New trials, publications, preprints and grants on this target, month by month.
Publication
IDO1 methylation by EZH2 confers resistance to its targeted therapy in colorectal cancer through tryptophan-kynurenine metabolic rewiring.
5 Nov 2026· Cell reports· PUBMED
Publication
ShenqiYichang decoction enhances colorectal cancer immune efficacy via IDO1 mediated reduction of Treg infiltration.
14 Oct 2026· Journal of ethnopharmacology· PUBMED
Publication
IDO1 integrates gut microbiota-derived SCFAs signals and host WNT/TGF-β pathways to mediate the anti-colorectal cancer effects of licorice flavonoids.
23 Sept 2026· Pharmacological research· PUBMED
Publication
CPT1A-mediated IDO1 succinylation shapes EGFRvIII-driven resistance to tumor electric field therapy in glioblastoma.
23 Sept 2026· Nature communications· PUBMED
Publication
Phase 1 study of KHK2455, a long-acting, potent and selective IDO1 inhibitor, in combination with avelumab in patients with locally advanced or metastatic urothelial carcinoma.
21 Sept 2026· Journal for immunotherapy of cancer· PUBMED
Publication
Design and Computational Evaluation of Isatin Derivatives as Dual MAO-A/IDO1 Inhibitors: Molecular Docking and Molecular Dynamics Insights.
21 Sept 2026· Current medicinal chemistry· PUBMED
Publication
Astaxanthin alleviates Parkinson's disease via dual regulation of tryptophan metabolism: central STAT3/IDO1 inhibition and gut microbiota remodeling.
14 Sept 2026· Food research international (Ottawa, Ont.)· PUBMED
Publication
[Mechanistic study on Kaixin Powder ameliorating chronic stress-induced CD8~+T cell exhaustion and delaying lung adenocarcinoma progression by modulating IDO1/Kyn/Ahr axis].
1 Sept 2026· Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica· PUBMED
Publication
Design, synthesis, antitumor estimation, and molecular docking of new imidazothiazolediones as potential dual EGFR and IDO1 inhibitors and apoptosis stimulators.
27 Aug 2026· Bioorganic & medicinal chemistry· PUBMED
Publication
Tanshinone IIA restores CD8+ T-cell immunity in TNBC by suppressing the IDO1-kynurenine axis.
25 Aug 2026· Frontiers in pharmacology· PUBMED
Publication
Phase I Evaluation of Patients with Newly Diagnosed Glioblastoma Treated with Radiation, Nivolumab, and IDO1 Enzyme Inhibitor BMS-986205.
14 Aug 2026· Clinical cancer research : an official journal of the American Association for Cancer Research· PUBMED
Publication
IDO1 Silencing Enhances Cisplatin Sensitivity in Gastric Cancer Cells via Modulation of Apoptosis and Oxidative Stress.
27 Jul 2026· Current issues in molecular biology· PUBMED
Publication
Targeting the AHR-IDO1-kynurenine pathway in TREM2+ macrophages restores antitumor immunity in thyroid cancer.
21 Jul 2026· Frontiers in immunology· PUBMED
Publication
Split immunomodulatory impact of leptin on human myeloid cells: key role of IDO1 in counteracting the immunostimulatory effect of leptin.
10 Jul 2026· Journal of immunology (Baltimore, Md. : 1950)· PUBMED
Publication
Immune evasion in locally advanced mismatch repair-deficient microsatellite instability-high colorectal cancer: Reduced T-cell infiltration and upregulation of epithelial IDO1 expression.
9 Jul 2026· Oncoimmunology· PUBMED
Publication
Corrigendum to "Erzhi pill enhances methotrexate efficacy in rheumatoid arthritis bone homeostasis via activation of the IDO1-KYN-AhR pathway" [Phytomedicine 157 (2026) 158290].
26 Jun 2026· Phytomedicine : international journal of phytotherapy and phytopharmacology· PUBMED
Publication
Serum IDO1 and β-catenin levels in patients with multiple sclerosis with and without atherosclerosis: A case-control study.
24 Jun 2026· Journal of neuroimmunology· PUBMED
Publication
20(S/R)-Ginsenoside Rh1 Alleviates AOM/DSS-Induced Colorectal Cancer: Gut-Microbiota Modulation and Tryptophan-Metabolism-Mediated AhR/PXR Activation and IDO1.
17 Jun 2026· International journal of molecular sciences· PUBMED
Publication
Cancer IDO1-Mediated Tryptophan-Kynurenine Metabolic Reprogramming to Drive Skeletal Muscle Atrophy and Cachexia Acceleration.
1 Jun 2026· Journal of cachexia, sarcopenia and muscle· PUBMED
Publication
Indoleamine 2,3-dioxygenase 1 (IDO1) promoted the activation of inflammatory response in the brain tissue of Alzheimer's disease mice by regulating NF-κB pathway.
19 May 2026· Neuroscience letters· PUBMED
Publication
Erzhi pill enhances methotrexate efficacy in rheumatoid arthritis bone homeostasis via activation of the IDO1-KYN-AhR pathway.
14 May 2026· Phytomedicine : international journal of phytotherapy and phytopharmacology· PUBMED
Publication
Clinical Significance of Serum CCR2 and IDO1 in Diabetic Peripheral Neuropathy.
25 Mar 2026· Diabetes, metabolic syndrome and obesity : targets and therapy· PUBMED
Publication
Increased LAG-3, TIM-3, and IDO1 Expression Is Associated With Oral Squamous Cell Carcinoma in Never Smokers and Never Drinkers.
19 Mar 2026· Oral diseases· PUBMED
Publication
Machine learning-driven drug discovery for the management of TNBC: focus on IDO1 and TDO targets.
17 Mar 2026· SAR and QSAR in environmental research· PUBMED
Publication
Nexus of IDO1/Kynurenine Pathway to T-Cell Exhaustion: Hypoxia-Induced Tryptophan Metabolism in Glioblastoma.
10 Mar 2026· Metabolites· PUBMED
Publication
The IDO1/AhR-HIF-1α metabolic axis: ARNT competition as a central antagonistic switch in autoimmune pathogenesis.
6 Mar 2026· Frontiers in immunology· PUBMED
Publication
Differential Effects of Saturated and Unsaturated Fatty Acids on Colorectal Cancer via IDO1 Signaling.
1 Mar 2026· Cancer medicine· PUBMED
Publication
Design, synthesis and anti-Parkinson's disease bioactivity evaluation of isoquinoline derivatives as potent IDO1/TDO dual inhibitors.
22 Feb 2026· Bioorganic & medicinal chemistry letters· PUBMED
Publication
Galangin-loaded biomimetic dendritic cells membrane nanovaccine reprograms the ovarian cancer microenvironment via Stat3/IDO1/AhR axis to boost immunotherapy.
10 Feb 2026· Materials today. Bio· PUBMED
Publication
Estrogen regulates cognitive function in APP/PS1 female mice via modulation of IDO1-mediated Trp/Kyn metabolism through ERβ.
9 Feb 2026· Hormones and behavior· PUBMED