Target

PKM2

Pyruvate kinase PKM

0open trials
1trial in total
117publications
0researchers

Diseases

Childhood cancers1 trial
Colorectal cancer1 trial

The last 24 months

New trials, publications, preprints and grants on this target, month by month.

TrialsPublicationsPreprintsGrants

Publication
piR-34379 inhibits bladder cancer progression and reverses cisplatin resistance by downregulating ACAT2-mediated PKM2 lactylation.
3 Nov 2026· Cellular signalling· PUBMED
Publication
Targeting PKM2-dependent glycolysis reprogrammes monocytes into Cadm1+ macrophages to promote mucosal repair and attenuate colitis progression.
2 Nov 2026· Gut· PUBMED
Publication
Molecular mechanism of ephedrine-regulated ferroptosis in asthma via PKM2-ACSL4 lactylation.
1 Nov 2026· Pakistan journal of pharmaceutical sciences· PUBMED
Publication
Melatonin Mitigates Doxorubicin-Induced Cardiotoxicity by Targeting the USP18/PKM2 Axis Without Compromising Antitumor Efficacy.
26 Oct 2026· Advanced science (Weinheim, Baden-Wurttemberg, Germany)· PUBMED
Publication
Shikonin Promotes Apoptosis in Multiple Myeloma Cells Through the PKM2-AMPK-PGC1α Metabolic Axis.
20 Oct 2026· Journal of clinical laboratory analysis· PUBMED
Publication
RNF34 restrains endometriosis progression by promoting PKM2 ubiquitination and suppressing glycolysis.
17 Oct 2026· Cellular signalling· PUBMED
Publication
KSHV vIRF3-PKM2 interaction induces SMAD5 acetylation, promoting Kaposi's sarcoma progression.
5 Oct 2026· Experimental & molecular medicine· PUBMED
Publication
PPP1CA drives osteosarcoma tumorigenesis by promoting PKM2 dephosphorylation and tetramerization.
2 Oct 2026· Molecular cancer research : MCR· PUBMED
Publication
ALYREF regulates glycolysis and promotes the progression of endometrial cancer through m5C modification of PKM2 mRNA.
2 Oct 2026· Frontiers in cell and developmental biology· PUBMED
Publication
Fisetin Induces Apoptosis and Inhibits Migration of Melanoma Cells by Suppressing Glycolytic Metabolism via PKM2 Inhibition.
1 Oct 2026· Annals of dermatology· PUBMED
Publication
FBP1-Mediated Compartmentalization of Glycolytic Enzyme Complexes Suppresses PKM2 Function to Ameliorate MASLD Progression.
27 Sept 2026· Advanced science (Weinheim, Baden-Wurttemberg, Germany)· PUBMED
Publication
SphK1 membrane targeting acts on PKM2 succinylation to fuel synovial hyperplasia in rheumatoid arthritis.
26 Sept 2026· International immunopharmacology· PUBMED
Publication
Auto-S-fatty Acylation of PKM2 Regulates its Tetramerization and Glycolytic Metabolism in Cancer Cells.
26 Sept 2026· Journal of molecular biology· PUBMED
Publication
YBX3 promotes ischemia-reperfusion injury by enhancing microglial glycolysis via PKM2 stabilization and mTOR-HIF-1α pathway activation.
24 Sept 2026· Behavioural brain research· PUBMED
Publication
NAT-A exhibits anti-tumor activity against acquired epidermal growth factor receptor- tyrosine kinase inhibitor-resistant non-small cell lung cancer via inhibiting the β-catenin/PKM2 axis.
24 Sept 2026· Translational oncology· PUBMED
Publication
Physcion attenuates renal fibrosis by disrupting PKM2-FAK1 interaction and suppressing the FAK1/ERK signaling axis.
24 Sept 2026· Phytomedicine : international journal of phytotherapy and phytopharmacology· PUBMED
Publication
Histone Lactylation-mediated PKM2 promotes gemcitabine resistance in pancreatic adenocarcinoma via the AKT/mTOR/SREBP1 Axis.
23 Sept 2026· Biochimica et biophysica acta. General subjects· PUBMED
Publication
TRIM28 facilitates diffuse large B-cell lymphoma progression by inducing glycolytic reprogramming through the E2F1/PKM2 axis.
19 Sept 2026· Naunyn-Schmiedeberg's archives of pharmacology· PUBMED
Publication
The deubiquitinating enzyme UCHL3 promotes bladder cancer progression and glycolysis through enhancing PKM2 protein stability.
18 Sept 2026· Frontiers in oncology· PUBMED
Publication
OLFM4 promotes intrahepatic cholangiocarcinoma progression through a PKM2-glycolysis-histone lactylation feedback loop.
18 Sept 2026· International journal of biological sciences· PUBMED
Publication
The NSDHL/c-Myc/PKM2 Axis Drives Glycolytic Reprogramming and Tumor Growth in Multiple Myeloma.
16 Sept 2026· International journal of molecular sciences· PUBMED
Publication
PKM2 AP: a micropeptide inhibits vascular calcification via molecular glue-mediated ubiquitination of PKM2.
12 Sept 2026· Nature communications· PUBMED
Publication
Smilax glabra flavonoids ameliorate non-alcoholic steatohepatitis by regulating PKM2-dependent glycolysis and suppressing AIM2 inflammasome activation.
9 Sept 2026· Frontiers in immunology· PUBMED
Publication
Targeting PKM2 Enhances the Anti-Tumor Function of CD8+ T Cells Through Metabolic Reprogramming.
27 Aug 2026· International journal of molecular sciences· PUBMED
Publication
"Trojan" Methionine Probe Reveals PKM2 as a Methionine-Sensing Protein in the mTORC1 Pathway.
26 Aug 2026· Journal of the American Chemical Society· PUBMED
Publication
GLI1 activation induced by intermittent hypoxia drives cardiac fibroblast activation via enhanced PKM2-mediated glycolysis.
24 Aug 2026· European heart journal· PUBMED
Publication
Plumbagin Is a PKM2 Activator That Modulates Glutamine Metabolism and Dependency in Leukemia.
16 Aug 2026· Metabolites· PUBMED
Publication
NAT10-mediated ac4C acetylation of PKM2 promotes papillary thyroid carcinoma through regulating glycolysis.
10 Aug 2026· Journal of molecular histology· PUBMED
Publication
PKM2 is the Metabolic Checkpoint for Stemness Features in Head and Neck Cancer.
10 Aug 2026· Journal of Cancer· PUBMED
Publication
Expression, association with clinicopathological features and prognostic potential of FOXR2, mTOR, HIF-1α and PKM2 in high-grade serous carcinoma of the ovary.
8 Aug 2026· Diagnostic pathology· PUBMED

Who works on it

Researchers who published on this target. Leave out your own co-author circle to find people you do not know yet.

No published researcher profile on this target yet.

We look for a fixed list of target names in titles, keywords, intervention names and MeSH terms. A mention does not prove that the work is aimed at that target.

Report an error