Target

IL-1

Interleukin-1

Also: IL-1beta, IL-1β, IL1β

10open trials
24trials in total
217publications
0researchers

Diseases

The last 24 months

New trials, publications, preprints and grants on this target, month by month.

TrialsPublicationsPreprintsGrants

Publication
Atorvastatin inhibits PASMC proliferation in pulmonary hypertension via the TLR4/NF-κB/NLRP3/IL-1β pathway.
6 Nov 2026· Journal of cardiovascular pharmacology· PUBMED
Trial
Anakinra Rescue Treatment for Moderate Asthma Attacks (ARTMA)
1 Nov 2026· PHASE1 · NOT_YET_RECRUITING· CTGOV
Publication
FOSL1-associated condensates modulate superenhancer-mediated selected IL-1 family gene activation in psoriasis.
28 Oct 2026· Science advances· PUBMED
Preprint
Inflammasome Activation and IL-1β Release in Alveolar Macrophages Infected with Pseudomonas aeruginosa is Reduced in Hypoxia.
28 Oct 2026· bioRxiv : the preprint server for biology· PUBMED
Publication
Adult-onset chronic nonbacterial osteitis mimicking refractory axial psoriatic arthritis: successful treatment with combined IL-1/IL-17 inhibition: a case report and brief literature review.
23 Oct 2026· EULAR rheumatology open· PUBMED
Publication
Mycobacterium smegmatis MSMEG_6906 modulates IL-1β via NF-κB pathway to benefit intracellular survival.
23 Oct 2026· Microbial pathogenesis· PUBMED
Trial
Enhancing ICB Efficacy Through IL-1 Inhibition in TNBC
20 Oct 2026· PHASE1_PHASE2 · RECRUITING· CTGOV
Publication
Long COVID shows IL-1 pathway dysregulation without a discrete circulating biomarker signature.
19 Oct 2026· Frontiers in immunology· PUBMED
Publication
Sulforaphane Attenuates Ulcerative Colitis by Activating Nrf2 and Suppressing the NLRP3/IL-1β Inflammasome Axis.
16 Oct 2026· Current molecular medicine· PUBMED
Publication
Reply to "Interpreting Hyperacute IL-1β and NET Signals in Large-Vessel Occlusion Stroke".
14 Oct 2026· Annals of neurology· PUBMED
Publication
A self-amplifying IL-1β-CCL2 circuit between macrophages and cancer-associated fibroblasts drives colorectal cancer progression.
14 Oct 2026· Cancer letters· PUBMED
Publication
Interpreting Hyperacute IL-1β and NET Signals in Large-Vessel Occlusion Stroke.
14 Oct 2026· Annals of neurology· PUBMED
Publication
Detection of Serum IL-1β and IL-10 as Biomarkers for Anti-Tuberculosis Drug Resistance.
1 Oct 2026· Clinical laboratory· PUBMED
Publication
Anti-Neuroinflammatory Effects of Cardenolides in IL-1β-Activated SK-N-SH Cells.
1 Oct 2026· Molecules (Basel, Switzerland)· PUBMED
Publication
High Postoperative-to-Preoperative IL-1β Ratio Links to Poor Survival in Colorectal Cancer.
1 Oct 2026· Journal of visualized experiments : JoVE· PUBMED
Trial
Tear Biomarkers for Migraine
30 Sept 2026· NA · NOT_YET_RECRUITING· CTGOV
Publication
Huwang Mingmu decoction protects retinal neurons in early diabetic retinopathy by suppressing the IL-1β-c-Jun-GS pathway: an in vivo and in vitro study.
18 Sept 2026· In vitro cellular & developmental biology. Animal· PUBMED
Publication
Therapeutic response to exclusive enteral nutrition correlates with suppressed IL-17 signaling activity and diminished IL-1β secretion in pediatric Crohn's disease.
14 Sept 2026· Frontiers in nutrition· PUBMED
Publication
IL-1β-driven SERPINE1 Upregulation is Associated with CAD-ICM-related Cardiomyocyte Remodeling.
11 Sept 2026· Current drug targets· PUBMED
Publication
IL1β Functions as a Tumor Suppressor in Papillary Thyroid Carcinoma via the SMDT1-MAPK Signaling Axis.
9 Sept 2026· Cancers· PUBMED
Publication
Defective IL-17 production is associated with reduced IL-1β levels in response to Mycobacterium tuberculosis in HIV+ children with latent tuberculosis infection.
9 Sept 2026· Frontiers in immunology· PUBMED
Publication
Nanomaterial-Based Strategies Targeting IL-1 Signalling in Inflammatory Bowel Disease: Therapeutic Applications and Mechanistic Insights.
7 Sept 2026· Journal of inflammation research· PUBMED
Publication
SDH inhibition quenches rheumatoid arthritis flare-associated IL-1β+IFN-γ+ macrophages via NF-κB/STAT4.
4 Sept 2026· Annals of the rheumatic diseases· PUBMED
Publication
Serum VIP and IL-1β Levels Are Associated With Anxiety and Depression in Patients With Parkinson's Disease: A Cross-Sectional Study.
1 Sept 2026· Brain and behavior· PUBMED
Publication
The myeloid IL-1 receptor limits IL-27-mediated endothelial type I IFN during nephrotoxic serum nephritis.
1 Sept 2026· JCI insight· PUBMED
Publication
Formononetin Attenuates Seizure Severity and Cognitive Deficits in PTZ-Kindled Rats with Associated Changes in Oxidative Stress and P2 X 7/IL-1β/Glutamate Signalling Markers.
27 Aug 2026· Neurochemical research· PUBMED
Publication
Discovery of four new coumarins from Zanthoxylum avicennae and transcriptomic elucidation of avicennol-mediated protection against NAFLD through CD36 and IL-1β regulation.
24 Aug 2026· Chinese herbal medicines· PUBMED
Publication
TNFα and endothelial IL-1 receptor signaling drive peritubular capillary regression and mature collagen accumulation in obstructive kidney injury.
21 Aug 2026· American journal of physiology. Renal physiology· PUBMED
Publication
Targeting the HIF-1α/IL-1β Axis in Macrophages With the Novel Inhibitor LJ-6 Mitigates Adipose Tissue Inflammation in Cellular and Ex Vivo Models.
21 Aug 2026· Frontiers in bioscience (Landmark edition)· PUBMED
Publication
Recurrent Sterile Pleuropericarditis After Withdrawal of Renal Transplant Immunosuppression in Anuric ESRD: A Case of Suspected IL-1-Mediated Autoinflammation.
20 Aug 2026· Case reports in rheumatology· PUBMED

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