
SLMO2 promotes chemoresistance in glioblastoma by regulating BNIP3-dependent mitophagy via the NF-κB/HIF-1α axis.
14 Oct 2026· Pharmacological research· PUBMED
Publication
Hypoxic conditioning of neuroblastoma cells promotes CD8+ T-cell dysfunction through the HIF-1α/PD-L1 axis.
14 Oct 2026· Frontiers in pediatrics· PUBMED
Publication
Targeting the HIF-1α-BSG metabolic circuit reverses enzalutamide resistance in prostate cancer.
13 Oct 2026· Cellular signalling· PUBMED
Publication
CXCL8⁺HIF-1α⁺ macrophages define a disease-associated myeloid state during colorectal tumorigenesis.
9 Oct 2026· Cancer genetics· PUBMED
Publication
H4K12 Lactylation Impairs Dopaminergic Neuron Energy Metabolism via the HIF-1α/NDUFS1 Pathway in Parkinson's Disease.
8 Oct 2026· Advanced science (Weinheim, Baden-Wurttemberg, Germany)· PUBMED
Publication
Waterpipe Smoke Condensate Impairs p53 Nuclear Localization in Association with HIF-1α Stabilization.
8 Oct 2026· International journal of molecular sciences· PUBMED
Publication
Alpinia oxyphylla Miq. promotes angiogenesis and preserves neurons in subacute ischemic stroke in rats: possible involvement of the HIF-1α/Nrf2/VEGF-A-mediated signaling pathway.
6 Oct 2026· Journal of ethnopharmacology· PUBMED
Publication
Berberine increases the sensitivity of sorafenib in human hepatocellular carcinoma via inducing HIF-1α-mediated energy crisis.
4 Oct 2026· Phytomedicine : international journal of phytotherapy and phytopharmacology· PUBMED
Publication
Icariin synergistically inhibits glycolysis and mitochondrial energy metabolism in lung cancer in association with the HIF-1α/LONP1 axis.
3 Oct 2026· Tissue & cell· PUBMED
Publication
Mechanism of luteolin in treating chronic heart failure by regulating HIF-1 signaling pathway-mediated mitochondrial damage to inhibit cardiomyocyte apoptosis.
2 Oct 2026· Frontiers in cell and developmental biology· PUBMED
Publication
Securidaca inappendiculata Extract Mitigates Joint Damage in Collagen-Induced Arthritis Rats Through Modulation of the SIRT1/HIF-1α/Glycolysis Pathway.
1 Oct 2026· Pharmacology research & perspectives· PUBMED
Publication
Association of Three HIF-1α Genotypes With Susceptibility and Severity of Chronic Kidney Disease.
1 Oct 2026· Clinical and translational science· PUBMED
Publication
The effect of the interplay between PGC-1α and HIF-1α on preserving mitochondrial metabolism in diabetic kidney disease.
1 Oct 2026· Kidney research and clinical practice· PUBMED
Publication
ITGB2 promotes HIF-1α/GLUT1 mediated glucose metabolic reprogramming in renal tubular epithelial cells to aggravate the progression of diabetic kidney disease.
1 Oct 2026· Cytotechnology· PUBMED

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