Target

PKD1

Polycystin-1

1open trial
3trials in total
39publications
0researchers

Diseases

Polycystic kidney disease3 trials

The last 24 months

New trials, publications, preprints and grants on this target, month by month.

TrialsPublicationsPreprintsGrants

Publication
Response to letter to the editor regarding "miRNA profiling of a mutation-negative PKD cohort reveals PKD1/PKD2 ADPKD shared signatures and differences".
4 Nov 2026· Epigenomics· PUBMED
Publication
Letter to the editor regarding: miRNA profiling of a mutation-negative PKD cohort reveals PKD1/PKD2 ADPKD shared signatures and differences.
31 Oct 2026· Epigenomics· PUBMED
Publication
The Dosage Logic of PKD1: RNA Regulation and Therapeutic Derepression.
26 Oct 2026· Journal of the American Society of Nephrology : JASN· PUBMED
Publication
Case Report: Early-onset portal hypertension revealing pediatric ADPKD with a truncating PKD1 variant.
1 Oct 2026· Frontiers in pediatrics· PUBMED
Publication
CRISPR activation of endogenous PKD1 increases polycystin-1 levels and suppresses cellular features of ADPKD.
21 Sept 2026· American journal of physiology. Renal physiology· PUBMED
Publication
The Importance of Familial Co-segregation in the Classification of a Novel PKD1 Variant Associated With Autosomal Dominant Polycystic Kidney Disease.
6 Sept 2026· American journal of medical genetics. Part A· PUBMED
Publication
Imaging features of TSC2/PKD1 contiguous gene deletion syndrome in adults.
4 Sept 2026· Abdominal radiology (New York)· PUBMED
Publication
Case Report: Functional validation of a PKD1 c.7489 + 5G>A variant in an ADPKD family.
6 Aug 2026· Frontiers in genetics· PUBMED
Publication
Scoping Review on Polycystic Liver Disease in PKD1/PKD2 Gene Carriers: Genetic Aspects, Pathophysiology, and Therapeutic Approaches.
5 Aug 2026· Journal of clinical and experimental hepatology· PUBMED
Publication
PKD1 upstream open reading frames affect Polycystin-1 expression and polycystic kidney disease phenotypes.
28 Jul 2026· The Journal of clinical investigation· PUBMED
Publication
A new conceptual framework for PKD1 in ADPKD; integrating DNA structures and inflammation.
11 Jul 2026· BMC nephrology· PUBMED
Publication
Biallelic PKD1 mutations causing neonatal death in an extremely preterm infant: a Korean case report of very early-onset ADPKD.
13 Jun 2026· BMC nephrology· PUBMED
Publication
Neural SMG7 deficiency induces autism-like behaviours via PKD1 upregulation.
6 Jun 2026· Brain : a journal of neurology· PUBMED
Publication
Genome and transcriptome sequencing reveal pathogenic activation of a pseudoexon in PKD1 via a de novo-common variant complex allele.
26 May 2026· Genetics in medicine open· PUBMED
Preprint
CRISPR activation of endogenous PKD1 increases polycystin-1 levels and suppresses cellular features of ADPKD.
25 May 2026· bioRxiv : the preprint server for biology· PUBMED
Publication
Systemic inflammatory biomarkers linked to PKD1 mutation and renal morphometrics in cats with polycystic kidney disease.
24 Apr 2026· Veterinary world· PUBMED
Publication
miRNA profiling of a mutation-negative PKD cohort reveals PKD1/PKD2 ADPKD shared signatures and differences.
2 Apr 2026· Epigenomics· PUBMED
Publication
Targeting PI3Kγ anchoring enhances CFTR membrane localization and modulator efficacy via PKD1.
23 Mar 2026· JCI insight· PUBMED
Publication
Generation of a human-induced pluripotent stem cell line (NUMNi003-A) from a patient with autosomal dominant polycystic kidney disease harboring a PKD1 gene variant.
16 Mar 2026· Stem cell research· PUBMED
Publication
Comprehensive genomic profiling of triple-negative breast cancer metastases identifies role of PKD1 in immunotherapy resistance.
2 Mar 2026· The Journal of clinical investigation· PUBMED
Publication
TSC2/PKD1 contiguous gene deletion syndrome.
1 Mar 2026· Kidney international· PUBMED
Publication
Glycolytic alterations as biomarkers in polycystic kidney disease: A study using a PKD1 knockout model in NRK-52E rat kidney epithelial cells.
1 Mar 2026· Physiological reports· PUBMED
Publication
Reversible cystogenesis in juvenile primate ADPKD models: evidence from PKD1 heterozygous monkeys.
23 Feb 2026· Human molecular genetics· PUBMED
Publication
BICC1 interacts with PKD1 and PKD2 to drive cystogenesis in ADPKD.
12 Feb 2026· eLife· PUBMED
Publication
Case Report: A case of ruptured renal epithelioid angiomyolipoma leading to the diagnosis of TSC2/PKD1 contiguous gene syndrome.
6 Feb 2026· Frontiers in pediatrics· PUBMED
Publication
Correction: Integrative multi-omics analyses identify PKD1 and SLC2A4 as genetically supported glycolysis-related candidate genes for rheumatoid arthritis.
29 Jan 2026· Frontiers in immunology· PUBMED
Publication
An intronic micro-deletion impacts the transcription and translation of PKD1 gene.
23 Jan 2026· Frontiers in genetics· PUBMED
Publication
Integrative multi-omics analyses identify PKD1 and SLC2A4 as genetically supported glycolysis-related candidate genes for rheumatoid arthritis.
22 Jan 2026· Frontiers in immunology· PUBMED
Publication
Disruption of a six-nucleotide miRNA motif improves PKD1 dosage and ameliorates polycystic kidney disease.
14 Jan 2026· Nucleic acids research· PUBMED
Publication
Mendelian randomization analysis of PKD1 in endometrial cancer and comparative multi-cancer study with renal cell carcinoma.
13 Jan 2026· Discover oncology· PUBMED

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