New trials, publications, preprints and grants on this target, month by month.
Publication
The influence of mutant genes APP and PSEN1 on hippocampal asymmetry in 5xFAD mice, transgenic model of Alzheimer disease.
1 Oct 2026· Vavilovskii zhurnal genetiki i selektsii· PUBMED
Publication
PSEN1 Expression Identifies a Developmentally Distinct Favourable-Prognosis State in SHH α Medulloblastoma.
1 Oct 2026· International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience· PUBMED
Publication
Social Determinants and Brain Health in PSEN1 E280A Carriers vs Non-Carriers: A Colombian Cohort.
22 Sept 2026· American journal of Alzheimer's disease and other dementias· PUBMED
Publication
Correlations of PSEN1, PSEN2, and APP missense variants on the production of Aβ peptides against variant effect prediction.
7 Sept 2026· Alzheimer's & dementia (New York, N. Y.)· PUBMED
Publication
Lecanemab in symptomatic PSEN1 p.Met233Val early-onset Alzheimer's disease: Neuroimaging safety, regional amyloid-PET dynamics, and longitudinal plasma biomarkers.
30 Aug 2026· Alzheimer's & dementia (Amsterdam, Netherlands)· PUBMED
Preprint
Astrocyte-driven small vessel disease is an early, amyloid-independent feature of PSEN1 E280A familial Alzheimer's disease.
22 Jul 2026· bioRxiv : the preprint server for biology· PUBMED
Publication
Patient-Derived PSEN1 Cerebral Organoids Revealed Parallel Development of Amyloid-β Accumulation and Network Dysfunction.
20 Jul 2026· Cellular and molecular neurobiology· PUBMED
Publication
A Novel p. (Leu173del) Mutation in the Presenilin 1 (PSEN1) Gene in Two Sisters with Dominantly Inherited Alzheimer's Disease.
18 Jul 2026· Internal medicine (Tokyo, Japan)· PUBMED
Publication
Baseline and placebo-related imaging, cerebrospinal fluid, plasma biomarker, and cognitive findings in unimpaired PSEN1 E280A mutation carriers and non-carriers in the Alzheimer's Prevention Initiative Autosomal Dominant Alzheimer's Disease Colombia Trial.
17 Jul 2026· EBioMedicine· PUBMED
Trial
A Study of Donanemab, RG6289, or the Combination of Donanemab and RG6289 in Presenilin 1 (PSEN1) E280A Mutation Carriers for the Treatment of Autosomal-Dominant Alzheimer's Disease
8 Jul 2026· PHASE2_PHASE3 · RECRUITING· CTGOV
Publication
Novel PSEN1 (Q223 L) mutation causes early-onset Alzheimer's disease: A case report.
28 Jun 2026· World journal of radiology· PUBMED
Publication
Diagnostic challenges in early-onset Alzheimer's disease: Case report of a patient with PSEN1 p.Asn135Ser mutation.
24 Jun 2026· Journal of Alzheimer's disease reports· PUBMED
Publication
A Humanized Knock-in Mouse Model of the PSEN1 V97L Mutation from a Major Chinese Alzheimer's Disease Pedigree Reveals Early Neuroinflammation.
23 Jun 2026· Neuroscience bulletin· PUBMED
Publication
Teaching Video NeuroImage: Beyond Cognition: Amyotrophic Lateral Sclerosis-Like Disease in PSEN1 c.1292C>A (Jalisco Founder Effect) Variant.
19 Jun 2026· Neurology· PUBMED
Publication
Hypertrophic Cardiomyopathy and Sudden Cardiac Arrest Associated with a PSEN1 Variant: A Case Report.
4 Jun 2026· Internal medicine (Tokyo, Japan)· PUBMED
Publication
Regulatory Variation at TERT and TERC Shows Limited Association with Early-Onset Alzheimer's Disease in Carriers of the Mexican Founder Mutation PSEN1 A431E.
30 Apr 2026· Medical sciences (Basel, Switzerland)· PUBMED
Preprint
PSEN1 mutant marmoset fibroblasts mimic multi-omic signatures of Alzheimer's disease.
28 Apr 2026· bioRxiv : the preprint server for biology· PUBMED
Publication
[Early-onset Alzheimer's disease with PSEN1 G206D mutation presenting with amnesia at an onset age of 29 years old].
11 Apr 2026· Rinsho shinkeigaku = Clinical neurology· PUBMED
Publication
Retraction notice to "Generation of a gene-corrected human isogenic iPSC line from an Alzheimer's disease iPSC line carrying the PSEN1 H163R mutation" [Stem Cell Res. 79 (2024) 103495].
19 Mar 2026· Stem cell research· PUBMED
Publication
Differential effects of PSEN1 mutations (p.P117L with ataxia and p.P264L without ataxia) in early-onset Alzheimer's disease.
16 Mar 2026· Journal of Alzheimer's disease : JAD· PUBMED
Publication
Generation of a human induced pluripotent stem cell line (FLENIi004-A) from an Autosomal-Dominant Alzheimer's disease PSEN1 p.M146L patient.
6 Mar 2026· Stem cell research· PUBMED
Publication
Heterozygous TREM2 (p.W44X) and PSEN1 (p.A431T) mutations in two Peruvian families with familial Alzheimer's disease: expanding the genetic landscape in underrepresented populations.
2 Feb 2026· Frontiers in neuroscience· PUBMED
Publication
Novel prognostic signature unveils PSEN1 contributes to depression-induced lung adenocarcinoma progression.
29 Jan 2026· Frontiers in immunology· PUBMED
Publication
A novel PSEN1 (p.Gln223Leu) variant associated with spastic paraparesis and early-onset Alzheimer's disease.
28 Jan 2026· Journal of Alzheimer's disease reports· PUBMED
Publication
The preliminary study on the effect of PSEN1 on the proliferation and invasion of breast cancer cells.
21 Jan 2026· Translational breast cancer research : a journal focusing on translational research in breast cancer· PUBMED
Publication
Interpretable machine-learning prediction of PSEN1 missense variant pathogenicity based on multi-omics enrichment in six core Alzheimer's disease genes.
8 Jan 2026· Alzheimer's research & therapy· PUBMED
Publication
Papaverine-Derived Dual-Active Modulator Ameliorates Alzheimer's Disease Pathology in Aged APP/PSEN1 Transgenic Mice.
31 Dec 2025· Journal of medicinal chemistry· PUBMED
Publication
Efficacy of lecanemab in early-onset Alzheimer's disease with a novel PSEN1 (p.Met233Thr) mutation: a case report.
20 Dec 2025· Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology· PUBMED
Publication
Clinical and functional evidence supporting the pathogenicity of the novel PSEN1 p.R358P variant in early-onset Alzheimer's disease.
6 Nov 2025· Journal of Alzheimer's disease : JAD· PUBMED
Publication
Hyperkinesia and early-onset dementia in a female with co-occurring PSEN1 and HTT mutations: A case report.
3 Nov 2025· Journal of Alzheimer's disease reports· PUBMED