Target

PINK1

Serine/threonine-protein kinase PINK1

1open trial
1trial in total
169publications
0researchers

Diseases

Parkinson disease1 trial

The last 24 months

New trials, publications, preprints and grants on this target, month by month.

TrialsPublicationsPreprintsGrants

Publication
Lutein inhibits ATF3-mediated PINK1/Parkin signaling to modulate neuronal mitophagy and alleviate Parkinson's disease progression.
3 Nov 2026· Histology and histopathology· PUBMED
Publication
The N6-methyladenosine (m6A) reader YTHDF3 increases PINK1/Parkin-mediated mitophagy by facilitating prohibitin 2 (PHB2) translation to promote retinal ganglion cell damage in diabetic retinopathy.
1 Nov 2026· Journal of neuropathology and experimental neurology· PUBMED
Publication
E3 Ubiquitin Ligase RNF126 Contributes to Pathogenesis of Obesity by Induction Mitophagy Mediated by PINK1/Parkin Pathway.
31 Oct 2026· FASEB journal : official publication of the Federation of American Societies for Experimental Biology· PUBMED
Publication
Rhes as a Potential Modulator of PINK1/Parkin-Dependent Mitophagy in Huntington's Disease.
26 Oct 2026· Journal of integrative neuroscience· PUBMED
Publication
Sporoderm-Removed Particles Enhance Oxaliplatin Immunochemotherapy against Colorectal Cancer and Mitigate Neurotoxicity via Dual-Directional PINK1/Parkin Mitophagy.
21 Oct 2026· ACS applied materials & interfaces· PUBMED
Publication
A critical mechanistic synthesis of PINK1-mediated mitophagy signaling and its therapeutic targeting in Parkinson's disease neurodegeneration.
18 Oct 2026· Experimental neurology· PUBMED
Publication
PINK1-mediated mitophagy supports lung cancer initiation and limits the efficacy of KRAS-targeted therapy.
16 Oct 2026· Science advances· PUBMED
Publication
Low Expression of PINK1 Suppresses Mitophagy in Sonic Hedgehog-Driven Medulloblastoma in Association With Activation of the PI3K/AKT Signaling Pathway.
14 Oct 2026· Microscopy research and technique· PUBMED
Publication
Inhibition of PHB2/PINK1-mediated mitophagy potentiates venetoclax activity in acute myeloid leukemia.
13 Oct 2026· Leukemia· PUBMED
Publication
Mitochondrial DNA damage elicits PINK1 upregulation in pontine cholinergic neurons in Parkinson's disease.
7 Oct 2026· Brain : a journal of neurology· PUBMED
Publication
Plasma PINK1/Parkin ratio and ATF5 as potential biomarkers associated with dyskinesia in Parkinson's disease.
5 Oct 2026· Neurobiology of disease· PUBMED
Publication
Dabushen decoction ameliorates diabetes-associated cognitive dysfunction in association with changes in PINK1/Parkin-related mitophagy.
5 Oct 2026· Journal of ethnopharmacology· PUBMED
Publication
PINK1 promotes the progression of lung squamous cell carcinoma through the FAK/AKT/RhoA/vinculin pathway.
2 Oct 2026· Oncology reports· PUBMED
Publication
Neuroprotective effects of dapansutrile in rotenone-induced parkinsonism: targeting NLRP3/caspase-1, NF-κB, Nrf2/HO-1, and PINK1/Parkin pathways.
30 Sept 2026· Inflammopharmacology· PUBMED
Publication
Mitochondrial protein import stress in Parkinson's disease: the TOM/TIM-PINK1/Parkin-DELE1/HRI axis linking mitochondrial proteostasis to neuronal death.
28 Sept 2026· Frontiers in cell and developmental biology· PUBMED
Publication
Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf-1/ERK1/2/PINK1 Signaling Axis.
27 Sept 2026· Advanced science (Weinheim, Baden-Wurttemberg, Germany)· PUBMED
Publication
Sephin1 directly targets PHB2 to activate PINK1-PRKN-dependent mitophagy and alleviate α-synuclein neurotoxicity in Parkinson's disease models.
25 Sept 2026· Biochemical pharmacology· PUBMED
Publication
Targeting glial glycolysis with EGCG alleviates Parkinson's disease in a PINK1 mutant Drosophila model.
24 Sept 2026· Journal of ethnopharmacology· PUBMED
Publication
Navigating PINK1 Parkinson's Disease: Narratives of Pacific Patients and Caregivers.
24 Sept 2026· Parkinson's disease· PUBMED
Publication
Species-dependent activities of the PINK1-parkin axis.
18 Sept 2026· Translational neurodegeneration· PUBMED
Publication
Huangqi Guizhi Wuwu decoction suppresses experimental autoimmune encephalomyelitis by promoting PINK1/Parkin-mediated mitophagy and inhibiting microglial pyroptosis.
15 Sept 2026· Fitoterapia· PUBMED
Publication
A Non-canonical role of phloretin in renal protection: Targeting WNT2B downregulation to prime PINK1/ PARKIN-dependent mitophagy and attenuate renal fibrosis.
9 Sept 2026· Phytomedicine : international journal of phytotherapy and phytopharmacology· PUBMED
Publication
Targeting USP7 lactylation suppresses NSCLC tumorigenesis by promoting PINK1 ubiquitination and degradation.
9 Sept 2026· Autophagy· PUBMED
Publication
A new agent in the matrix: PINK1's expanded role in mitochondrial surveillance and regulation.
4 Sept 2026· Autophagy· PUBMED
Publication
The PINK1-VCP-p47 pathway protects against tau-induced dendritic shrinkage in cortical neurons through interaction with STIP1.
29 Aug 2026· Neurobiology of disease· PUBMED
Publication
POU2F1 promotes hypertensive cardiac fibrosis by regulating mitochondrial homeostasis through PINK1/Parkin‑dependent mitophagy.
28 Aug 2026· Molecular medicine reports· PUBMED
Publication
SREBF2 promotes mitophagy and protects against ferroptosis via Cav-1-regulated PINK1/Parkin signaling in ischemic heart failure.
27 Aug 2026· Journal of molecular medicine (Berlin, Germany)· PUBMED
Publication
FTO-mediated m6A demethylation of SNHG9 enhances PINK1-dependent mitophagy and reverses cisplatin resistance via nuclear EZH2 ubiquitination.
14 Aug 2026· Biochemical pharmacology· PUBMED
Publication
Parkinson's disease-associated PINK1 loss disrupts ensheathing glia and causes dopaminergic neuron synapse loss.
13 Aug 2026· eLife· PUBMED
Publication
Mitochondria-enriched BMSC exosomes restore microglia-neuron cross-talk in Parkinson's disease via PINK1/parkin and PI3K/Akt/mTOR pathways.
5 Aug 2026· Brain research· PUBMED

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