New trials, publications, preprints and grants on this target, month by month.
Publication
ALDH2 Suppresses Ferroptosis and Promotes Bortezomib Resistance in Multiple Myeloma Through the KEAP1-NRF2 Feedback Loop.
28 Oct 2026· Advanced science (Weinheim, Baden-Wurttemberg, Germany)· PUBMED
Publication
NRF2-KEAP1 signaling in chromium-induced lung carcinogenesis: mechanistic insights and evidence gaps.
22 Oct 2026· Toxicology mechanisms and methods· PUBMED
Publication
Selective NRF2 target induction despite falling NFE2L2 transcription across the MASLD spectrum: implications for marginal donor grafts and KEAP1-targeted therapy.
20 Oct 2026· Free radical biology & medicine· PUBMED
Publication
Tumor-educated macrophages promote ferroptosis inhibition in pancreatic cancer via activating the p62-KEAP1-NRF2 pathway.
12 Oct 2026· Frontiers in immunology· PUBMED
Publication
Variant-informed multimodal tissue-state modeling reveals an NRF2 stress niche and dependency axis in KEAP1/NFE2L2-altered cancer.
6 Oct 2026· Frontiers in immunology· PUBMED
Publication
Dapagliflozin attenuates cardiomyocyte hypertrophy by inhibiting KEAP1-NRF2-mediated ferroptosis pathway.
1 Oct 2026· The Journal of pharmacy and pharmacology· PUBMED
Publication
FTO mediates benzo[a]pyrene-induced lung cancer progression through regulating ferroptosis via lactylation-driven YTHDF2-KEAP1-NRF2 axis.
29 Sept 2026· Journal of hazardous materials· PUBMED
Publication
Subtype-Conditioned NRF2-KEAP1 Signaling in Breast Cancer: A Narrative Review and Hypothesis-Generating Framework from Chemoprevention to Therapy Resistance.
22 Sept 2026· Antioxidants (Basel, Switzerland)· PUBMED
Publication
Environmental Exposure to Triclosan Promotes Rheumatoid Arthritis via KEAP1/NRF2 Inhibition and Subsequent IL-17 Signaling Activation.
22 Sept 2026· Environmental science & technology· PUBMED
Publication
KEAP1 loss-of-function suppresses immunogenic ferroptosis and limits PD-1 blockade efficacy through an NRF2-FSP1 pathway.
17 Sept 2026· Cancer letters· PUBMED
Publication
The deubiquitinase YOD1 in renal tubular epithelial cells promotes diabetic kidney disease by stabilizing KEAP1.
14 Sept 2026· Acta pharmacologica Sinica· PUBMED
Publication
Betulin supplementation reduces oxidative stress in Alzheimer's disease via the activation of KEAP1/NRF2 pathway.
10 Sept 2026· The Journal of nutritional biochemistry· PUBMED
Publication
In situ transformable fibrillar networks ameliorate secondary brain injury after intracerebral hemorrhage by activating KEAP1-Nrf2/ARE axis.
10 Sept 2026· Biomaterials· PUBMED
Publication
The Discovery of GSK3227634: A Potent Inhaled Inhibitor of the KEAP1/NRF2 Protein-Protein Interaction for the Treatment of Chronic Obstructive Pulmonary Disease.
10 Sept 2026· Journal of medicinal chemistry· PUBMED
Publication
The KEAP1-NFE2L2/NRF2 Axis in Non-Small Cell Lung Cancer Radioresistance: Redox Homeostasis and Emerging DNA Damage Response Mechanisms.
3 Sept 2026· Cancer management and research· PUBMED
Publication
Metformin Enhances Antioxidant Defenses and Limits Lipid Peroxidation Through the Modulation of Nrf2/KEAP1 Pathway in Hippocampal Neurons Exposed to Amyloid-β Oligomers.
13 Aug 2026· Neurotoxicity research· PUBMED
Publication
ACOD1 enhances the ferroptosis resistance of tumor-associated macrophages through the KEAP1/NRF2 axis and promotes triple-negative breast cancer progression.
12 Aug 2026· Pathology, research and practice· PUBMED
Publication
Case Report: DICER1-mutant primary intracranial sarcoma with concurrent TP53, PDGFRA, and KEAP1 somatic mutations in a 5.5-year-old boy.
30 Jul 2026· Frontiers in oncology· PUBMED
Publication
SMARCA4, STK11, and KEAP1 co-inactivation associates with poor prognosis and upregulation of the TGF-β pathway in lung adenocarcinoma.
20 Jul 2026· Translational oncology· PUBMED
Publication
Hudi enteric-coated capsule and its active constituent polydatin suppress Th1/Th17-mediated intestinal inflammation by modulating the KEAP1-NFE2L2 signaling pathway.
3 Jul 2026· Precision clinical medicine· PUBMED
Publication
Clinical Outcomes Associated with Single STK11 Mutations and Those Co-occurring with KEAP1 and KRAS Mutations in Metastatic Non-Small Cell Lung Cancer.
30 Jun 2026· Advances in therapy· PUBMED
Publication
Beyond KEAP1: The Context-Specific NRF2 Partner Code in Disease and Therapy.
16 Jun 2026· Antioxidants (Basel, Switzerland)· PUBMED
Publication
Regulation of the KEAP1/NRF2 pathway by claudin-2-targeted lymphoid enhancer-binding factor 1 binding in gastric cancer progression.
10 Jun 2026· Journal of physiology and pharmacology : an official journal of the Polish Physiological Society· PUBMED
Preprint
SMARCA4, STK11, and KEAP1 co-inactivation associates with poor prognosis and upregulation of the TGF-β pathway in lung adenocarcinoma.
8 Jun 2026· bioRxiv : the preprint server for biology· PUBMED
Publication
CUL7-mediated KEAP1 ubiquitination promotes the progression of colon cancer via NRF2 signaling.
8 Jun 2026· Cell death & disease· PUBMED
Publication
KEAP1 promoter hypermethylation in human cancers: a meta-analysis of case-control studies.
6 Jun 2026· International journal of clinical oncology· PUBMED
Publication
TSC22D4 drives clear cell renal cell carcinoma progression and therapy resistance by stabilizing NRF2 through KEAP1 disruption.
5 Jun 2026· Cell death & disease· PUBMED
Publication
PEBP4 alleviates muscle wasting in lung cancer cachexia via KEAP1-NRF2-mediated redox homeostasis.
3 Jun 2026· Cell death & disease· PUBMED
Publication
Corrigendum to "KRAS G12C inhibitor outcomes in advanced non-small cell lung cancer by smoking history, performance status, and KEAP1 mutation status" [Cancer Treatment and Research Communications 47 (2026) 101227].
16 May 2026· Cancer treatment and research communications· PUBMED
Publication
KEAP1-mediated mitochondrial remodeling on stiffness-graded collagen substrates drives hepatocellular carcinoma adaptation.
12 May 2026· Biomaterials· PUBMED