New trials, publications, preprints and grants on this target, month by month.
Trial
Anti-Interleukin-6 (IL6) in Calciphylaxis
1 Sept 2027· PHASE1 · NOT_YET_RECRUITING· CTGOV
Publication
Comparative cardiovascular outcomes of IL-6 inhibitors versus rituximab in rheumatoid arthritis: a claims-based observational study.
5 Nov 2026· Clinical rheumatology· PUBMED
Publication
Inflammatory and immune checkpoint signatures in thyroid cancer: IHC profiling of IL-6 and its inducer PDL1 distinguishes histopathological subtypes and reflects tumor aggressiveness.
1 Nov 2026· Journal of immunoassay & immunochemistry· PUBMED
Publication
S100A9 Induces RANKL Expression in Osteocytes Utilizing IL-6/sIL-6R Combination and gp130 Signaling Pathways.
31 Oct 2026· FASEB journal : official publication of the Federation of American Societies for Experimental Biology· PUBMED
Publication
Vertical Sleeve Gastrectomy inhibits 11βHSD1 and subsequently reduces IL6 secretion in Mice and Humans: A Shared Anti-Inflammatory Mechanism.
29 Oct 2026· The Journal of endocrinology· PUBMED
Publication
PM2.5 exposure associates with IL-6 gene hypomethylation and systemic IL-6 expression in an at-risk asthma cohort.
27 Oct 2026· The Journal of allergy and clinical immunology· PUBMED
Publication
Erratum: CSNK2A1-mediated MAX phosphorylation upregulates HMGB1 and IL-6 expression in cholangiocarcinoma progression.
23 Oct 2026· Hepatology communications· PUBMED
Publication
Inflammatory biomarkers (IL-6, IL-10, IL-17, TNF-α) in TB patients attending a tertiary care hospital in Bhubaneswar, Odisha: a cross - sectional study.
21 Oct 2026· Indian journal of medical microbiology· PUBMED
Publication
Fibroblast-like synoviocytes exacerbate autoimmune arthritis upon psychological stress in an IL-6-dependent manner.
16 Oct 2026· Science advances· PUBMED
Publication
Upregulated ST2L-Dependent IL-33 Signaling in Dermal Fibroblasts Contributes to IL-6 Induction and Skin Fibrosis in Systemic Sclerosis.
13 Oct 2026· The Journal of dermatology· PUBMED
Publication
CD147+ Cancer-Associated Fibroblasts Promote PD-L1 Expression in Hepatocellular Carcinoma via TIMP2/MMP2/IL-6 Signaling.
12 Oct 2026· Asia-Pacific journal of clinical oncology· PUBMED
Publication
Beyond BCLC and AFP: A Circulating IL-6/IL-8 Inflammatory Signature Refines Survival Prediction in Hepatocellular Carcinoma.
12 Oct 2026· Immunology· PUBMED
Publication
Integrative transcriptomic and molecular dynamics simulations analysis identifies IL6 as a therapeutic hub gene in inflammatory arthritis.
9 Oct 2026· Computational biology and chemistry· PUBMED
Publication
Association analysis of IL-6 polymorphisms and relevant biomarkers in patients with renal failure.
9 Oct 2026· Biomedical reports· PUBMED
Trial
Multimodal Assessment of NMES Effects on Respiratory and Peripheral Muscles in COPD
1 Oct 2026· NA · RECRUITING· CTGOV
Trial
GAS5 Gene Expression and IL-6 in Rheumatoid Arthritis
1 Oct 2026· NA · NOT_YET_RECRUITING· CTGOV
Trial
Salivary IL-8 and Serum IL-6 as Biomarkers for Oral Potentially Malignant Disorders in Smokers and Never-Smokers
1 Oct 2026· NA · RECRUITING· CTGOV
Publication
A Point-of-Care High-Throughput Biosensing System of Home Monitoring for CRC Postoperative Recurrence by Detecting CEA, MicroRNA-21, and IL-6.
1 Oct 2026· IEEE transactions on bio-medical engineering· PUBMED
Publication
Histopathological and Bioinformatic Analysis of the IL-6/STAT3 Signaling Pathway in Ovarian Neoplasms.
1 Oct 2026· Pakistan journal of biological sciences : PJBS· PUBMED
Publication
Cancer-associated fibroblasts drive papillary thyroid cancer progression through ROS/NF-κB/IL-6 signaling in hypoxic microenvironments.
1 Oct 2026· Endocrine-related cancer· PUBMED
Publication
Repurposing FDA approved drugs targeting IL-6 associated signalling for the management of rheumatoid arthritis: an in silico and experimental approach.
1 Oct 2026· Naunyn-Schmiedeberg's archives of pharmacology· PUBMED
Publication
Integrated network toxicology and multiomics analyses reveal the mechanisms underlying trimethyltin chloride-induced epilepsy and the ameliorative effects of astaxanthin via NFKB1 and IL6.
29 Sept 2026· Ecotoxicology and environmental safety· PUBMED
Publication
Lipotoxicity Amplifies IL-6 Trans-Signaling in Sinusoidal Endothelial Cells to Promote Endotheliopathy and Liver Injury.
28 Sept 2026· Journal of gastroenterology and hepatology· PUBMED
Publication
HCorrelation of serum IL-6 and SMAD3 levels with neurological impairment and their combined functional outcome value in acute intracerebral hemorrhage.
25 Sept 2026· Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia· PUBMED
Publication
Inhibition of CDK9 improves colonic epithelial dysfunction in DSS-induced ulcerative colitis mice by blocking the IL-6/STAT3 signaling pathway.
22 Sept 2026· Molecular immunology· PUBMED
Publication
Gut microbiota regulation of the IL-6/STAT3 pathway: Linking hematopoiesis to colorectal cancer progression.
21 Sept 2026· International immunopharmacology· PUBMED
Publication
Potential links between gut microbiota-derived propionate and succinate and CXCL8, IL1B, and IL6 in NMOSD: An integrated network pharmacology and mendelian randomization study.
18 Sept 2026· Journal of neuroimmunology· PUBMED
Publication
Association of TNF-α, TGF-β1, IFN-γ, IL-6, and IL-10 Gene Polymorphisms with Hodgkin Lymphoma: Susceptibility and Clinical Outcomes.
17 Sept 2026· Journal of clinical medicine· PUBMED
Publication
Cathelicidin LL-37 inhibits angiogenesis and migration in gastric cancer via inhibition of NF-κB/IL-6 signaling.
16 Sept 2026· Histology and histopathology· PUBMED
Publication
Diosgenin suppresses colorectal cancer cell malignancy by modulating the AKT1/IL-6/STAT3 signaling axis.
15 Sept 2026· American journal of translational research· PUBMED