New trials, publications, preprints and grants on this target, month by month.
Publication
Long non-coding RNA H19 knockout activates the SAHH/DNMT3b pathway and represses NLRP3 inflammasome expression in a diabetic rat model.
18 Nov 2026· International journal of ophthalmology· PUBMED
Publication
Atorvastatin inhibits PASMC proliferation in pulmonary hypertension via the TLR4/NF-κB/NLRP3/IL-1β pathway.
6 Nov 2026· Journal of cardiovascular pharmacology· PUBMED
Publication
Statement of Retraction: β-arrestin-2 alleviates rheumatoid arthritis injury by suppressing NLRP3 inflammasome activation and NF- κB pathway in macrophages.
5 Nov 2026· Bioengineered· PUBMED
Publication
7-Hydroxyflavone Attenuates Amyloid-β-Induced Alzheimer's Disease-Like Pathology Through Modulation of ROS/NLRP3 Inflammasome Signaling.
5 Nov 2026· Neurochemical research· PUBMED
Publication
Sirt1 Modulates p53‑Acetylation‑Dependent Yy2‑Elf‑1‑Associated NLRP3‑Relevant Signaling in CUMS‑Evoked Aggravated Alzheimer's Disease‑Related Phenotypes.
5 Nov 2026· Brain research bulletin· PUBMED
Publication
FSTL1 and NLRP3 Inflammasome Activation in Lupus Nephritis: A Mesenchyme-to-Macrophage Hypothesis.
4 Nov 2026· Immunological investigations· PUBMED
Publication
USP46 restrains K63-linked polyubiquitination-dependent aggregation and activation of the NLRP3 inflammasome in lupus nephritis.
4 Nov 2026· Proceedings of the National Academy of Sciences of the United States of America· PUBMED
Publication
Vaccarin ameliorates post-myocardial infarction ventricular remodeling by inhibiting NLRP3 inflammasome-mediated pyroptosis and cardiac fibrosis.
31 Oct 2026· International immunopharmacology· PUBMED
Publication
Circulating miR-223 and NLRP3 expression and their discriminatory performance in acute ischemic stroke.
29 Oct 2026· Personalized medicine· PUBMED
Publication
Integrative network pharmacology, machine learning, and experimental validation identify the TLR4/NF-κB/NLRP3 axis as a potential mechanism underlying the therapeutic effects of Lingguizhugan decoction in Alzheimer's disease.
29 Oct 2026· Journal of ethnopharmacology· PUBMED
Publication
Tetrandrine attenuates diabetic kidney disease by suppressing the TLR4-NF-κB-NLRP3 inflammatory signaling pathway in proximal tubular cells.
27 Oct 2026· International immunopharmacology· PUBMED
Publication
Corrigendum to "Trillin alleviates rheumatoid arthritis by inhibiting TXNIP-mediated mitochondrial damage and NLRP3-dependent pyroptosis" [Biochem. Pharmacol. 254 (2026) 118489].
26 Oct 2026· Biochemical pharmacology· PUBMED
Publication
Relaxin-2 protects synaptic integrity via hippocampal NLRP3-mTOR-autophagy pathways in an age-dependent Alzheimer-like model.
26 Oct 2026· Acta pharmaceutica (Zagreb, Croatia)· PUBMED
Publication
Overexpression of hippocampal AdipoR1 ameliorates cognitive dysfunction in APP/PS1 mice through inhibiting NLRP3-Mediated neuronal pyroptosis.
26 Oct 2026· Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics· PUBMED
Publication
Trilobatin attenuates allergic airway inflammation via multi-target suppression of NLRP3 inflammasome activation and caspase-3 signaling.
25 Oct 2026· Molecular biology reports· PUBMED
Publication
Calycosin alleviates blood-brain barrier disruption after cerebral ischemia-reperfusion injury by inhibiting NLRP3-mediated pyroptosis.
25 Oct 2026· Acta biochimica et biophysica Sinica· PUBMED
Publication
Targeting neuroinflammation in neuropsychiatric disorders: The role of NLRP3 inflammasome signalling.
24 Oct 2026· European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology· PUBMED
Publication
Chia seed oil attenuates titanium dioxide nanoparticles-induced ulcerative colitis in rats through suppression of NLRP3 inflammasome pathway "Histological and Molecular Study".
24 Oct 2026· Journal of molecular histology· PUBMED
Publication
Corrigendum to "Peroxynitrite activates NLRP3 inflammasome and contributes to hemorrhagic transformation and poor outcome in ischemic stroke with hyperglycemia" [Free Radic. Biol. Med. 165, (2021), 171-183].
22 Oct 2026· Free radical biology & medicine· PUBMED
Publication
Design, Synthesis, and Anti-Inflammatory Activity Evaluation of Novel thieno[2,3-d]Pyrimidin-4(3H)-One-Based NLRP3 Inflammasome Inhibitors.
22 Oct 2026· Journal of medicinal chemistry· PUBMED
Publication
Platycodon Decoction alleviates chronic obstructive pulmonary disease associated inflammation with potential dual-layer regulation of PI3K/AKT/NLRP3 signaling and ADGRE5-mediated intercellular interactions.
22 Oct 2026· Journal of ethnopharmacology· PUBMED
Publication
Promoting KAT5-Mediated CUL5 lactylation to downregulate MAVS/NLRP3 signaling in the hippocampus: The novel mechanisms underlying hydrogen sulfide-ameliorated cognitive dysfunction in Parkinson's disease.
22 Oct 2026· Free radical biology & medicine· PUBMED
Publication
Evaluating the NLRP3 inflammasome in chemotherapy-induced cognitive impairment: A multi-timepoint study of methotrexate and 5-fluorouracil in female rats.
21 Oct 2026· Behavioural brain research· PUBMED
Publication
Moderate-Dose Exercise Protects Against Heart Failure via Apelin/NLRP3 Mediated Inflammation.
20 Oct 2026· Reviews in cardiovascular medicine· PUBMED
Publication
NLRP3 signalling in NSCLC: distinguishing expression, inflammasome activation and context-dependent function.
20 Oct 2026· Frontiers in immunology· PUBMED
Publication
Hsp90 inhibitor 17-AAG reduces skin inflammation and inhibits NF-κB/NLRP3 inflammasome activation in DNCB-induced mice and TNF-α/IFN-γ-induced keratinocytes.
19 Oct 2026· Open life sciences· PUBMED
Trial
Vitamin E Versus Silymarin in Non Diabetic MASLD Patients
16 Oct 2026· PHASE3 · NOT_YET_RECRUITING· CTGOV
Publication
The NLRP3 Inflammasome Across the AKI-AKD-CKD Continuum: Mitochondrial, Epigenetic and Endocrine-Metabolic Regulation.
16 Oct 2026· International journal of molecular sciences· PUBMED
Publication
Caffeine and Exercise in Obesity-Associated Brain Aging and Neurodegeneration: Mechanistic Insights into AMPK/SIRT1/PGC-1α, BDNF/TrkB, and NLRP3 Inflammasome Signaling.
16 Oct 2026· Molecular neurobiology· PUBMED
Publication
Comment on "Association of peripheral NLRP3 inflammasome activation with prevalent and incident chronic kidney disease in patients with obstructive sleep apnea: a prospective study".
16 Oct 2026· Sleep & breathing = Schlaf & Atmung· PUBMED