Target

PPAR

Peroxisome proliferator-activated receptor

Also: PPARα, PPARγ, PPARδ

3open trials
7trials in total
1393publications
0researchers

Diseases

Fatty liver disease (MASLD/MASH)2 trials
Bipolar disorder1 trial
Primary biliary cholangitis1 trial
Stroke1 trial
Type 2 diabetes1 trial

The last 24 months

New trials, publications, preprints and grants on this target, month by month.

TrialsPublicationsPreprintsGrants

Publication
Chronotherapy leveraging dietary context overcomes circadian rhythm influence on cancer cell response to PPAR antagonists.
6 Nov 2026· Cell reports· PUBMED
Publication
RXR-PPAR-γ axis in adolescent depression: PPAR-γ coactivator 1α links cognition and appetite hormones.
6 Nov 2026· Journal of the Chinese Medical Association : JCMA· PUBMED
Publication
HIF-1α/PPAR-γ/SIRT1 axis drives astrocyte senescence and regulates endothelial function via GDNF/NRTN in diabetic retinopathy.
6 Nov 2026· PloS one· PUBMED
Publication
Electroacupuncture Alleviates Migraine Possibly by Regulating KAT and Inhibiting nNOS Expression via the PGC-1α/PPARα/δ Signaling Pathway.
5 Nov 2026· Neurochemical research· PUBMED
Publication
Fibroblast growth factor 10 (FGF10) ameliorates pulmonary arterial hypertension by restoring endothelial mitochondrial function and reducing DNA damage via the PPARγ pathway.
3 Nov 2026· Vascular pharmacology· PUBMED
Publication
BBR-RHE Co-Loaded Nanoemulsion Potentiates Anti-PD-L1 Efficacy via Lipid Metabolic Reprogramming in Triple-Negative Breast Cancer.
2 Nov 2026· Molecular pharmaceutics· PUBMED
Publication
BAM15 improves oocyte quality against obesity via PPARγ-dependent mitochondrial function.
1 Nov 2026· Protein & cell· PUBMED
Publication
Xiaoshen formula delays progression of diabetic kidney disease and improves glucose and lipid metabolism: Association with the JAK/STAT pathway.
1 Nov 2026· Pakistan journal of pharmaceutical sciences· PUBMED
Publication
Myeloid-Derived Growth Factor Alleviates Diabetic Non-Alcoholic Fatty Liver Disease by Up-Regulating ABCA1 and ABCG1 Expression via the AMPK/PPARγ/LXRα Pathway.
1 Nov 2026· Journal of cellular and molecular medicine· PUBMED
Publication
QHHP Ameliorates MASH Through Modulation of a Cyp4a32-PPARγ-CD36-Associated Lipotoxic Axis.
31 Oct 2026· FASEB journal : official publication of the Federation of American Societies for Experimental Biology· PUBMED
Publication
Correspondence to letter to the editor on "DNMT1 facilitates the progression of metabolic dysfunction-associated steatotic liver disease by impeding transcription mediated by HNF4α and PPARα".
30 Oct 2026· Clinical and molecular hepatology· PUBMED
Publication
Impaired NK Cell-Mediated Tumor Surveillance in Atherosclerosis Due to Plaque-Induced PPARα Dysfunction.
29 Oct 2026· Arteriosclerosis, thrombosis, and vascular biology· PUBMED
Publication
Fam172a deletion exacerbates hepatic steatosis and alters SRSF3-associated PPARγ isoform regulation.
29 Oct 2026· Molecular metabolism· PUBMED
Publication
PPAR-γ/SGK1/GSK3β/Nrf2 signaling pathway contributes to the neuroprotective effects of lycopene in depressed mice.
29 Oct 2026· Journal of advanced research· PUBMED
Publication
Differential modulation of PPAR-γ and aromatase by pharmacotherapeutics in Danio rerio ovaries: Mechanistic insights for PCOS therapy.
26 Oct 2026· Gene expression patterns : GEP· PUBMED
Publication
Hydroxysafflor yellow A ameliorates progression of endometriosis via regulating PPAR-γ/PTEN/Akt axis.
26 Oct 2026· Tissue & cell· PUBMED
Publication
Fufang Xianzhuli Ye attenuates airway inflammation and epithelial injury in experimental asthma: involvement of PI3K-Akt and PPAR-γ signaling and associated lipid metabolic changes.
24 Oct 2026· Journal of natural medicines· PUBMED
Publication
RXR-PPAR-γ axis dysregulation and executive dysfunction in first-episode schizophrenia and bipolar I disorder: An exploratory study.
24 Oct 2026· Asian journal of psychiatry· PUBMED
Publication
PPARγ Activation Rescues High‑Fat Diet‑Induced Obesity Exacerbated Food Allergy by Maintaining Intestinal Homeostasis.
23 Oct 2026· The Journal of nutritional biochemistry· PUBMED
Publication
Cannabidiol Regulates Amyloid-β Plaque Deposition and Astrogliosis in the 5xFAD Transgenic Mouse Model.
22 Oct 2026· Journal of molecular neuroscience : MN· PUBMED
Publication
FATP5 loss in hepatocellular carcinoma cells orchestrates tumor-promoting microenvironment by inducing passive long-chain fatty acid accumulation within tumor-associated endothelial cells.
22 Oct 2026· Oncogene· PUBMED
Publication
The Effect of Stevioside on Hepatic Steatosis in Metabolic Dysfunction-Associated Steatotic Liver Disease.
21 Oct 2026· Journal of agricultural and food chemistry· PUBMED
Publication
Dietary butyrate alleviates high-fat diet-induced colonic mucosal impairment accompanied by increased gut-derived indole-3-acetic acid and enhanced PPARγ signaling.
21 Oct 2026· Frontiers in endocrinology· PUBMED
Publication
Furan fatty acids reprogram hepatic lipid metabolism via acyl-CoA conjugates in obesity.
21 Oct 2026· Science advances· PUBMED
Publication
PPARγ signaling pathway: strategies and limitations of natural compounds in the treatment of ulcerative colitis.
20 Oct 2026· Frontiers in pharmacology· PUBMED
Publication
Citri reticulatae pericarpium viride attenuates metabolic dysfunction-associated steatotic liver disease by activating PGC-1α-mediated fatty acid oxidation in mice.
19 Oct 2026· Food & function· PUBMED
Publication
Correction: GNPAT promotes immunosuppression in hepatocellular carcinoma by activating the plasmalogen-PPARγ pathway to drive M2 macrophage polarization.
19 Oct 2026· Frontiers in immunology· PUBMED
Publication
Intestinal microbiota-associated LysoPC(16:0) promotes endometriosis via PPARγ-mediated M2 macrophage polarization and IL-10 secretion.
15 Oct 2026· iScience· PUBMED
Publication
Compartment-specific PPARδ activity controls the outcome of cancer-immune cell competition and immunotherapy efficacy.
14 Oct 2026· Nature immunology· PUBMED
Publication
A diarylheptanoid from Alpinia officinarum ameliorates insulin resistance in 3T3-L1 adipocytes and db/db mice through modulation of PPARγ/PI3K/AKT signaling pathway.
14 Oct 2026· Frontiers in pharmacology· PUBMED

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