New trials, publications, preprints and grants on this target, month by month.
Trial
Study of Tovorafenib in High-Grade Glioma and Diffuse Intrinsic Pontine Glioma (DIPG)
1 Feb 2027· PHASE2 · NOT_YET_RECRUITING· CTGOV
Trial
Mirdametinib to Reduce the Size of Large/Giant Congenital Melanocytic Nevi in Children, Adolescents and Young Adults
4 Jan 2027· PHASE2 · NOT_YET_RECRUITING· CTGOV
Publication
Britanin improved high-fat diet-induced obesity by regulating the MAPK signaling pathway.
1 Dec 2026· Pakistan journal of pharmaceutical sciences· PUBMED
Publication
Combined casein kinase II and MAPK signalling inhibition as a therapeutic strategy for metastatic colorectal cancer.
5 Nov 2026· Experimental hematology & oncology· PUBMED
Publication
Early-life cigarette smoke exposure predisposes to COPD by suppressing the HAS2-TGF-B1-MAPK axis in lung fibroblasts.
3 Nov 2026· Ecotoxicology and environmental safety· PUBMED
Publication
Mechanism Investigation of Platycodon grandiflorum Active Ingredients in Regulating Epithelial-Mesenchymal Transition and Airway Remodeling in Asthma via Modulation of the Sirt6/RORγt/IL-17A Axis and IL-17A/MAPK Pathway.
3 Nov 2026· Journal of ethnopharmacology· PUBMED
Publication
JAK1/2 inhibition promotes aggressive cutaneous carcinogenesis through COT kinase-mediated alternative MAPK pathway activation.
2 Nov 2026· The Journal of clinical investigation· PUBMED
Publication
TNFAIP1 Facilitates the Progression of Diabetic Cardiomyopathy Through the p38 MAPK-Mediated ER Stress-Apoptosis Axis.
31 Oct 2026· FASEB journal : official publication of the Federation of American Societies for Experimental Biology· PUBMED
Publication
Ginsenoside Rg6 ameliorates COPD by targeting RAGE to suppress MAPK/NF-κB signaling, thereby preserving alveolar barrier integrity and attenuating EMT.
29 Oct 2026· Phytomedicine : international journal of phytotherapy and phytopharmacology· PUBMED
Publication
Dihydrocaffeic acid alleviates APOE4-associated astrocyte dysfunction and cognitive impairment via LRP1/p38 MAPK signaling.
28 Oct 2026· Journal of ethnopharmacology· PUBMED
Publication
GOLM1 interacts with EGFR and contributes to increased intestinal permeability in ulcerative colitis through p38 MAPK signaling.
28 Oct 2026· Cellular signalling· PUBMED
Publication
Hydroxytyrosol Attenuates Reserpine-Induced Parkinsonism and Hippocampal Damage by Downregulating Pro-inflammatory MAPK/AP-1-Related Gene Expression.
26 Oct 2026· Neurochemical research· PUBMED
Publication
Essential oil from Angelica sinensis Radix attenuates ischemic stroke via the cGMP/PKG/MAPK pathway: insights from network pharmacology and molecular mechanism evaluation.
23 Oct 2026· Journal of ethnopharmacology· PUBMED
Publication
TRIM27 enhances NF-κB/MAPK activation by ubiquitinating and degrading TRAF3 to drive asthma-induced airway inflammation.
23 Oct 2026· Molecular biology reports· PUBMED
Publication
Beyond BRAF V600: emerging MAPK-targeted therapeutic strategies.
23 Oct 2026· Annals of translational medicine· PUBMED
Publication
Inhibition of Bone Morphogenetic Protein 2 Suppresses the Stemness Maintenance of Cancer Stem Cells in Hepatocellular Carcinoma via the MAPK/ERK Pathway [Retraction].
21 Oct 2026· Cancer management and research· PUBMED
Publication
Hesperidin-mediated selenium nanoparticles protect against diabetic cisplatin-induced testicular injury via modulation of Nrf2/Keap1, TLR4/NF-κB/MAPK, and PERK/CHOP Signaling.
19 Oct 2026· Tissue & cell· PUBMED
Publication
Formononetin Protects Osteoblasts Against Oxidative Stress and Attenuates Ovariectomy-Induced Bone Loss in Association with MAPK/AP-1 and NRF2 Signaling.
19 Oct 2026· Antioxidants (Basel, Switzerland)· PUBMED
Publication
From MAPK Reactivation to Response: Clinical Approaches Targeting BRAF/MEK Resistance in Melanoma.
17 Oct 2026· American journal of clinical dermatology· PUBMED
Publication
Ginkgolide B Inhibits Colorectal Cancer Growth via Regulation of the PI3K/AKT/MAPK Pathways: A Comprehensive Analysis Using Network Pharmacology, Molecular Docking, and Verification in Cellular and Animal Models.
16 Oct 2026· Frontiers in bioscience (Landmark edition)· PUBMED
Publication
Aqueous extract of erigeron annuus ameliorates OVA-induced atopic dermatitis-like skin lesions through modulation of Th2-mediated immune responses and MAPK signaling.
16 Oct 2026· Pharmaceutical biology· PUBMED
Publication
Comutation of asxl1 and IDH2R172K enhances leukemogenesis and correlates with epigenetic activation of MAPK and AP-1 in zebrafish.
13 Oct 2026· Blood advances· PUBMED
Publication
Focused Ultrasound-Enhanced Delivery of ED5, a CK1α-Targeting Oleanolic Acid Analogue, Suppresses Glioma Growth via MAPK-ROS-ERS Pathway Modulation.
12 Oct 2026· Cancer biotherapy & radiopharmaceuticals· PUBMED
Publication
Gpr84 activation induces anti-mycobacterial defense in macrophages via MAPK signaling.
10 Oct 2026· Immunobiology· PUBMED
Publication
Inhibition of G6PD-Mediated MAPK Signaling Triggers Mitochondrial Apoptosis and Cell Cycle Arrest in Hepatocellular Carcinoma.
10 Oct 2026· Frontiers in bioscience (Landmark edition)· PUBMED
Publication
Expression of V‑domain Ig suppressor of T cell activation in ovarian cancer and its regulation of follicular regulatory T‑cell function via the AKT/MAPK pathway.
9 Oct 2026· Oncology reports· PUBMED
Publication
Ent-7β-hydroxy-15-oxokaur-16-en-18-yl acetate suppresses RANKL-induced and LPS-enhanced osteoclastogenesis through NF-κB/MAPK signaling with involvement of the ACE-AT1R axis.
9 Oct 2026· International immunopharmacology· PUBMED
Publication
The circMTCL1/miR-145-5p/BMP3 axis suppresses colorectal cancer cell growth by mediating the MAPK signaling pathway.
8 Oct 2026· Medical oncology (Northwood, London, England)· PUBMED
Publication
The Cx43/p38 MAPK/Runx2 signaling pathway as a potential regulatory axis in insufficient osteogenesis associated with osteoporosis.
8 Oct 2026· Frontiers in endocrinology· PUBMED
Publication
Natural (+)-camphor alleviates migraine induced by reserpine with local cerebral vasospasm via inhibiting p38β MAPK/ATF2 pathway.
8 Oct 2026· Journal of ethnopharmacology· PUBMED