New trials, publications, preprints and grants on this target, month by month.
Publication
Hepatocyte growth factor activator (HGFA) released from human HSC-3 oral cancer spheroids potentiates M2 polarization and autophagy of THP-1 differentiated macrophages.
4 Nov 2026· Human cell· PUBMED
Publication
Hsa_Circ_0000615-Encoded 250-Amino Acid Polypeptide Suppresses Epithelial Ovarian Cancer Progression via Promoting HMGB1 Nuclear Accumulation.
28 Oct 2026· Oncology research· PUBMED
Publication
Pharmacological Modulation of HMGB1/TLR-4/NF-κB Signaling Axis in 3-Nitropropionic Acid-Induced Neurotoxicity in Experimental Animals.
28 Oct 2026· Rejuvenation research· PUBMED
Publication
Subacute administration of human umbilical cord-derived mesenchymal stem cells is associated with neurobehavioral improvement, myeloid immune modulation, and altered HMGB1 dynamics after experimental ischemic stroke.
26 Oct 2026· Brain research· PUBMED
Publication
Altered HMGB1-TLR4-NF-κB Signaling and regulatory microRNA expression in idiopathic generalized epilepsy according to Toxoplasma gondii serostatus.
24 Oct 2026· Journal of neuroimmunology· PUBMED
Publication
Erratum: CSNK2A1-mediated MAX phosphorylation upregulates HMGB1 and IL-6 expression in cholangiocarcinoma progression.
23 Oct 2026· Hepatology communications· PUBMED
Publication
HMGB1 directly activates BAP1 transcription to sustain tumor growth in mesothelioma.
23 Oct 2026· Cell death and differentiation· PUBMED
Publication
Targeting TLR4 alleviates the progression of experimental autoimmune encephalomyelitis by regulating central resident cells and Th1/Th17 cell differentiation.
16 Oct 2026· Frontiers in immunology· PUBMED
Publication
Adipose-derived mesenchymal stem cell-derived exosomal miR-22-3p alleviates depression-like behaviors in a rat model via the FURIN/HMGB1 axis.
13 Oct 2026· Frontiers in pharmacology· PUBMED
Publication
Baseline Serum HMGB1 and the Composite of All-Cause Mortality or First Heart Failure Rehospitalization in Heart Failure with Preserved Ejection Fraction.
13 Oct 2026· Journal of inflammation research· PUBMED
Publication
Association of miRNA-500 and AGE-RAGE axis in the development of thyroid cancer.
10 Oct 2026· Endocrine· PUBMED
Publication
ECM stiffness inhibits ferroptosis to promote HCC progression via the FOXA1-CDON-HMGB1/p53 pathway.
9 Oct 2026· International journal of biological sciences· PUBMED
Publication
Ferulic acid-mediated selenium nanoparticles attenuate oxaliplatin-induced renal injury in type 2 diabetic rats via modulation of oxidative stress, SIRT1/HMGB1/TLR4 signaling, endoplasmic reticulum stress, and apoptosis.
4 Oct 2026· Tissue & cell· PUBMED
Publication
Protocatechualdehyde ameliorates temporal lobe epilepsy via synergistic regulation of HMGB1-TLR4-NF-κB pathway and metabolic reprogramming.
1 Oct 2026· Journal of ethnopharmacology· PUBMED
Publication
When the Brain Signals Danger: Roles of Calreticulin and HMGB1 in Cell Death Mechanisms in Neurooncology and Neurodegeneration.
1 Oct 2026· Biochemistry. Biokhimiia· PUBMED
Publication
Peripheral HMGB1 Downregulation Is Associated With the S100-IL-17 Axis in Parkinson's Disease: An Integrated Bulk and Single-Cell Transcriptomic Analysis.
30 Sept 2026· Parkinson's disease· PUBMED
Publication
HMGB1 functional plasticity in neurodegenerative diseases and its translational implications.
29 Sept 2026· Frontiers in immunology· PUBMED
Publication
HMGB1 in Amyloid-Beta Pathology: Mechanistic Insights and Therapeutic Implications for Alzheimer's Disease.
28 Sept 2026· International journal of molecular sciences· PUBMED
Publication
TGF-β2 promotes autophagy-mediated resistance to doxorubicin in metastatic colon cancer cells via HMGB1.
25 Sept 2026· Medical oncology (Northwood, London, England)· PUBMED
Publication
Shenghui Decoction ameliorates cognitive impairment and neuroinflammation in APP/PS1 mice via modulation of the HMGB1/TLR4/NLRP3 pathway.
24 Sept 2026· Journal of ethnopharmacology· PUBMED
Publication
Erythropoietin-derived peptide (HBSP) inhibits caspase-3/GSDME through HMGB1 to regulate pyroptosis and reduce diabetic retinopathy.
23 Sept 2026· Peptides· PUBMED
Publication
Tumor-cell HMGB1 restrains CD8+ T-cell immunity during conventional fractionated radiotherapy.
19 Sept 2026· Cancer letters· PUBMED
Publication
Peripheral Inflammatory Biomarkers in Chronic Autoimmune-Associated Epilepsy: An Exploratory Case-Control Study.
16 Sept 2026· Biomolecules· PUBMED
Publication
HMGB1 Post-Translational Modifications in Epstein-Barr Virus-Associated Nasopharyngeal Carcinoma: Current Evidence, Emerging Mechanistic Concepts, and Unresolved Questions.
15 Sept 2026· International journal of molecular sciences· PUBMED
Publication
Melatonin exerts an in vitro anti-glioblastoma effect through SIRT1-mediated HMGB1 deacetylation and inhibition of the TLR4/NF-κB pathway.
14 Sept 2026· Oncology letters· PUBMED
Publication
Neutrophil Senescence Induced by Tumor-Derived HMGB1 Promotes Hepatocellular Carcinoma Progression through Neutrophil Extracellular Trap-Mediated Suppression of CD8+ T Cell Immunity.
11 Sept 2026· Cancer communications (London, England)· PUBMED
Publication
Sphallerocarpus gracilis Polyphenols Alleviate DSS-Induced Colitis by Remodeling Gut Microbiota and Inhibiting the AGE-RAGE/HMGB1 Pathway.
7 Sept 2026· Antioxidants (Basel, Switzerland)· PUBMED
Publication
Damage-Associated Molecular Patterns in Mesothelioma: Drivers of Inflammation and Therapeutic Targets.
2 Sept 2026· International journal of molecular sciences· PUBMED
Publication
HMGB1 as a convergent host factor in virus-induced carcinogenesis.
2 Sept 2026· Biochemical and biophysical research communications· PUBMED
Publication
Discovery and synthesis of 3-amino glycyrrhizin derivative containing guanidyl with anti-colorectal cancer activity.
1 Sept 2026· Chinese journal of natural medicines· PUBMED