Target

LRRK2

Leucine-rich repeat serine/threonine-protein kinase 2

7open trials
12trials in total
148publications
0researchers

Diseases

Parkinson disease12 trials
Gaucher disease1 trial

The last 24 months

New trials, publications, preprints and grants on this target, month by month.

TrialsPublicationsPreprintsGrants

Publication
PIKfyve inhibition induces LRRK2 activation through phosphatidylinositol 3-phosphate and CASM.
6 Nov 2026· Life science alliance· PUBMED
Publication
ClC-7 links PIKfyve inhibition to Rab-dependent LRRK2 activity at lysosomes.
20 Oct 2026· The Journal of cell biology· PUBMED
Publication
Generation of a CRISPR/Cas9-corrected isogenic control iPSC line (NIMHi001-A-1) from a Parkinson's disease Patient-Derived iPSC line carrying the LRRK2 I1371V mutation.
9 Oct 2026· Stem cell research· PUBMED
Publication
Single-Nucleus Phosphatome Rewiring and Phosphoproteomics Reveal PFKFB2 as an LRRK2-Linked Metabolic Node in Human Parkinsonian Substantia Nigra.
7 Oct 2026· ACS omega· PUBMED
Publication
Development and pre-qualification of a facile and ultra-sensitive LRRK2 LC/MS assay using high-affinity unmodified immobilization for immunocapture: meet bioanalytical challenges and search practical solutions.
7 Oct 2026· Bioanalysis· PUBMED
Publication
PPM1H loss alters intrasynaptic alpha-synuclein localization in a LRRK2-dependent manner.
29 Sept 2026· Molecular brain· PUBMED
Publication
α-Synuclein Seeding Discriminates Between LRRK2 G2019S Variant Carriers with and Without Parkinson's Disease.
28 Sept 2026· Movement disorders : official journal of the Movement Disorder Society· PUBMED
Publication
Comparative study of Parkinson's disease phenotypes in homozygous and heterozygous LRRK2-G2019S mutation carriers.
27 Sept 2026· Acta neurologica Belgica· PUBMED
Publication
Design and development of novel, potent and brain penetrant cyclic LRRK2 inhibitors for the treatment of Parkinson's disease.
23 Sept 2026· European journal of medicinal chemistry· PUBMED
Publication
Colonic LRRK2 expression is increased in Crohn's disease but not in Parkinson's disease and idiopathic RBD.
19 Sept 2026· Acta neuropathologica· PUBMED
Publication
Disrupted TFEB/GDNF-cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice.
16 Sept 2026· Advanced science (Weinheim, Baden-Wurttemberg, Germany)· PUBMED
Publication
Association between cerebrospinal fluid LRRK2 and incident orthostatic hypotension differs by genetic background in Parkinson's disease.
14 Sept 2026· Acta neurologica Belgica· PUBMED
Publication
Parkinson's disease-associated LRRK2 risk variant, G2385R, enhances Rab substrate phosphorylation and impairs neuronal integrity.
11 Sept 2026· Human molecular genetics· PUBMED
Preprint
Chemical Genetic Targeting of the LRRK2 GTPase Domain.
7 Sept 2026· bioRxiv : the preprint server for biology· PUBMED
Publication
Protocol to quantify LRRK2-mediated Rab10 phosphorylation using high-content imaging.
4 Sept 2026· STAR protocols· PUBMED
Publication
High frequency of LRRK2 p.Gly2019Ser in Moroccan Parkinson's disease: RFLP as a reliable genotyping approach.
2 Sept 2026· Neurogenetics· PUBMED
Trial
LRRK2 (Leucine-Rich Repeat Kinase 2) Parkinson's Disease Fingerprint
1 Sept 2026· NA · NOT_YET_RECRUITING· CTGOV
Publication
The Effect of LRRK2 and GBA1 Mutations on Survival in Early- and Late-Onset Parkinson's Disease.
1 Sept 2026· Movement disorders : official journal of the Movement Disorder Society· PUBMED
Publication
Neuroinflammatory and Motor Alterations in LRRK2*G2019S Transgenic Mice Without Enhanced Vulnerability to Aging or Chronic MPTP-Induced Nigrostriatal Neurodegeneration.
1 Sept 2026· Journal of neurochemistry· PUBMED
Preprint
The LRRK2 R1441G+M1646T haplotype is associated with slower motor symptom progression in Parkinson's disease.
31 Aug 2026· medRxiv : the preprint server for health sciences· PUBMED
Publication
LRRK2: Molecular Mechanisms in Parkinson's Disease.
25 Aug 2026· International journal of molecular sciences· PUBMED
Publication
Subtype-specific secretion of extracellular vesicles by LRRK2 and Rab GTPases under lysosomal stress.
13 Aug 2026· iScience· PUBMED
Publication
Up-regulation of the kinase LRRK2, in enteric glia contributes to mucosal barrier impairment in Parkinson's disease via secretory autophagy.
13 Aug 2026· British journal of pharmacology· PUBMED
Preprint
Gut bacterial Infection drives Parkinsonian pathology in LRRK2 G2019S Knock-in Mice.
11 Aug 2026· bioRxiv : the preprint server for biology· PUBMED
Publication
The structural basis for LRRK2's activation and autoinhibition.
10 Aug 2026· Cell· PUBMED
Publication
LRRK2 G2019S variant is associated with transcriptional changes in Parkinson's disease human myeloid cells under proinflammatory environment.
8 Aug 2026· Journal of neuroinflammation· PUBMED
Publication
LRRK2 regulates synaptic function through modulation of actin cytoskeletal dynamics.
6 Aug 2026· eLife· PUBMED
Publication
G2019S LRRK2 Kinase Inhibition in Heterozygous Mice Avoids Lung Phenotype Observed with Inhibition of WT LRRK2.
5 Aug 2026· ACS chemical neuroscience· PUBMED
Publication
At the Crossroads of Synapses and Signaling: The Role of LRRK2 in Neuronal Communication.
29 Jul 2026· Cellular and molecular neurobiology· PUBMED
Publication
LRRK2 G2019S reprograms innate and adaptive immunity to drive context-dependent host defense outcomes.
29 Jul 2026· Frontiers in cellular neuroscience· PUBMED

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