Target

METTL3

N6-adenosine-methyltransferase catalytic subunit

2open trials
2trials in total
185publications
0researchers

Diseases

The last 24 months

New trials, publications, preprints and grants on this target, month by month.

TrialsPublicationsPreprintsGrants

Publication
METTL3-mediated m6A modification of DNMT1 enhances ovarian cancer progression.
4 Nov 2026· Science advances· PUBMED
Publication
METTL3-mediated N6-methyladenosine modification of UHRF1 promotes osteosarcoma malignancy through silencing SFRP1 via DNA methylation.
30 Oct 2026· Molecular biology reports· PUBMED
Publication
METTL3 destabilizes RFX7 to ameliorate PDGF-BB-induced airway smooth muscle cell dysfunction and inflammation in an in vitro model of childhood asthma.
20 Oct 2026· The Journal of asthma : official journal of the Association for the Care of Asthma· PUBMED
Publication
PRAME Augments K63-Linked Ubiquitination and Stabilization of METTL3 to Promote Lung Adenocarcinoma Metastasis.
19 Oct 2026· MedComm· PUBMED
Publication
Transient but not sustained p53 activation by targeting METTL3 prevents radiation-induced intestinal injury through dual-regulation of revival stem cells.
17 Oct 2026· Free radical biology & medicine· PUBMED
Publication
Cellular Morphological Profiling of PROTAC Degraders of the m6A RNA Methyltransferase METTL3.
6 Oct 2026· ACS bio & med chem Au· PUBMED
Publication
METTL3-mediated m6A modification of PARP2 accelerates hepatocellular carcinoma progression.
5 Oct 2026· Toxicology and applied pharmacology· PUBMED
Publication
The Role of METTL3-Mediated m6A Methylation in Hepatocellular Carcinoma Progression and Treatment.
4 Oct 2026· Epigenomes· PUBMED
Publication
METTL3 Increases Temozolomide Resistance in MGMT-Negative Glioblastoma by Enhancing CBX5 mRNA Stability in an m6A-IGF2BP2-Dependent Manner.
1 Oct 2026· CNS neuroscience & therapeutics· PUBMED
Publication
METTL3-mediated m⁶A methylation of E2F2 targets MCU to promote the malignant phenotype of gastric cancer cells.
1 Oct 2026· Cancer gene therapy· PUBMED
Publication
LncRNA MALAT1 Targets METTL3 to Orchestrate INPP5B/LRIG2 Signaling and Promote Non-Small Cell Lung Cancer Progression.
1 Oct 2026· Chemical biology & drug design· PUBMED
Publication
Epitranscriptomic stabilization of PGRMC1 by the METTL3-IGF2BP1 axis promotes ovarian cancer progression.
23 Sept 2026· Cellular signalling· PUBMED
Publication
METTL3‑mediated OTUB1 sustains PD‑L1 protein stability via deubiquitination and promotes immune evasion in oral squamous cell carcinoma.
23 Sept 2026· Molecular and cellular biochemistry· PUBMED
Publication
Kaempferol attenuates type 2 diabetic osteoporosis via METTL3/YTHDF2-regulated PTEN m⁶A methylation and ferritinophagy-ferroptosis inhibition.
18 Sept 2026· Pharmacological research· PUBMED
Publication
METTL3 Promotes the Growth of Triple-Negative Breast Cancer Cells by Modulating Ferroptosis-Related Oxidative Stress via the ELF1/GPX4 Axis.
7 Sept 2026· Asia-Pacific journal of clinical oncology· PUBMED
Publication
Correction: METTL3 facilitates tumor progression via an m6A-IGF2BP2-dependent mechanism in colorectal carcinoma.
5 Sept 2026· Molecular cancer· PUBMED
Publication
Mechanism of estrogen regulating the senescence and osteogenic differentiation of bone marrow mesenchymal stem cells via the METTL3/SATB2 axis.
4 Sept 2026· Pathology, research and practice· PUBMED
Publication
Licoisoflavone A ameliorates adipose tissue dysfunction in diet‑induced obesity by promoting METTL3 expression.
4 Sept 2026· Molecular medicine reports· PUBMED
Publication
Clerodendrum japonicum Extract Suppresses the Pathogenicity of Rheumatoid Arthritis Fibroblast-Like Synoviocytes by Inhibiting METTL3-Mediated ICAM2 mRNA Methylation.
1 Sept 2026· Cell biochemistry and function· PUBMED
Publication
METTL3 Promotes Lipid Deposition and Pulmonary Fibrosis by Destabilizing PLIN2 in a m6A-Dependent Manner.
1 Sept 2026· Journal of cellular and molecular medicine· PUBMED
Publication
METTL3-m6A-IGF2BP2 Axis-Mediated Stabilization of MTFR1 Promotes Glycolytic Reprogramming in Colorectal Cancer.
1 Sept 2026· Journal of gastroenterology and hepatology· PUBMED
Publication
Epitranscriptomic silencing of STK25 promotes ferroptosis evasion via the METTL3-YAP-GPX4 axis in osteosarcoma.
1 Sept 2026· Cancer letters· PUBMED
Publication
METTL3-mediated m6A modification exacerbates vascular endothelial inflammation in coronary artery disease by regulating DNMT1 mRNA stability.
31 Aug 2026· Experimental cell research· PUBMED
Publication
METTL3-Mediated m6A Modification of COL5A2 Inhibits Ferroptosis Through an IGF2BP3-dependent Mechanism in Gastric Cancer.
28 Aug 2026· Technology in cancer research & treatment· PUBMED
Publication
Targeting METTL3/m6A/SOCS3 axis reprograms tumor-associated macrophage polarization to potentiate the efficacy of anti-PD-1 therapy in multiple myeloma.
27 Aug 2026· Cellular and molecular life sciences : CMLS· PUBMED
Publication
Benzo[a]pyrene-induced METTL3 overexpression accelerates renal cell carcinoma progression via m6A modification of LTB4R mRNA and enhanced Treg infiltration.
21 Aug 2026· Ecotoxicology and environmental safety· PUBMED
Publication
The miR-338-5p/METTL3 axis regulates m6A modification to inhibit tumor progression in triple-negative breast cancer.
20 Aug 2026· Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico· PUBMED
Publication
The m6A/METTL3 modifies USP11 to promote Warburg effect progression of colon cancer undifferentiated by HIF-1α/YAP signaling pathway.
18 Aug 2026· Translational cancer research· PUBMED
Publication
Zfp217 Regulates Hepatic de Novo Lipogenesis via METTL3-Mediated N6-Methyladenosine Modification of SREBF1.
15 Aug 2026· FASEB journal : official publication of the Federation of American Societies for Experimental Biology· PUBMED
Publication
Nuclear m6A Methylase METTL3 Drives Production of ITGβ4E to Exacerbate Heart Failure via SRSF3-Mediated Alternative Splicing of ITGβ4.
15 Aug 2026· FASEB journal : official publication of the Federation of American Societies for Experimental Biology· PUBMED

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