Target

MYC

Myc proto-oncogene protein

Also: c-MYC, c-Myc

16open trials
32trials in total
411publications
0researchers

Diseases

The last 24 months

New trials, publications, preprints and grants on this target, month by month.

TrialsPublicationsPreprintsGrants

Trial
Prizloncabtagene Autoleucel (Prizlon-cel) for the Treatment of Relapsed or Refractory Large B-cell Lymphoma Post FDA Approved CAR T-cell Therapy
1 May 2027· PHASE2 · NOT_YET_RECRUITING· CTGOV
Publication
MYC in renal cell carcinoma pathogenic mechanisms and pharmacological intervention strategies.
5 Nov 2026· Biochemical pharmacology· PUBMED
Publication
RHBDL2 promotes cancer stemness and chemoresistance in triple-negative breast cancer through EGFR/PI3K/AKT/mTOR/c-Myc pathway.
5 Nov 2026· Oncogene· PUBMED
Preprint
A KRT17/GATA6 hybrid state marks unique vulnerability to MYC in pancreatic cancer.
1 Nov 2026· Research square· PUBMED
Publication
A dual MYC and GSPT1 protein degrader for MYC-driven hematologic malignancies.
29 Oct 2026· Blood· PUBMED
Publication
LncRNA BCAR4 promotes tumorigenesis in triple-negative breast cancer by stabilizing the MYC-WDR5 complex.
26 Oct 2026· Acta biochimica et biophysica Sinica· PUBMED
Publication
AKT1-phosphorylated TERT assembles a FOXO3-MYC transcriptional complex that drives ERphagy and proteostasis in post-mitotic RPE.
26 Oct 2026· Autophagy· PUBMED
Publication
Targeting MYC in small cell lung cancer: Bridging molecular subtypes and therapeutic vulnerability.
23 Oct 2026· Lung cancer (Amsterdam, Netherlands)· PUBMED
Publication
Early WEE1 inhibition prevents senescence-like epigenetic reprogramming of pioneer TMZ-resistant cells and synergizes with temozolomide in MYC-high glioblastoma.
23 Oct 2026· Cancer letters· PUBMED
Publication
NDUFS1 promotes malignant breast cancer behaviors through enhancement of mitochondrial respiration and PROX1/c-Myc signaling.
19 Oct 2026· iScience· PUBMED
Publication
A novel dual-functional ligand targeting c-Myc and VEGF promoter G-quadruplexes for colorectal cancer therapy.
17 Oct 2026· Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy· PUBMED
Publication
c-Myc Links TGF-β Signaling to Metabolic Control of HIV Reactivation in OM10.1 Cells.
16 Oct 2026· Microorganisms· PUBMED
Publication
BBOX1-AS1 mediates Lenvatinib resistance through IGF2BP1-dependent MYC mRNA stabilization.
15 Oct 2026· Biochemical and biophysical research communications· PUBMED
Publication
Optical genome mapping reveals a MYC-amplified ring chromosome arising through chromoanagenesis in AML.
15 Oct 2026· Blood· PUBMED
Publication
The NFIL3-MYC signaling axis: a novel therapeutic target and prognostic marker in high-risk multiple myeloma.
9 Oct 2026· Biomarker research· PUBMED
Publication
p53 wild-type/low c-Myc-expressing ONS76 pediatric medulloblastoma cells become senescent after gamma-irradiation and can be eliminated by senolytic substances.
8 Oct 2026· Cell death discovery· PUBMED
Publication
Co-targeting CDK2 and CDK9 inhibits MYC oncogenic programs and has anti-tumor effects in CIC-rearranged sarcoma.
7 Oct 2026· Communications medicine· PUBMED
Publication
A MYC-LDHA-MCT4 expression program marks an SPP1/TREM2-centered macrophage state in pancreatic ductal adenocarcinoma.
5 Oct 2026· Frontiers in immunology· PUBMED
Publication
A DNA G-Quadruplex-Targeting Ligand Suppresses c-MYC Expression: Implications for Gemcitabine‑Resistant Pancreatic Cancer.
2 Oct 2026· Angewandte Chemie (International ed. in English)· PUBMED
Publication
MYC-Mediated USP39 Upregulation Stabilizes SRSF1 in Pancreatic Cancer.
2 Oct 2026· Molecular cancer research : MCR· PUBMED
Publication
Correction to: Prostate cancer cells' growth is decreased by novel MYC inhibitors.
1 Oct 2026· Investigational new drugs· PUBMED
Publication
Zinc Finger Protein 143 Bidirectionally Regulates the Proliferation of Hepatocytes and Hepatocellular Carcinoma Cells via c-Myc.
1 Oct 2026· Cell biochemistry and function· PUBMED
Publication
PLPP1 inhibits Wnt/β-catenin signaling via enhancing Caveolin-1/β-catenin interaction and is negatively regulated by c-Myc in osteosarcoma.
29 Sept 2026· Journal of orthopaedic translation· PUBMED
Publication
ZBTB1 Regulates Glycolysis and Chemotherapy Resistance Through Interacting with c-Myc in Triple Negative Breast Cancer.
29 Sept 2026· Cancers· PUBMED
Publication
MYC-Dependent rRNA Catabolism Stress Dictates Survival Heterogeneity of Hepatocellular Carcinoma Cells Under Glutamine Deprivation.
29 Sept 2026· Cancer research· PUBMED
Publication
SDCBP competes with CBL to stabilize PES1 and promote c-Myc translation in ESCC tumorigenesis.
22 Sept 2026· Cell reports· PUBMED
Publication
MYC-SNHG7-miR-34a-5p Feedback Loop Orchestrates GSDMD-Dependent Pyroptosis in Hepatocellular Carcinoma.
22 Sept 2026· International journal of molecular sciences· PUBMED
Publication
Molecular mechanism of augmentation of oncogenic activity of MYC by TAF2 in HCC.
18 Sept 2026· The Journal of biological chemistry· PUBMED
Publication
The NSDHL/c-Myc/PKM2 Axis Drives Glycolytic Reprogramming and Tumor Growth in Multiple Myeloma.
16 Sept 2026· International journal of molecular sciences· PUBMED
Publication
MYC-regulated long non-coding RNA SNHG1 controls S-phase kinase-associated protein 2-mediated p21 protein stability under thyroid hormone receptor signaling in hepatocellular carcinoma.
14 Sept 2026· International journal of biological macromolecules· PUBMED

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