Target

PI3K

Phosphoinositide 3-kinase

Also: PI3K/AKT, PI3Kα, PI3Kδ

30open trials
67trials in total
1880publications
0researchers

Diseases

The last 24 months

New trials, publications, preprints and grants on this target, month by month.

TrialsPublicationsPreprintsGrants

Trial
Immunotherapy Plus Capivasertib for Metastatic Bladder Cancer
1 Jan 2027· PHASE1_PHASE2 · NOT_YET_RECRUITING· CTGOV
Publication
P4HA3 promotes gastric cancer cell proliferation and invasion via the PI3K/AKT/mTOR signaling pathway and regulates glycolytic metabolic reprogramming.
1 Jan 2027· Pakistan journal of pharmaceutical sciences· PUBMED
Trial
Aspirin and PAClitaxel in Head & Neck Squamous Cell Carcinoma
31 Dec 2026· PHASE2 · NOT_YET_RECRUITING· CTGOV
Trial
Roll-Over Study of Alpelisib (BYL719) for Continued Access and Long-Term Safety.
15 Dec 2026· PHASE2 · NOT_YET_RECRUITING· CTGOV
Publication
MiR-326 targets ETS1 to activate PI3K/Akt signaling and promote malignant phenotypes in gastric cancer cells.
1 Dec 2026· Pakistan journal of pharmaceutical sciences· PUBMED
Trial
A Study to Learn About the Study Medicine Called PF-08165784 in People With PIK3CA-Mutated Advanced or Metastatic Solid Tumors
9 Nov 2026· PHASE1 · NOT_YET_RECRUITING· CTGOV
Publication
RHBDL2 promotes cancer stemness and chemoresistance in triple-negative breast cancer through EGFR/PI3K/AKT/mTOR/c-Myc pathway.
5 Nov 2026· Oncogene· PUBMED
Publication
Niwan Bazhen acupuncture activates CLEC3B-Mediated PI3K/AKT/mTOR signaling pathway to suppress autophagy and exerts neuroprotection against ischemic stroke.
5 Nov 2026· Neurochemical research· PUBMED
Publication
Oleanolic Acid and Ursolic Acid Alleviate Obesity-Induced Skeletal Muscle Atrophy via Activation of the IRS/PI3K/AKT/mTOR Signaling Pathway and Attenuation of Oxidative Stress.
4 Nov 2026· Journal of agricultural and food chemistry· PUBMED
Publication
Icaritin enhances the anti-leukemic activity of imatinib in Philadelphia chromosome-positive B-cell acute lymphoblastic leukemia cells: functional involvement of PI3K/AKT signaling.
4 Nov 2026· Hematology (Amsterdam, Netherlands)· PUBMED
Publication
Targeting the PI3K/Akt/eNOS Pathway in Atherosclerosis: From Mechanotransduction to Emerging Therapies.
4 Nov 2026· The international journal of biochemistry & cell biology· PUBMED
Publication
IUPHAR Review:PI3Kδ in Cancer: From Biological Functions to Therapeutic Opportunities.
4 Nov 2026· Pharmacological research· PUBMED
Publication
Procyanidin B2 ameliorates osteoporosis by modulating osteoclast precursor differentiation through activation of the PI3K/Akt/Nrf2 axis.
4 Nov 2026· Bone· PUBMED
Publication
Correction: MAGOH promotes gastric cancer progression via hnRNPA1 expression inhibition-mediated RONΔ160/PI3K/AKT signaling pathway activation.
4 Nov 2026· Journal of experimental & clinical cancer research : CR· PUBMED
Publication
GLP-1 Enhances IL-27 Production in RAW264.7 Macrophages Via Activation of the PI3K/AKT Pathway.
2 Nov 2026· Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research· PUBMED
Publication
Midkine drives lung cancer brain metastasis via the NOTCH2/HES1 and PI3K/AKT pathways and serves as a prognostic biomarker.
2 Nov 2026· Cancer biomarkers : section A of Disease markers· PUBMED
Publication
Peptide profiling of casein peptide reveals its anti-diabetic effects via DPP-IV inhibition and IRS1/PI3K/AKT signaling.
2 Nov 2026· Food & function· PUBMED
Publication
SIRT7 Mediated-PTEN Desuccinylation Drives Gastric Tumorigenesis by Activating PI3K/AKT Pathway.
1 Nov 2026· Journal of biochemical and molecular toxicology· PUBMED
Publication
Epigenetic silencing of PDLIM4 promotes colorectal cancer by impairing BTF3 autophagic degradation and activating PI3K/Akt signalling.
1 Nov 2026· Clinical and translational medicine· PUBMED
Publication
SALL4 drives gastric cancer progression through PI3K/Akt-mediated regulation of glycolysis, EMT, stemness, and adhesion remodeling.
1 Nov 2026· Biochimica et biophysica acta. Gene regulatory mechanisms· PUBMED
Publication
Calycosin Promotes Ferroptosis in Cervical Cancer via the AMPK/PI3K-TFEB-Autophagy-Lysosome Axis.
1 Nov 2026· Journal of cellular biochemistry· PUBMED
Publication
MEF2A Promotes Keratinocyte Proliferation and Migration Under High-Glucose Conditions via Activation of the PI3K/AKT Signaling Pathway: Implications for Diabetic Wound Healing.
1 Nov 2026· The journal of gene medicine· PUBMED
Publication
Dendrobium officinale extract ameliorates Alzheimer's disease by modulating PI3K-AKT-mTOR pathway and autophagy-related processes: An integrated study combining feature-based molecular networking, network pharmacology and multi-omics.
31 Oct 2026· Journal of ethnopharmacology· PUBMED
Publication
LMP2A Promotes Immune Escape by Regulating PD-L1 Expression via the PI3K/AKT/STAT3 Axis in EBV-Positive Gastric Cancer.
30 Oct 2026· Experimental cell research· PUBMED
Publication
Astragaloside IV ameliorates combined allergic rhinitis and asthma syndrome by inhibiting the activation of the STAT6/GATA3/IL-4 and PI3K/AKT/NF-κB signaling pathways.
29 Oct 2026· Naunyn-Schmiedeberg's archives of pharmacology· PUBMED
Publication
Synergistic effects of docetaxel and anti-PD-L1 therapy on prostate cancer cells: Modulation of apoptosis and PI3K/AKT/mTOR signaling pathway.
29 Oct 2026· Journal of cancer research and therapeutics· PUBMED
Publication
Maoyu Extract Suppresses Non-Small Cell Lung Cancer Progression via PI3K/AKT Signaling Blockade: An Integrated Network Pharmacology and Experimental Validation Study.
29 Oct 2026· Applied biochemistry and biotechnology· PUBMED
Publication
4'-Hydroxywogonin Attenuates Hepatocellular Carcinoma Progression by Suppressing Gas6/Axl-PI3K/AKT Signaling.
28 Oct 2026· Phytotherapy research : PTR· PUBMED
Publication
Tectochrysin alleviates idiopathic pulmonary fibrosis via inhibiting PI3K/AKT/mTOR signaling pathway by targeting PI3K p85.
28 Oct 2026· Pulmonary pharmacology & therapeutics· PUBMED
Publication
Investigation of the effects of 1α,25-dihydroxyvitamin D3-supplemented electrochemotherapy on apoptosis and PI3K/PKC/NF-κB signaling pathway protein levels: an in vitro experimental study.
28 Oct 2026· Medical oncology (Northwood, London, England)· PUBMED

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