Target

KIT

Mast/stem cell growth factor receptor

Also: c-KIT, c-Kit

8open trials
16trials in total
52publications
0researchers

Diseases

The last 24 months

New trials, publications, preprints and grants on this target, month by month.

TrialsPublicationsPreprintsGrants

Trial
Hepzato Kit and Opdualag for Metastatic Melanoma and Liver Metastasis
1 Nov 2026· PHASE1_PHASE2 · RECRUITING· CTGOV
Publication
Beyond the Favorable-Risk Label: Sequential Measurable Residual Disease and KIT Variant Status in Pediatric Core-Binding Factor Acute Myeloid Leukemia.
12 Oct 2026· Annals of laboratory medicine· PUBMED
Publication
Selective KIT inhibition supports mast cells as key drivers of allergic asthma pathogenesis.
26 Sept 2026· The Journal of allergy and clinical immunology· PUBMED
Publication
Gastric Cancer-Derived Exosomes Activate Mast Cells via the SCF/c-KIT Pathway to Drive Angiogenesis and Metastasis.
14 Sept 2026· Oncology research· PUBMED
Publication
KIT mutation and AHN-associated oncogenic profiles in systemic mastocytosis with an associated hematological neoplasm.
8 Sept 2026· Blood advances· PUBMED
Publication
RETRACTED: Aburjania et al. Synthetic Makaluvamine Analogs Decrease c-Kit Expression and Are Cytotoxic to Neuroendocrine Tumor Cells. Molecules 2020, 25, 4940.
20 Aug 2026· Molecules (Basel, Switzerland)· PUBMED
Publication
Prognostic Impact of Sequential Measurable Residual Disease and KIT Variant Status in Pediatric Core-Binding Factor Acute Myeloid Leukemia: A Retrospective Multicenter Study of the Taiwan Pediatric Oncology Group.
19 Aug 2026· Annals of laboratory medicine· PUBMED
Publication
SuperRCA assay of KIT p.D816V mutation load reveals novel correlation to clinical phenotype.
18 Aug 2026· The journal of allergy and clinical immunology. Global· PUBMED
Publication
Imatinib: A Multifunctional Tyrosine Kinase Inhibitor with Diverse Mechanisms Targeting BCR-ABL, c-KIT, and PDGFR in Cancer Therapy.
31 Jul 2026· Current pharmaceutical design· PUBMED
Publication
The role of KIT mutations in oral melanoma and disease progression: A literature review on early detection and targeted therapy.
30 Jul 2026· Mutation research· PUBMED
Publication
Advanced Metastatic Melanoma With C-KIT (CD117) Immunohistochemical Expression: A Case Report and Therapeutic Considerations.
21 Jul 2026· Cureus· PUBMED
Publication
Distinct Temporal Modulation of Mesenchymal Stem Cells and Empagliflozin on Renal c-Kit Cells in Diabetic Kidney Disease.
20 Jul 2026· Frontiers in bioscience (Landmark edition)· PUBMED
Publication
Molecular study of KIT gene that is related to drug resistance in chronic myeloid leukemia patients.
20 Jul 2026· Journal, genetic engineering & biotechnology· PUBMED
Publication
Activation of KIT signaling promotes early tumorigenesis through the AP-1 pathway in APC/TP53 double-knockout human colon organoids.
4 Jul 2026· Cell death & disease· PUBMED
Publication
Molecular Mechanisms of KIT Receptor Dimerization and Oncogenic Activation Revealed by Multiscale Simulations.
30 Jun 2026· Journal of chemical information and modeling· PUBMED
Publication
Unresponsive Systemic Mastocytosis in a Young AML With RUNX1::RUNX1T1 Fusion With Rare KIT c.1255_1257delGAC Mutation: A Clinical Deadlock.
26 Jun 2026· Journal of pediatric hematology/oncology· PUBMED
Publication
Radiographic Versus Pathology-Integrated Response for Assessing Optimal Surgical Timing After Neoadjuvant Imatinib in Patients With Locally Advanced KIT Exon 11-Mutant GIST.
26 Jun 2026· Annals of surgery· PUBMED
Publication
KIT Mutations Are More Common in Mucosal than Acral Melanoma: A Case-Series of 152 Patients from a Single Centre.
24 Jun 2026· Biomedicines· PUBMED
Publication
Role of SCF/c-KIT axis in pericyte TNT-guided vessel branching.
16 Jun 2026· Fluids and barriers of the CNS· PUBMED
Publication
Clinical profiling of AML1::ETO and KIT exon 17 mutation in pediatric AML by high-throughput drug sensitivity.
15 Jun 2026· BMC cancer· PUBMED
Publication
KIT and FLT3-ITD mutations do not predict outcomes in pediatric core-binding factor acute myeloid leukemia: findings from the C-HUANAN-AML-15 multicenter cohort study.
10 Jun 2026· Annals of hematology· PUBMED
Publication
A diagnostic signature derived from NK cell related genes in prostate cancer: insights from integrated scRNA-seq and bulk RNA-seq analyses with functional validation of KIT.
3 Jun 2026· Frontiers in immunology· PUBMED
Publication
Endothelial soluble APP/APLP2 promote heart repair through KIT-mediated angiogenesis.
22 May 2026· Science advances· PUBMED
Publication
A phosphorylated variant of the mast/stem cell growth factor receptor KIT is upregulated in dorsal root ganglia of Friedreich ataxia.
20 May 2026· Histology and histopathology· PUBMED
Publication
Unmasking the "targetless" illusion: branched clonal evolution of TERT and KIT in acral melanoma revealed by sequential multi-site biopsies- a case report.
20 May 2026· Frontiers in immunology· PUBMED
Publication
KIT-dependent acute myeloid leukemias are responsive to LSD1 inhibition.
14 May 2026· Clinical epigenetics· PUBMED
Publication
Correction: miR-1260b, mediated by YY1, activates KIT signaling by targeting SOCS6 to regulate cell proliferation and apoptosis in NSCLC.
11 May 2026· Cell death & disease· PUBMED
Publication
TRNP1 regulates tumorigenesis and enhances immunotherapy response via c-Kit/STAT3 signaling in hepatocellular carcinoma.
28 Apr 2026· Journal of gastrointestinal oncology· PUBMED
Publication
Myeloid neoplasms with mutated KIT: comparative clinicopathologic analysis of D816 vs. non-D816 variants.
28 Apr 2026· Cancer genetics· PUBMED
Publication
Changes in Circulating Biomarkers in Patients With Ischemic Heart Failure After Treatment With Autologous Mesenchymal Stromal Cells and c-Kit-Positive Cardiac Cells, Alone or in Combination: Results From the Cardiovascular Cell Therapy Research Network CONCERT-HF Clinical Trial.
20 Apr 2026· Journal of the American Heart Association· PUBMED

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