Target

NRF2

Nuclear factor erythroid 2-related factor 2

Also: NFE2L2, Nrf2

6open trials
9trials in total
1258publications
0researchers

Diseases

The last 24 months

New trials, publications, preprints and grants on this target, month by month.

TrialsPublicationsPreprintsGrants

Publication
NRF2 and mutant p53 separately regulate redox balance in esophageal squamous cell carcinoma through metabolic reprogramming.
6 Nov 2026· Cancer biology & therapy· PUBMED
Publication
Modulation of G6PD-mediated Vitamin C Sensitivity in Small Cell Lung Cancer by the AKT/NRF2 axis.
5 Nov 2026· The Journal of biological chemistry· PUBMED
Publication
Rubioncolin C promotes ferroptosis by down-regulating Nrf2/HO-1/GPX4 signaling, restricting colorectal cancer progression and tumor immune escape.
5 Nov 2026· International immunopharmacology· PUBMED
Publication
Boldine ameliorates metabolic dysfunction-associated steatotic liver disease via Nrf2-mediated mitochondrial and ferroptotic regulation.
4 Nov 2026· Archives of biochemistry and biophysics· PUBMED
Publication
Procyanidin B2 ameliorates osteoporosis by modulating osteoclast precursor differentiation through activation of the PI3K/Akt/Nrf2 axis.
4 Nov 2026· Bone· PUBMED
Publication
Salidroside Alleviates AlCl3/D-galactose-Induced Alzheimer's Disease-Like Mice Neuronal Damage and Synaptic Dysfunction Through Keap1/Nrf2/GSH Signaling Axis.
3 Nov 2026· Phytotherapy research : PTR· PUBMED
Publication
Sinensetin Induces Oxidative Stress-Mediated Apoptosis in Non-Small Cell Lung Cancer Cells by Suppressing Nrf2/ARE-Dependent Antioxidant Defense.
1 Nov 2026· Journal of biochemical and molecular toxicology· PUBMED
Publication
PPAR-γ/SGK1/GSK3β/Nrf2 signaling pathway contributes to the neuroprotective effects of lycopene in depressed mice.
29 Oct 2026· Journal of advanced research· PUBMED
Publication
Farrerol Attenuates Brain Injury After Intracerebral Hemorrhage and Modulates Nrf2 and TLR4/NF-κB Signaling.
29 Oct 2026· Molecular neurobiology· PUBMED
Publication
Withaferin A induces apoptosis and ferroptosis in gastric cancer cells via ROS-mediated mitochondrial damage and the Keap1/Nrf2/HO-1/GPX4 axis.
28 Oct 2026· Biochemical pharmacology· PUBMED
Publication
Dioscin Alleviates Diabetic Kidney Disease via Activation of the Nrf2/HO-1 Signaling Axis.
28 Oct 2026· Diabetes, metabolic syndrome and obesity : targets and therapy· PUBMED
Publication
ALDH2 Suppresses Ferroptosis and Promotes Bortezomib Resistance in Multiple Myeloma Through the KEAP1-NRF2 Feedback Loop.
28 Oct 2026· Advanced science (Weinheim, Baden-Wurttemberg, Germany)· PUBMED
Publication
Desoxo-narchinol A and water extract of Nardostachys jatamansi ameliorate house dust mite-induced atopic dermatitis by regulating Nrf2/HO-1 signaling.
27 Oct 2026· Fitoterapia· PUBMED
Publication
NRF2 modulation in colorectal cancer chemoprevention: integrating traditional medicine with translational strategies against oxidative stress, inflammation, and cancer stem cells.
24 Oct 2026· Naunyn-Schmiedeberg's archives of pharmacology· PUBMED
Publication
Engineered hUC-MSC exosomes loaded with pterostilbene induce Nrf2/SKN-1-dependent microglial M2 polarization and neuroprotection in Alzheimer's disease in vitro and in Caenorhabditis elegans.
23 Oct 2026· International immunopharmacology· PUBMED
Publication
Natural products target the NRF2-ferroptosis axis in hepatocellular carcinoma: tumor sensitization versus hepatoprotection.
22 Oct 2026· Frontiers in pharmacology· PUBMED
Publication
AFF3 regulates ferroptosis and malignant progression in bladder cancer cells via the NRF2/GPX4 signaling axis.
22 Oct 2026· European journal of histochemistry : EJH· PUBMED
Publication
NRF2-KEAP1 signaling in chromium-induced lung carcinogenesis: mechanistic insights and evidence gaps.
22 Oct 2026· Toxicology mechanisms and methods· PUBMED
Publication
NRF2 Suppresses Ferroptosis by Transcriptionally Regulating SLC7A11 to Promote Chemoresistance in Hepatocellular Carcinoma.
22 Oct 2026· The Tohoku journal of experimental medicine· PUBMED
Publication
Targeting the Keap1/Nrf2 pathway: Ginkgolide B mitigates oxidative stress and neuroinflammation in diabetic cognitive dysfunction.
21 Oct 2026· Experimental neurology· PUBMED
Publication
Selective NRF2 target induction despite falling NFE2L2 transcription across the MASLD spectrum: implications for marginal donor grafts and KEAP1-targeted therapy.
20 Oct 2026· Free radical biology & medicine· PUBMED
Publication
Correction: NRF2 signaling plays an essential role in cancer progression through the NRF2-GPX2-NOTCH3 axis in head and neck squamous cell carcinoma.
19 Oct 2026· Oncogenesis· PUBMED
Publication
Hesperidin-mediated selenium nanoparticles protect against diabetic cisplatin-induced testicular injury via modulation of Nrf2/Keap1, TLR4/NF-κB/MAPK, and PERK/CHOP Signaling.
19 Oct 2026· Tissue & cell· PUBMED
Publication
Daphnetin attenuates the early stage of adipogenesis via suppressing mitotic clonal expansion through Nrf2-mediated redox regulation.
19 Oct 2026· Food & function· PUBMED
Publication
Formononetin Protects Osteoblasts Against Oxidative Stress and Attenuates Ovariectomy-Induced Bone Loss in Association with MAPK/AP-1 and NRF2 Signaling.
19 Oct 2026· Antioxidants (Basel, Switzerland)· PUBMED
Publication
Renal tubule-specific Nrf2 deletion ameliorates diabetic kidney disease by attenuating glomerular hypertension and kidney injury in a mouse model of diabetes.
17 Oct 2026· Diabetologia· PUBMED
Publication
PBRM1 knockdown is associated with NRF2‑dependent ALDOA upregulation and metabolic reprogramming in HCCC‑9810 intrahepatic cholangiocarcinoma cells.
16 Oct 2026· Oncology reports· PUBMED
Publication
Sulforaphane Attenuates Ulcerative Colitis by Activating Nrf2 and Suppressing the NLRP3/IL-1β Inflammasome Axis.
16 Oct 2026· Current molecular medicine· PUBMED
Publication
Baicalein Ameliorates Postmenopausal Osteoporosis With Iron Accumulation by Inhibiting Osteoclastogenesis via Nrf2 Activation.
15 Oct 2026· FASEB journal : official publication of the Federation of American Societies for Experimental Biology· PUBMED
Publication
Needle-knife attenuates excessive autophagy and ferroptosis in post-stroke spastic hemiplegia: Association with SDC1/NRF2/SLC7A11/GPX4 pathway.
15 Oct 2026· Brain research bulletin· PUBMED

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