New trials, publications, preprints and grants on this target, month by month.
Publication
Resistant hypertension and accelerated vascular aging: evidence for PTEN-AKT-associated cellular senescence.
5 Nov 2026· GeroScience· PUBMED
Publication
AKT is necessary for neuronal hypertrophy and epilepsy caused by Pten knockout.
4 Nov 2026· Brain : a journal of neurology· PUBMED
Publication
SIRT7 Mediated-PTEN Desuccinylation Drives Gastric Tumorigenesis by Activating PI3K/AKT Pathway.
1 Nov 2026· Journal of biochemical and molecular toxicology· PUBMED
Publication
PELO links PTEN loss to JAK1/STAT1-mediated inflammation and prostate tumor progression by stabilizing JAK1-PIK3R3 interactions.
31 Oct 2026· Cell death and differentiation· PUBMED
Publication
Atractylenolide III alleviates MASLD by inhibiting lipid synthesis and apoptosis via PTEN.
28 Oct 2026· Phytomedicine : international journal of phytotherapy and phytopharmacology· PUBMED
Publication
Cost-effectiveness of capivasertib plus abiraterone for PTEN-deficient metastatic hormone-sensitive prostate cancer in the United States.
26 Oct 2026· PloS one· PUBMED
Publication
Hydroxysafflor yellow A ameliorates progression of endometriosis via regulating PPAR-γ/PTEN/Akt axis.
26 Oct 2026· Tissue & cell· PUBMED
Publication
Recombinant spinach ribosome-inactivating protein induces cytotoxicity and alters gene expression associated with PTEN/AKT/mTOR signaling, apoptosis, and stemness in HT29 cells.
23 Oct 2026· European journal of pharmacology· PUBMED
Publication
Capivasertib plus abiraterone in PTEN-deficient de novo metastatic hormone-sensitive prostate cancer: updated survival analysis from CAPItello-281.
23 Oct 2026· Annals of oncology : official journal of the European Society for Medical Oncology· PUBMED
Publication
PTEN-loss confers dependence on the guanylate synthesis enzyme IMPDH in T-cell acute lymphoblastic leukemia.
15 Oct 2026· EMBO molecular medicine· PUBMED
Publication
Histopathological and immunohistochemical analyses do not indicate timing of prophylactic hysterectomy: a retrospective analysis of endometrial biopsies in Lynch syndrome carriers.
15 Oct 2026· Familial cancer· PUBMED
Publication
Correction: Xie et al. Kaempferol Promotes Apoptosis in Human Bladder Cancer Cells by Inducing the Tumor Suppressor, PTEN. Int. J. Mol. Sci. 2013, 14, 21215-21226.
10 Oct 2026· International journal of molecular sciences· PUBMED
Publication
Co-mutation patterns and survival associations in lung cancer: a comparative analysis of Swedish and global cohorts.
9 Oct 2026· Acta oncologica (Stockholm, Sweden)· PUBMED
Publication
Passenger co-deletion confounds glutaminolysis signatures anchored on PTEN loss: A cautionary case for location-aware signature design.
9 Oct 2026· PloS one· PUBMED
Publication
[New advances in thyroid tumors associated with genetic syndromes].
8 Oct 2026· Zhonghua bing li xue za zhi = Chinese journal of pathology· PUBMED
Publication
Phosphatase and tensin homolog (PTEN) drives perivascular adipose tissue (PVAT) dysfunction in rats fed a high-sugar diet.
8 Oct 2026· European journal of pharmacology· PUBMED
Publication
Gypenoside LI modulates autophagy-associated apoptosis in clear cell renal cell carcinoma by PPARG/PTEN/PI3K/AKT/mTOR/ULK1 signaling network.
8 Oct 2026· Frontiers in pharmacology· PUBMED
Publication
Targeted Hotspot Mutation Analysis of KRAS, TP53, and PTEN in Endometrial Cancer Revealed by Next-Generation Sequencing.
6 Oct 2026· Current oncology (Toronto, Ont.)· PUBMED
Publication
The long isoform of FABP6 facilitates WWP2-mediated PTEN ubiquitination to activate AKT/mTOR signalling and contributes to reduced everolimus sensitivity in clear cell renal cell carcinoma.
1 Oct 2026· Clinical and translational medicine· PUBMED
Publication
Senescence-associated prostate cancer cells promote fibroblast reprogramming and extracellular matrix remodeling.
1 Oct 2026· Neoplasia (New York, N.Y.)· PUBMED
Publication
NLRC4 Acts as a Non-Canonical Tumour Suppressor in Lung Adenocarcinoma by Inhibiting PI3K/AKT/mTOR Signalling to Induce Protective Autophagy.
1 Oct 2026· Journal of cellular and molecular medicine· PUBMED
Publication
HnRNPA1-Regulated miR-23a-3p Promotes Hepatocellular Carcinoma Metastasis by Targeting the PTEN Signaling Pathway.
30 Sept 2026· Anti-cancer agents in medicinal chemistry· PUBMED
Publication
Association of Copy Number Variations in PTEN with Autism Spectrum Disorder.
24 Sept 2026· Genes· PUBMED
Publication
TET1 loss promotes malignant phenotypes in HeLa cells and is associated with altered PTEN-PI3K/AKT/mTOR signaling.
24 Sept 2026· Frontiers in oncology· PUBMED
Publication
Peripheral Blood Mononuclear Cell Expression Profile of Proliferation-, Ferroptosis-, and Immune-Related Targets in Breast Cancer.
23 Sept 2026· Medicina (Kaunas, Lithuania)· PUBMED
Publication
Actionable genetic landscape and dynamics in circulating DNA from 12,827 patients with metastatic breast cancer.
22 Sept 2026· Nature communications· PUBMED
Publication
Young Aggressive Prostate Tumors Exhibit Increased Genomic Instability and an Exploratory RNA-CNA-Concordant Transcriptomic Pattern.
18 Sept 2026· International journal of molecular sciences· PUBMED
Publication
Kaempferol attenuates type 2 diabetic osteoporosis via METTL3/YTHDF2-regulated PTEN m⁶A methylation and ferritinophagy-ferroptosis inhibition.
18 Sept 2026· Pharmacological research· PUBMED
Publication
Ubiquitylation by the GID/CTLH complex regulates the metabolic and innate immune response of macrophages to infection by Mycobacterium tuberculosis.
18 Sept 2026· PLoS pathogens· PUBMED
Publication
The clinical and phenotypic spectrum of PTEN hamartoma tumor syndrome: a retrospective cohort study.
17 Sept 2026· Familial cancer· PUBMED