HSP90

Diseases

• ALS (motor neurone disease)1 trial
• Alzheimer disease1 trial
• Parkinson disease1 trial

The last 24 months

New trials, publications, preprints and grants on this target, month by month.

TrialsPublicationsPreprintsGrants

• Publication

  Dihydrotanshinone I in Paired Vemurafenib-Sensitive and Resistant A375 Melanoma Cells.

  5 Nov 2026· Journal of visualized experiments : JoVE· PUBMED

• Publication

  Phase Separation of ZBED2 Stabilizes ILK to Drive Metastasis and Immune Evasion in Esophageal Squamous Cell Carcinoma.

  3 Nov 2026· Cancer research· PUBMED

• Publication

  Network Pharmacology Identifies Stigmasterol as an Anti-Gastric Cancer Agent Targeting HSP90AA1 for Ubiquitin-Mediated Degradation.

  3 Nov 2026· Journal of visualized experiments : JoVE· PUBMED

• Publication

  Editor's Note: A Novel HSP90 Inhibitor Delays Castrate-Resistant Prostate Cancer without Altering Serum PSA Levels and Inhibits Osteoclastogenesis.

  2 Nov 2026· Clinical cancer research : an official journal of the American Association for Cancer Research· PUBMED

• Publication

  Molecular mechanisms, functional diversity, and therapeutic implications of HSP90 isoforms in lung cancer.

  29 Oct 2026· Molecular biology reports· PUBMED

• Publication

  Elucidating the toxicogenomic mechanisms of DBP exposure on Hepatocellular carcinoma through network toxicology and molecular docking analysis.

  28 Oct 2026· PloS one· PUBMED

• Publication

  Licochalcone A Inhibits Melanoma Cell Survival by Suppressing HSP75 (TRAP1) and Disrupting Cellular Redox and Energy Homeostasis.

  14 Oct 2026· International journal of molecular sciences· PUBMED

• Publication

  Glyceraldehyde May Induce the Generation of High-Molecular-Weight Species of HSP90β and Autophagy-Related Proteins and Alter Protein Levels in Human Renal Epithelial Cells.

  13 Oct 2026· Biomolecules· PUBMED

• Publication

  An Exosome-Based Affinity Screening Platform for Identifying Bioactive Compounds against Colon Cancer.

  6 Oct 2026· Analytical chemistry· PUBMED

• Publication

  Investigation of the Mechanism of Lorlatinib-Induced Hepatotoxicity: Reactive Metabolites of Lorlatinib Activate Inflammasomes.

  21 Sept 2026· Chemical research in toxicology· PUBMED

• Publication

  Correction: Celastrol ameliorates ulcerative colitis by inhibiting HSP90-mediated necroptosis of intestinal epithelial cells.

  21 Sept 2026· Frontiers in pharmacology· PUBMED

• Publication

  HSP90 shields ROC1/RBX1 from proteasomal degradation by CHIP E3 ubiquitin ligase to promote lung adenocarcinoma.

  21 Sept 2026· Signal transduction and targeted therapy· PUBMED

• Publication

  Ovarian tumor domain-containing protein 1 deficiency attenuates metabolic dysfunction-associated steatotic liver disease by promoting the ubiquitination of HSP90α in hepatocytes.

  20 Sept 2026· Molecular biomedicine· PUBMED

• Publication

  Estrogens hypersensitivity syndrome in endometriosis.

  19 Sept 2026· Endocrine regulations· PUBMED

• Publication

  Single-Cell RNA Sequencing Reveals Immune Dysregulation and Candidate Drug Targets in Endometriosis.

  19 Sept 2026· Cells· PUBMED

• Publication

  Targeting ITIH3 inhibits oxidative stress and autophagy in renal tubular epithelial cells by regulating the HSP90B1/STAT3 axis, thereby alleviating diabetic nephropathy injury.

  12 Sept 2026· Archives of biochemistry and biophysics· PUBMED

• Publication

  MSTO1 promotes hepatocellular carcinoma progression and represents a potential target for immunotherapy.

  5 Sept 2026· International immunopharmacology· PUBMED

• Publication

  Biohybrid nanovesicle-mediated targeted delivery of HSP90 inhibitor for enhanced sorafenib therapy of hepatocellular carcinoma after radiofrequency ablation.

  3 Sept 2026· Materials today. Bio· PUBMED

• Publication

  AHA1 Regulates Aβ Production via Modulation of APP Abundance and γ-Secretase Assembly.

  1 Sept 2026· Journal of neurochemistry· PUBMED

• Publication

  Cell-specific cPGES control of glucocorticoid receptor function drives MASLD progression.

  27 Aug 2026· Cell reports· PUBMED

• Publication

  Dual MAO A and HSP90 inhibitors enhance anti-PD-1 therapy and suppress colorectal cancer.

  24 Aug 2026· Frontiers in pharmacology· PUBMED

• Publication

  Celastrol ameliorates ulcerative colitis by inhibiting HSP90-mediated necroptosis of intestinal epithelial cells.

  21 Aug 2026· Frontiers in pharmacology· PUBMED

• Publication

  Discovery of a Novel HSP90-Targeting Inhibitor for AML from the Marine Aaptamine Scaffold.

  13 Aug 2026· Journal of medicinal chemistry· PUBMED

• Publication

  Adipocyte-derived β-hydroxybutyrate confers metabolic resilience in multiple myeloma.

  11 Aug 2026· Nature communications· PUBMED

• Publication

  Astrocytic HSP90AA1 Upregulation and Altered Synaptic Signaling in Parkinson's Disease: Transcriptomic Screening and In Vivo Validation.

  9 Aug 2026· International journal of molecular sciences· PUBMED

• Publication

  NLRC3 suppresses hepatocarcinogenesis by disrupting the HSP90-mediated TRAF6/MYC signalling activation.

  3 Aug 2026· Biochimica et biophysica acta. Molecular basis of disease· PUBMED

• Publication

  Diagnostic and Prognostic Values of Microfibrillar-Associated Protein 5 and Heat Shock Protein 90 Alpha in Patients with HCV-Induced Hepatocellular Carcinoma Undergoing Locoregional Therapy.

  1 Aug 2026· Asian Pacific journal of cancer prevention : APJCP· PUBMED

• Publication

  Deep-learning-enabled multi-omics analyses for prediction of future metastasis in cancer.

  1 Aug 2026· Nature communications· PUBMED

• Publication

  Targeting the HSP90/miR-656 axis to suppress lung cancer stem cells and overcome autophagy-mediated drug resistance in non-small cell lung cancer.

  30 Jul 2026· European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences· PUBMED

• Publication

  Isoform-selective HSP90 inhibition as a precision therapeutic strategy for neurodegenerative and metabolic diseases.

  27 Jul 2026· Progress in neuro-psychopharmacology & biological psychiatry· PUBMED

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