New trials, publications, preprints and grants on this target, month by month.
Publication
Distinct tau PET dynamics in early versus late age-of-onset Alzheimer's disease.
4 Nov 2026· Science translational medicine· PUBMED
Publication
Integrated manufacturing platform for cortical organoids reveals early phosphatase and prefoldin dysregulation in MAPT V337M neurons.
3 Nov 2026· NPJ dementia· PUBMED
Publication
SSH1 knockdown increases autophagosome formation through ATG9A recruitment and promotes MAPT/tau protein degradation.
2 Nov 2026· Autophagy· PUBMED
Publication
Peripheral α-Synuclein oligomer accumulation in MAPT p.D750V-associated autosomal-dominant parkinsonism: evidence from in vivo skin biopsies.
31 Oct 2026· Journal of neural transmission (Vienna, Austria : 1996)· PUBMED
Publication
Cerebrospinal fluid p62/SQSTM1 is associated with tau pathology, brain structural alterations, and cognitive impairment in adults without dementia.
30 Oct 2026· Journal of Alzheimer's disease : JAD· PUBMED
Preprint
The human circular Tau 12->7 RNA is translated in mouse neurons and promotes tau aggregation.
30 Oct 2026· bioRxiv : the preprint server for biology· PUBMED
Preprint
Second-generation tau PET tracer in situ binding assessed with fluorescence imaging.
27 Oct 2026· Research square· PUBMED
Trial
A Study to Evaluate the Safety, Tolerability and Pharmacodynamics of NIO752 in Primary Tauopathies
23 Oct 2026· PHASE2 · NOT_YET_RECRUITING· CTGOV
Publication
The use of three murine genetic models of Alzheimer's disease reveals efficacy of 4',5,7-trihydroxyisoflavone in alleviating cognitive deficits and reducing levels of amyloid-beta and hyperphosphorylated tau protein.
22 Oct 2026· Laboratory animal research· PUBMED
Publication
BCG vaccination mitigates tau pathology and restores cognitive function in PS19 mice.
21 Oct 2026· Science advances· PUBMED
Publication
A sandwich ECL immunoassay system for tau protein detection using Ru(II)-AuNP signal probes integrated with copper nanoclusters.
15 Oct 2026· Analytical methods : advancing methods and applications· PUBMED
Publication
HuR modulates disease-relevant alternative splicing of MAPT and other Alzheimer's disease-related genes.
15 Oct 2026· Molecular genetics and genomics : MGG· PUBMED
Publication
Early cerebral hypoperfusion promotes spatially biased tau pathology in tau-seeded PS19 mice.
14 Oct 2026· GeroScience· PUBMED
Publication
Perfusion imaging predicts therapeutic cooling response and tracks cis-p-tau pathology in porcine brain injuries.
8 Oct 2026· Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics· PUBMED
Publication
The immunoproteasome in Alzheimer's disease: a dual regulator of tau pathology and microglial senescence.
3 Oct 2026· Inflammopharmacology· PUBMED
Publication
Effects of West Nile Virus on behavioral and cognitive performance, circadian body temperatures, cortical Aβ and p-tau pathology, and immune measures in human apoE and human amyloid precursor protein NL-G-F/human apoE mice.
2 Oct 2026· Frontiers in immunology· PUBMED
Publication
A murine model of amyloid enhanced tauopathy: progressive changes in tau pathology and behavior.
1 Oct 2026· Alzheimer's & dementia : the journal of the Alzheimer's Association· PUBMED
Publication
Pathway-specific polygenic risk scores modify the association between amyloid and tau PET accumulation in patients with Alzheimer's disease.
1 Oct 2026· Alzheimer's & dementia : the journal of the Alzheimer's Association· PUBMED
Publication
Sphingolipid and ceramide associations with tau pathology vary across diverse ethnoracial groups in postmortem brain tissue.
1 Oct 2026· Alzheimer's & dementia : the journal of the Alzheimer's Association· PUBMED
Publication
Chronic mitochondrial DNA depletion alters MAPT splicing and increases tau levels.
29 Sept 2026· Journal of Alzheimer's disease : JAD· PUBMED
Publication
APOE and amyloid-tau pathology in cognitively unimpaired older adults.
27 Sept 2026· Alzheimer's & dementia (Amsterdam, Netherlands)· PUBMED
Publication
CSF neuroinflammatory biomarkers are associated with amyloid-β42/40, tau pathology, and cognitive impairment across the Alzheimer's disease spectrum.
25 Sept 2026· Immunologic research· PUBMED
Publication
Rational design, synthesis, and biological evaluation of indole-piperazine based α-ketoamide derivatives as dual Aβ and tau aggregation modulators for Alzheimer's disease.
24 Sept 2026· European journal of medicinal chemistry· PUBMED
Publication
Ionizing radiation and Alzheimer's disease: epidemiology, mechanisms, and eCIRP-mediated tau pathology.
22 Sept 2026· Frontiers in immunology· PUBMED
Publication
Measuring in-vivo tau pathology in the basal forebrain with PET imaging.
22 Sept 2026· Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology· PUBMED
Publication
Decoding MAPT Exon 10 Mis-Splicing in FTDP-17: From Pathogenic Mechanisms and Experimental Models to Molecular Therapies.
19 Sept 2026· Genes· PUBMED
Publication
Neutrophil-to-lymphocyte ratio predicts early cognitive decline associated with tau pathology in Alzheimer's disease: a longitudinal study of the ADNI cohort.
16 Sept 2026· Frontiers in aging neuroscience· PUBMED
Publication
Targeting C/EBPβ/ Calbindin 1 pathway bolsters the neural resilience to tau pathology and improves tau-impaired episodic memory.
16 Sept 2026· Molecular psychiatry· PUBMED
Publication
Human tau pathology is associated with lonely, nontraveling slow waves linked to memory impairment.
11 Sept 2026· Nature neuroscience· PUBMED
Publication
Nanoconjugation of chalcone derivatives and carbon nitride dots for the inhibition of tau aggregation.
11 Sept 2026· Colloids and surfaces. B, Biointerfaces· PUBMED