New trials, publications, preprints and grants on this target, month by month.
Publication
Astragaloside IV ameliorates combined allergic rhinitis and asthma syndrome by inhibiting the activation of the STAT6/GATA3/IL-4 and PI3K/AKT/NF-κB signaling pathways.
29 Oct 2026· Naunyn-Schmiedeberg's archives of pharmacology· PUBMED
Publication
Mast Cell-Derived IL-4 Induces Pathogenic Cardiac Fibroblasts in Heart Failure.
5 Oct 2026· Circulation· PUBMED
Publication
Neonatal IL-4 and IL-5 signaling drives long-term inflammation after early-life allergen exposure in a mouse model of allergic sensitization.
2 Oct 2026· Frontiers in immunology· PUBMED
Publication
Evidence that IL-4/IL-13-Responsive IGFLs Promote Allergic Skin Inflammation.
30 Sept 2026· The Journal of investigative dermatology· PUBMED
Publication
House Dust Mite Induces Distinct Cellular and Extracellular Vesicle-Associated miRNA Signatures in BEAS-2B Cells: Targeted Analysis of IL-4 Responses.
24 Sept 2026· Cells· PUBMED
Publication
Response to "Route of IL-4 administration in Li et al.: an inconsistency between the methods and Section 4.4".
20 Sept 2026· Brain, behavior, and immunity· PUBMED
Publication
Efficacy of probiotics combined with tacrolimus ointment in children with atopic dermatitis and its effects on serum IgE, IL-4, and LTB4: A single-center retrospective cohort study.
18 Sept 2026· Medicine· PUBMED
Publication
Persistent Patch Test Reactivity to Compositae Mix and Sesquiterpene Lactone Mix During Anti-IL-4/IL-13 Therapy in Two Cases.
28 Aug 2026· Contact dermatitis· PUBMED
Trial
Dupilumab in Major Depressive Disorder
27 Aug 2026· PHASE2 · RECRUITING· CTGOV
Publication
High Frequency of Circulating IL-4R+SELL+ Naïve B Cells Is Associated with Functional Cure in Chronic Hepatitis B Patients Receiving Antiviral Treatment.
26 Aug 2026· Journal of clinical and translational hepatology· PUBMED
Publication
CGRP receptor antagonism impairs microglial anti-inflammatory function: IL-4 supplementation as a compensatory strategy for migraine.
25 Aug 2026· Brain, behavior, and immunity· PUBMED
Publication
Case Report: Effective IL-4/IL-13 axis suppression and resolution of severe atopic dermatitis by dupilumab monotherapy in a patient with IPEX syndrome.
17 Aug 2026· Frontiers in immunology· PUBMED
Publication
IL-4Rα antagonist (Stapokibart) in refractory palmoplantar pustulosis: a case report and literature review of Th2-targeted therapies.
13 Aug 2026· Frontiers in immunology· PUBMED
Publication
Nasal Lavage IL-4 and IL-13 in Cystic Fibrosis-Related Chronic Rhinosinusitis: Associations With Disease Severity and Potential Implications for Targeted Therapies.
13 Aug 2026· International forum of allergy & rhinology· PUBMED
Publication
Stapokibart (CM310) in Atopic Dermatitis: A Narrative Review of a Next-Generation IL-4Rα Antagonist.
31 Jul 2026· Dermatology practical & conceptual· PUBMED
Publication
[Mechanism study on electroacupuncture regulating IL-4/JAK1/STAT6 signaling pathway to promote M2 macrophage polarization and improve intestinal mucosal barrier injury in mice with ulcerative colitis].
25 Jul 2026· Zhen ci yan jiu = Acupuncture research· PUBMED
Publication
Comment on 'Should Paradoxical Psoriasis Trigger Rheumatological Surveillance During IL-4/IL-13 Blockade?'.
24 Jul 2026· Clinical and experimental dermatology· PUBMED
Publication
Monoclonal antibodies targeting IL-5/5R or IL-4/13 pathways in eosinophilic myocarditis: a single-centre experience and systematic literature review.
14 Jul 2026· European heart journal. Cardiovascular pharmacotherapy· PUBMED
Publication
The potential of targeted IL-4 therapy for the comorbidity of atopic dermatitis and attention-deficit/hyperactivity disorder in children via the skin-brain axis.
10 Jul 2026· Frontiers in allergy· PUBMED
Publication
Elevated IL-4 and IL-13 Expression in Hailey-Hailey Disease: Evidence for Th2-Mediated Pathogenesis and Targeted Treatment.
6 Jul 2026· Journal of cutaneous pathology· PUBMED
Publication
Indole-3-carbinol attenuates DNCB-induced atopic dermatitis in mice by reducing inflammation and IL-4/IL-13 expression.
2 Jul 2026· Biomolecules & biomedicine· PUBMED
Publication
Comment on: Bronchodilator response is linked with uncontrolled moderate-to-severe childhood asthma and elevated IL-4 and IL-13.
1 Jul 2026· Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology· PUBMED
Publication
A novel JAK1 mutation identified in a patient with severe atopic dermatitis phenotype: Mechanistic insights and IL-4Rα targeted therapy.
30 Jun 2026· Clinical immunology (Orlando, Fla.)· PUBMED
Publication
Efficacy and Safety of IL-4Rα and IL-5/IL-5R Targeted Biologic Therapies in Type 2 Inflammatory Airway Diseases: A Systematic Review and Meta-Analysis.
26 Jun 2026· Journal of clinical medicine· PUBMED
Publication
IL-4/IL-13-Driven Dysregulation of Epidermal Lipid Metabolism in Atopic Dermatitis: An Immunometabolic Link Between Type 2 Inflammation and Barrier Dysfunction.
22 Jun 2026· Cells· PUBMED
Publication
IL-4 in Alzheimer's Disease-Mechanisms and Therapeutic Potential.
20 Jun 2026· Molecular neurobiology· PUBMED
Publication
High-dimensional single-cell mass cytometry analysis of IL-4 treated human macrophages reveals heterogeneity and a CD206high anticolitic subset.
8 Jun 2026· Journal of leukocyte biology· PUBMED
Publication
Bronchodilator response is linked with uncontrolled moderate-to-severe childhood asthma and elevated IL-4 and IL-13.
1 Jun 2026· Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology· PUBMED
Publication
Dupilumab attenuate IL-4 and IL-13 synergistic effect on airway remodeling in asthma via blocking IL-4Rα/STAT6 axis.
30 May 2026· Scientific reports· PUBMED
Publication
Phase Ib/II Study of Preliminary Efficacy, Safety and Pharmacodynamics of MG-K10, a Humanised Monoclonal Antibody Targeting IL-4Rα, in Adult Chinese Patients With Asthma.
29 May 2026· Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology· PUBMED