Target

NOTCH1

Neurogenic locus notch homolog protein 1

1open trial
3trials in total
48publications
0researchers

Diseases

Chronic lymphocytic leukaemia2 trials
Diffuse large B-cell lymphoma1 trial

The last 24 months

New trials, publications, preprints and grants on this target, month by month.

TrialsPublicationsPreprintsGrants

Publication
NOTCH1 and ADORA3 define a novel transdifferentiation-related prognostic index for prognostic stratification in glioblastoma by integrating clinical factors.
12 Oct 2026· Brain research bulletin· PUBMED
Publication
Deubiquitination of NICD1 by USP10 Restrains Esophageal Cancer: A Link Between NOTCH1 Stabilization, Oxidative Stress, and Ferroptosis.
8 Sept 2026· Neoplasia (New York, N.Y.)· PUBMED
Publication
Pediatric T-cell lymphoblastic lymphoma with t(9;17)(q34;q23)-associated N-terminally truncated NOTCH1 activation: a case report.
2 Sept 2026· International journal of hematology· PUBMED
Publication
Stanniocalcin 1 contributes to glioma stem cells phenotypic plasticity through NOTCH1/STAT3/GFPT2 axis.
29 Aug 2026· Oncogenesis· PUBMED
Publication
Astragaloside IV attenuates hypoxia-reoxygenation-induced endothelial senescence and vascular inflammation by modulating the NOTCH1/VCAM-1 axis.
28 Aug 2026· Frontiers in aging neuroscience· PUBMED
Publication
Streptococcus salivarius Ss-08 Extracellular Vesicles Suppress OSCC Progression via Inhibition of JAG1-NOTCH1 Signaling.
25 Aug 2026· International journal of molecular sciences· PUBMED
Publication
ZMIZ1 promotes aerobic glycolysis and development of hepatocellular carcinoma through inducing NOTCH1-mediated transcription of PYCR1.
18 Aug 2026· Journal of translational medicine· PUBMED
Publication
ZMYM3 mutations modulate histone acetylation and cooperate with NOTCH1 mutations in chronic lymphocytic leukemia.
11 Aug 2026· Blood advances· PUBMED
Publication
Rab GTPases drive ligand-independent NOTCH1 activation via altered endocytic trafficking in chronic lymphocytic leukemia.
28 Jul 2026· HemaSphere· PUBMED
Publication
Therapeutic activation of PPARα contributes to NOTCH1 inhibition in T-cell acute lymphoblastic leukemia.
4 Jul 2026· BMC medicine· PUBMED
Publication
USP4-mediated deubiquitination of NOTCH1 inhibits HNSCC progression through regulating oxidative stress and ferroptosis.
3 Jul 2026· International immunopharmacology· PUBMED
Publication
Integrated bulk, single-cell, and spatial transcriptomic analyses prioritize NOTCH1 as a candidate gene associated with neurovascular and immune-related alterations in Parkinson's disease.
2 Jul 2026· Frontiers in neuroscience· PUBMED
Publication
FGFR3::TACC3 Fusion and NOTCH1 Loss-of-Function in a Case of HPV-Associated Sinonasal Squamous Cell Carcinoma: Diagnostic Challenge and Implications for Targeted Therapy.
30 Jun 2026· Head and neck pathology· PUBMED
Publication
Para-Coumaric Acid Suppresses Vascular Endothelial Growth Factor-Induced DLL4-NOTCH1 Signaling, Tumor Angiogenesis, and Tumor Growth.
19 Jun 2026· Pulse (Basel, Switzerland)· PUBMED
Publication
Hypoxia-induced upregulation of lncRNA SLC9A3-AS1 promotes lung adenocarcinoma progression through the miR-506-5p/ASPH/NOTCH1 pathway.
14 Jun 2026· Scientific reports· PUBMED
Publication
Not Missing the Notch: Detection Challenges of Juxtamembrane NOTCH1 Variant Detection in T-Cell Acute Lymphoblastic Leukemia.
8 Jun 2026· Journal of clinical laboratory analysis· PUBMED
Publication
Retraction notice to "LncRNA MACC1-AS1 facilitates the cell growth of small cell lung cancer by sequestering miR-579-3p and mediating NOTCH1-pathway" [Int. J. Biol. Macromol. 281 (2024) 136579].
14 May 2026· International journal of biological macromolecules· PUBMED
Publication
FHIT suppresses cervical squamous cell carcinoma progression by negatively regulating UBE2I-mediated SUMO modification of NOTCH1.
11 May 2026· Cellular signalling· PUBMED
Publication
Prognostic Significance of NOTCH1-ICD Expression in Renal Cell Carcinoma.
8 May 2026· Journal of kidney cancer and VHL· PUBMED
Publication
Two Faces of NOTCH1 in Childhood Lymphoblastic T-Cell Neoplasia: Prognostic Divergence of Mutational and Structural Aberrations.
7 May 2026· Pediatric blood & cancer· PUBMED
Publication
LncRNA LINC01579/miR-579-3p axis promotes gastric cancer progression via NOTCH1 pathway.
24 Apr 2026· World journal of surgical oncology· PUBMED
Publication
NOTCH1 acts as a tumor suppressor that induces early differentiation in head and neck cancer.
16 Apr 2026· JCI insight· PUBMED
Publication
Functional cooperation between the B-cell receptor and NOTCH1 in regulating metabolic reprogramming in chronic lymphocytic leukemia.
23 Mar 2026· Leukemia· PUBMED
Publication
Periodic Genetic Reanalysis Identifies a Novel De Novo NOTCH1 Variant: A Case Report.
15 Mar 2026· Journal of child neurology· PUBMED
Publication
Folate promotes colorectal cancer progression by impairing CD8+ T cell function and recruitment via SLC19A1/p-AKT/NOTCH1 axis and CCL5 downregulation.
13 Mar 2026· Journal of translational medicine· PUBMED
Publication
RNA‑binding protein DAZAP1 promotes gastric cancer metastasis by enhancing NOTCH1 and JAG1 mRNA stability.
6 Mar 2026· International journal of oncology· PUBMED
Publication
Decoding NOTCH1: From T-Cell Development Guardian to Driver of Pediatric T-Cell Lymphoblastic Lymphoma.
23 Feb 2026· International journal of molecular sciences· PUBMED
Publication
Expression of NOTCH1 Is Correlated with Expression of Cancer Stem Cell Markers and miR-150 in Oral Epithelial Dysplasia.
18 Feb 2026· International journal of molecular sciences· PUBMED
Publication
NOTCH1 and SF3B1 mutations in chronic lymphocytic leukemia with their clinical associations.
14 Feb 2026· Leukemia & lymphoma· PUBMED
Publication
Designing a Multi-Epitope Vaccine Against NOTCH1 and NOTCH4: A Computational Approach for Triple-Negative Breast Cancer.
18 Jan 2026· BioMed research international· PUBMED

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