New trials, publications, preprints and grants on this target, month by month.
Publication
P4HA3 promotes gastric cancer cell proliferation and invasion via the PI3K/AKT/mTOR signaling pathway and regulates glycolytic metabolic reprogramming.
1 Jan 2027· Pakistan journal of pharmaceutical sciences· PUBMED
Publication
N-Benzyl Indole-Benzoxazole Hybrids as Multi-Target Anticancer Agents Modulating mTOR, Apoptosis, and Lipid Dynamics in Breast Cancer.
6 Nov 2026· Turkish journal of pharmaceutical sciences· PUBMED
Publication
RHBDL2 promotes cancer stemness and chemoresistance in triple-negative breast cancer through EGFR/PI3K/AKT/mTOR/c-Myc pathway.
5 Nov 2026· Oncogene· PUBMED
Publication
Niwan Bazhen acupuncture activates CLEC3B-Mediated PI3K/AKT/mTOR signaling pathway to suppress autophagy and exerts neuroprotection against ischemic stroke.
5 Nov 2026· Neurochemical research· PUBMED
Publication
Chongcao Qingfei Capsule alleviates house dust mite-induced allergic airway inflammation by regulating metabolic homeostasis via modulation of the PDE7A-cAMP-AMPK-mTOR axis.
4 Nov 2026· Journal of ethnopharmacology· PUBMED
Publication
Oleanolic Acid and Ursolic Acid Alleviate Obesity-Induced Skeletal Muscle Atrophy via Activation of the IRS/PI3K/AKT/mTOR Signaling Pathway and Attenuation of Oxidative Stress.
4 Nov 2026· Journal of agricultural and food chemistry· PUBMED
Publication
Exogenous tryptophan aggravates experimental lung fibrosis through activation of AKT-mTORC1 pathway.
3 Nov 2026· PloS one· PUBMED
Publication
Characterization of cancer stem-like cells derived from a single 4T1 murine triple-negative breast cancer cell: Involvement of Akt‒mTOR pathway in the proliferation and sphere formation.
3 Nov 2026· Archives of biochemistry and biophysics· PUBMED
Publication
Adaptive induction of NFS1 links mTOR suppression to stemness-associated plasticity in glioblastoma.
3 Nov 2026· Journal of neuro-oncology· PUBMED
Publication
Aspartate inhibits mTORC1 activity and impairs reactivation of HIV-1 provirus.
2 Nov 2026· Journal of virology· PUBMED
Publication
Betaine Attenuates Cuprizone-Induced Cortical Demyelination: The Role of the WNT4/mTOR Signalling Pathway in Regulating Astrogliosis and Synaptic Integrity.
1 Nov 2026· Journal of biochemical and molecular toxicology· PUBMED
Publication
mTOR Inhibition Strategies in Oropharyngeal Carcinoma.
1 Nov 2026· Anticancer research· PUBMED
Publication
Dual mTORC1/2 and Scd1 inhibition uncovers a therapeutic vulnerability in pancreatic cancer.
31 Oct 2026· Oncogene· PUBMED
Publication
Dendrobium officinale extract ameliorates Alzheimer's disease by modulating PI3K-AKT-mTOR pathway and autophagy-related processes: An integrated study combining feature-based molecular networking, network pharmacology and multi-omics.
31 Oct 2026· Journal of ethnopharmacology· PUBMED
Publication
Synergistic effects of docetaxel and anti-PD-L1 therapy on prostate cancer cells: Modulation of apoptosis and PI3K/AKT/mTOR signaling pathway.
29 Oct 2026· Journal of cancer research and therapeutics· PUBMED
Publication
Dietary Leucine Restriction Suppresses Platelet-Driven HCC Growth by Attenuating mTOR Signaling.
28 Oct 2026· Cancer science· PUBMED
Publication
Tectochrysin alleviates idiopathic pulmonary fibrosis via inhibiting PI3K/AKT/mTOR signaling pathway by targeting PI3K p85.
28 Oct 2026· Pulmonary pharmacology & therapeutics· PUBMED
Publication
Relaxin-2 protects synaptic integrity via hippocampal NLRP3-mTOR-autophagy pathways in an age-dependent Alzheimer-like model.
26 Oct 2026· Acta pharmaceutica (Zagreb, Croatia)· PUBMED
Publication
Recombinant spinach ribosome-inactivating protein induces cytotoxicity and alters gene expression associated with PTEN/AKT/mTOR signaling, apoptosis, and stemness in HT29 cells.
23 Oct 2026· European journal of pharmacology· PUBMED
Publication
Corrigendum to "Sishen Wan suppresses colon cancer through dual inhibition of PI3K/AKT/mTOR and STAT3-mitophagy pathways: Network pharmacology and experimental validation" [J Ethnopharmacol, (2026), 360, 121039].
23 Oct 2026· Journal of ethnopharmacology· PUBMED
Publication
P2Y6 receptor activation promotes the migration, invasion and glycogen accumulation of colorectal cancer through AKT/mTOR signaling.
22 Oct 2026· Tissue & cell· PUBMED
Publication
Hyaluronan-Mediated Motility Receptor Potentiates Colorectal Carcinoma Progression Through PI3K/AKT/mTOR Pathway Modulation.
22 Oct 2026· Asia-Pacific journal of clinical oncology· PUBMED
Publication
Licorice flavonoids ameliorate type 2 diabetes mellitus via modulation of the AMPK/mTORC1/AKT signaling network.
22 Oct 2026· Journal of drug targeting· PUBMED
Publication
The potential impact of radiation-synthesized chitosan coated titanium dioxide nanoparticles on hepatocellular carcinoma: Modulation of autophagy via AMPK, mTOR, and ULK-1 pathways in a rat model.
20 Oct 2026· Bioorganic chemistry· PUBMED
Publication
NUAK isoforms promote glucose and glutamine metabolic reprogramming driven colon cancer progression and migration through regulation of AMPK/mTOR signaling.
20 Oct 2026· Journal of molecular medicine (Berlin, Germany)· PUBMED
Publication
The dual role of the PI3K/AKT/mTOR axis in glial cell survival and neuroinflammation.
17 Oct 2026· Naunyn-Schmiedeberg's archives of pharmacology· PUBMED
Publication
SEC31A promotes gastric cancer progression by inducing the PI3K/AKT/mTOR pathway and enhancing the CCL5‑mediated M2 polarization and recruitment of tumor‑associated macrophages.
16 Oct 2026· Oncology reports· PUBMED
Publication
Disporum cantoniense suppresses non‑small cell lung cancer through AMPK/mTOR/ULK1‑mediated autophagy‑dependent apoptosis.
16 Oct 2026· International journal of oncology· PUBMED
Publication
Bisphenol A induces hepatotoxicity via a LAMP3-dependent impairment of mitophagic processing and reduced PI3K-AKT-mTOR signaling.
15 Oct 2026· Free radical biology & medicine· PUBMED
Publication
Retraction: The botanical drug PBI-05204, a supercritical CO2 extract of Nerium oleander, inhibits growth of human glioblastoma, reduces Akt/mTOR activities, and modulates GSC cell-renewal properties.
15 Oct 2026· Frontiers in pharmacology· PUBMED