New trials, publications, preprints and grants on this target, month by month.
Publication
β-elemene suppressed EMT via IGF1R inhibition in osimertinib treated AXL low-expressing EGFR mutant non-small cell lung cancer.
2 Nov 2026· European journal of pharmacology· PUBMED
Publication
Experimental high blood glucose metabolically rejuvenates CD8+ T cells for improved control of tumor growth through an IGF1-IGF1R axis.
1 Oct 2026· Journal of immunology (Baltimore, Md. : 1950)· PUBMED
Publication
IGF1R Induces ROS Formation in Mitochondria via MICU1 Leads to the Enzalutamide Resistance in Prostate Cancer.
1 Oct 2026· Journal of cellular and molecular medicine· PUBMED
Publication
Hypertension with defective IGF1R-PI3K signalling may trigger atrial cardiomyopathy, atrial fibrillation, and stroke.
22 Sept 2026· European heart journal· PUBMED
Publication
IGF1-IGF1R signaling in tumor-associated macrophages regulates extracellular matrix organization in BRAF inhibitor-targeted melanoma.
31 Aug 2026· Molecular and cellular biochemistry· PUBMED
Publication
PD-L1 upregulated by IGF1R via the PI3K/AKT/NF-κB axis induces sorafenib resistance in hepatocellular carcinoma.
21 Aug 2026· Molecular immunology· PUBMED
Publication
Delayed growth of SK-ES-1 Ewing sarcoma tumor xenografts is associated with reduced Trk and IGF1R pathway markers.
7 Aug 2026· Oncotarget· PUBMED
Publication
Growth factor receptors IGF-1R and VEGFR2 are associated with the prognosis of patients with esophageal cancer after esophagectomy.
27 Jul 2026· Open life sciences· PUBMED
Publication
Overcoming IGF1R-mediated resistance to oncolytic HSV1 and radiotherapy via triple combination therapy.
17 Jul 2026· Cell death & disease· PUBMED
Publication
TMEM216 inhibits breast cancer lung metastasis by modulating IGF1R-IRS4 signaling pathway.
1 Jul 2026· Nature communications· PUBMED
Publication
MALAT1 promotes autophagy via the mir-28-5p/IGF1R axis in nasopharyngeal carcinoma.
26 Jun 2026· Medical oncology (Northwood, London, England)· PUBMED
Publication
Erratum: [Corrigendum] Wentilactone A induces cell apoptosis by targeting AKR1C1 gene via the IGF-1R/IRS1/PI3K/AKT/Nrf2/FLIP/Caspase-3 signaling pathway in small cell lung cancer.
22 Jun 2026· Oncology letters· PUBMED
Publication
Exosomal miRNA-714 derived from adipose tissue macrophages regulates adipocyte glucose and lipid metabolism via IGF1R targeting.
22 Jun 2026· Nutrition & metabolism· PUBMED
Publication
[The Effect of MiR-100-5p on the Biological Behaviors of Pediatric Acute Myeloid Leukemia Cells by Targeting IGF1R].
1 Jun 2026· Zhongguo shi yan xue ye xue za zhi· PUBMED
Publication
Electroacupuncture Improves the Learning and Memory by Modulating Hippocampal Glucose Metabolism through IGF1/IGF1R Signaling in Alzheimer's Disease.
23 May 2026· Advanced science (Weinheim, Baden-Wurttemberg, Germany)· PUBMED
Publication
Insulin-like Growth Factor 1 Ameliorates Intestinal Barrier Dysfunction in MASLD via IGF-1R/PI3K/AKT Signaling.
22 May 2026· Nutrients· PUBMED
Publication
Loss of IGF-1R impairs DNA-PKcs recruitment to chromatin leading to defective end-joining.
7 May 2026· Molecular oncology· PUBMED
Publication
miR-449b-5p from adipose-derived mesenchymal stem cell-derived exosomes targets IGF1R to alleviate airway inflammation and improve airway smooth muscle cell dysfunction in children with asthma.
15 Apr 2026· Journal of immunology (Baltimore, Md. : 1950)· PUBMED
Publication
Nuclear Translocation of IGF1R Induces Cell Cycle Re-entry via Cyclin D1 Regulation in an Aβ-Driven Alzheimer's Disease Model.
15 Apr 2026· Molecular neurobiology· PUBMED
Publication
IGF1/IGF-1R promotes hepatocellular carcinoma progression by activating the Akt/GSK-3β pathway.
9 Apr 2026· PloS one· PUBMED
Publication
Tumor-specific lncRNA IGF1R-AS1 trans-regulates chromatin interactions associated with oncogenic MYC signaling.
19 Mar 2026· Nature communications· PUBMED
Publication
Network analysis-guided drug repurposing: IGF1R as a novel melanoma target and therapeutic potential of dapagliflozin.
17 Mar 2026· Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences· PUBMED
Publication
Myrtenol from Lavender Essential Oil Possesses Neuroprotective Effects and Promotes Neurite Outgrowth by Potentially Targeting TrkA and IGF-1R in PC12 Cells.
12 Mar 2026· International journal of molecular sciences· PUBMED
Publication
Apoptosis induction and migration suppression through regulation of IGF-1R/FoxO signaling pathways in Panc1 pancreatic cancer cells by hAMSCs secretome: An in vitro cell-based therapy.
10 Mar 2026· Cancer treatment and research communications· PUBMED
Publication
Small-nucleolar RNA host gene3 (SNHG3) and leukemia-associated non-coding IGF1R activator RNA 1 (LUNAR1) correlated with CRC patients' clinical features: a step-toward ncRNA-precision.
26 Feb 2026· Scientific reports· PUBMED
Publication
MUC15 loss promotes perineural invasion in pancreatic cancer by activating the IGF1R/STAT3/NGF pathway.
23 Feb 2026· Cancer letters· PUBMED
Publication
HOTAIR promotes the progression of B-cell acute lymphoblastic leukemia by regulating the miR-326/IGF-1R axis and activating the PI3K/AKT signaling pathway.
16 Feb 2026· Hematology (Amsterdam, Netherlands)· PUBMED
Publication
Dual targeting of IGF-1R and K-RAS with natural phytochemicals for lung cancer therapy: an in-silico study.
10 Feb 2026· Journal, genetic engineering & biotechnology· PUBMED
Publication
Therapeutic effects of IGF-2 on NMOSD by inhibiting astrocyte apoptosis through modulation of the IGF-1R/PI3K/AKT signaling pathway.
27 Jan 2026· Scientific reports· PUBMED
Publication
Styrylquinoline Derivatives as IGF1R Inhibitors.
16 Jan 2026· ACS medicinal chemistry letters· PUBMED