Target

NPM1

Nucleophosmin

28open trials
39trials in total
96publications
0researchers

Diseases

The last 24 months

New trials, publications, preprints and grants on this target, month by month.

TrialsPublicationsPreprintsGrants

Trial
BSB-2002 After Cyclophosphamide and Fludarabine for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia Patients With NPM1 Mutation
14 Dec 2026· PHASE1 · NOT_YET_RECRUITING· CTGOV
Publication
Frequent FLT3 and IDH co-mutations in acute myeloid leukemia with mutated NPM1, NUP98 rearrangement, and KMT2A partial tandem duplication but not rearrangement: potential for combined targeted therapy.
5 Nov 2026· Haematologica· PUBMED
Publication
Targeting menin dependency in acute leukemias: the role of revumenib in NPM1-mutated and KMT2A/NUP98-rearranged disease.
29 Oct 2026· Future oncology (London, England)· PUBMED
Publication
Thrombotic and hemorrhagic complications in NPM1-mutated AML: Association with APL-like immunophenotype and impact on early mortality.
15 Oct 2026· Journal of thrombosis and thrombolysis· PUBMED
Publication
NPM1 mutations in AML: does size matter?
8 Oct 2026· Blood· PUBMED
Publication
Prognostic impact of variant allele frequency in intensively treated patients with NPM1-mutated AML: a PETHEMA study.
8 Oct 2026· Blood· PUBMED
Trial
Ziftomenib for the Treatment of Patients With NPM1 Mutated or KMT2A Rearranged Acute Myeloid Leukemia Not Eligible for Standard Therapy
1 Oct 2026· PHASE2 · RECRUITING· CTGOV
Publication
Better together in NPM1-mutated AML.
1 Oct 2026· Blood· PUBMED
Preprint
HLA-A*11:01-Restricted T Cell Receptors Targeting Mutant NPM1 for Adoptive Cell Therapy in Acute Myeloid Leukemia.
1 Oct 2026· bioRxiv : the preprint server for biology· PUBMED
Publication
Ziftomenib with venetoclax and azacitidine for relapsed/refractory NPM1-mutated acute myeloid leukemia.
1 Oct 2026· Blood· PUBMED
Publication
Targeting mutant NPM1-expressing AML with T cell receptor-like antibodies.
30 Sept 2026· iScience· PUBMED
Trial
A Study of CHM-029 in Participants With NPM1 Mutated, KMT2A or NUP98 Rearranged AML
28 Sept 2026· PHASE1 · RECRUITING· CTGOV
Publication
Two Decades of NPM1-Mutated Acute Myeloid Leukemia: From Molecular Insights to Clinical Decision-Making.
19 Sept 2026· Cancers· PUBMED
Publication
Prognostic Significance of Secondary-Type Mutations in NPM1-Mutated Acute Myeloid Leukemia.
1 Sept 2026· Cancer medicine· PUBMED
Publication
Relationship Between Salvage Strategy and Outcomes in Patients With CBF or NPM1-mutated AML and First Molecular Relapse.
1 Sept 2026· Blood advances· PUBMED
Publication
The GSEC-encoded polypeptide GESP drives colorectal cancer tumorigenesis via NPM1-c-Myc-mediated repression of NDRG1.
1 Sept 2026· Oncogene· PUBMED
Publication
Blasts Showing Apparent Engulfment of Apoptotic Debris in Apoptosis-Rich Acute Myeloid Leukemia With NPM1, FLT3-ITD, DNMT3A, and TET2 Mutations and Trisomy 8.
28 Aug 2026· International journal of laboratory hematology· PUBMED
Publication
Prognosis in NPM1 mutant acute myeloid leukemia: age and per-mutation permutations?
20 Aug 2026· Haematologica· PUBMED
Publication
Identification of the Characteristics and Prognostic Impact of t(3;5)(q25;q35)/NPM1::MLF1 Fusion Genes and NPM1 Mutations in Acute Myeloid Leukemia Patients.
20 Aug 2026· Clinical lymphoma, myeloma & leukemia· PUBMED
Publication
Unraveling the c-Myc-CASC19/HDAC1-NPM1 epigenetic axis: A novel regulatory circuitry and therapeutic target in gastric carcinogenesis.
18 Aug 2026· Cellular signalling· PUBMED
Publication
Clinical outcomes associated with NPM1 mutations in newly diagnosed acute myeloid leukemia.
15 Aug 2026· Cancer· PUBMED
Publication
Analytical validation of a modified wild-type blocker qpcr assay for the sensitive DNA-based detection of NPM1 type A in acute myeloid leukemia.
3 Aug 2026· Molecular biology reports· PUBMED
Publication
Co-phase separation of KRI1 and NPM1 sustains nucleolar integrity and ribosome biogenesis to fuel liver cancer progression.
3 Aug 2026· Proceedings of the National Academy of Sciences of the United States of America· PUBMED
Publication
Fragment mapping-guided virtual screening identifies a small-molecule modulator of NPM1 oligomerization.
30 Jul 2026· Computational biology and chemistry· PUBMED
Publication
IDH1 Mutations in Acute Myeloid Leukemia: Frequency and Clinical Features in the Context of FLT3 and NPM1 Co-Mutations-A Single-Center Study from Turkey.
24 Jul 2026· Current issues in molecular biology· PUBMED
Publication
Spontaneous Remission of Acute Myeloid Leukemia With Mutated NPM1 Following SARS-CoV-2 Infection.
24 Jul 2026· Case reports in hematology· PUBMED
Publication
Macrophage NPM1 drives anti-tumor immunity via the STAT3-CCRL2 axis.
22 Jul 2026· Frontiers in immunology· PUBMED
Publication
Case Report: Early T-cell precursor acute lymphoblastic leukemia with aberrant CD19 expression and an NPM1 mutation.
22 Jul 2026· Frontiers in oncology· PUBMED
Publication
Prognostic impact of age and MDS-associated mutations in NPM1-mutated AML.
16 Jul 2026· Blood neoplasia· PUBMED
Publication
Co-mutation signatures are age-dependent and impact the prognosis in NPM1-mutated acute myeloid leukemia: a PETHEMA multicenter study.
16 Jul 2026· Haematologica· PUBMED

Who works on it

Researchers who published on this target. Leave out your own co-author circle to find people you do not know yet.

No published researcher profile on this target yet.

We look for a fixed list of target names in titles, keywords, intervention names and MeSH terms. A mention does not prove that the work is aimed at that target.

Report an error