New trials, publications, preprints and grants on this target, month by month.
Trial
Periodontal Status and Biomarkers in MASLD
26 Feb 2027· NA · NOT_YET_RECRUITING· CTGOV
Publication
Icariin Ameliorates Postmenopausal Osteoporosis by Modulating Phosphodiesterase 5A-Mediated RANKL/OPG Signaling.
15 Nov 2026· FASEB journal : official publication of the Federation of American Societies for Experimental Biology· PUBMED
Publication
S100A9 Induces RANKL Expression in Osteocytes Utilizing IL-6/sIL-6R Combination and gp130 Signaling Pathways.
31 Oct 2026· FASEB journal : official publication of the Federation of American Societies for Experimental Biology· PUBMED
Publication
Recombinant RANKL protects against brain injury in intracerebral haemorrhage by regulating microglial phenotypes via the STAT3 pathway.
29 Oct 2026· Brain injury· PUBMED
Publication
SERCA2/CaMKIIγ axis in osteocytes regulates RANKL-mediated osteoclastogenesis in response to mechanical loading.
28 Oct 2026· Cellular signalling· PUBMED
Publication
161Tb radiopharmaceutical therapy as a treatment for RANKL-positive multiple myeloma.
10 Oct 2026· European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences· PUBMED
Publication
Traditional Chinese medicine regulating Wnt/β-catenin and OPG/RANKL/RANK pathways in osteoporosis: a narrative review based on bone coupling and pathological subtype differences.
16 Sept 2026· Frontiers in medicine· PUBMED
Publication
A dual-action humanized DKK-1 antibody that activates the Wnt/β-catenin signaling pathway and inhibits the RANKL signaling pathway for osteoporosis therapy.
27 Aug 2026· Frontiers in immunology· PUBMED
Publication
Case Report: Synergistic potential of RANKL and ACLY inhibition in a breast cancer patient with acquired resistance to CDK4/6 inhibitors.
26 Aug 2026· Frontiers in oncology· PUBMED
Publication
Development and Internal Validation of a Nomogram Model Based on Serum OPG and RANKL for Identifying Low Physical Health-Related Quality of Life Status in Patients with Rheumatoid Arthritis.
18 Aug 2026· Modern rheumatology· PUBMED
Publication
Role of the Antioxidant Lycopene in Bone Health: Emphasis on the RANKL/RANK/OPG Signaling Pathway.
13 Aug 2026· Food science & nutrition· PUBMED
Publication
Targeting RANKL Prevents Bone Loss, Improves Muscle Function and Extends Lifespan in Progeroid Mice.
1 Aug 2026· Aging cell· PUBMED
Publication
RANKL-convergent osteoimmune network framework in osteoporosis: integrating macrophage activation, T-cell imbalance, and cytokine crosstalk.
29 Jul 2026· Frontiers in immunology· PUBMED
Publication
Fucoidan from giant kelp alleviates postmenopausal osteoporosis by regulating the betaine-OPG/RANKL/RANK signaling axis.
24 Jul 2026· Food research international (Ottawa, Ont.)· PUBMED
Publication
A DNA aptamer targeting RANKL and its nanoparticle-mediated delivery ameliorate osteoporotic bone loss.
10 Jul 2026· International journal of biological macromolecules· PUBMED
Publication
Inhibition of membrane RANKL production in osteoblasts mediates curcumin-inhibited osteoclastogenesis.
10 Jul 2026· Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas· PUBMED
Publication
Impact of Simulated Obesity in Animals on RANK/RANKL/OPG Pathway During Orthodontic Tooth Movement.
2 Jul 2026· Orthodontics & craniofacial research· PUBMED
Publication
Spermidine mitigates glucocorticoid-induced bone osteoporosis by targeting oxidative stress and RANKL/OPG pathway.
28 Jun 2026· Tissue & cell· PUBMED
Publication
IL-34-mediated fibroblast-like synoviocyte-macrophage crosstalk drives bone erosion in rheumatoid arthritis through RANKL-dependent osteoclastogenesis.
17 Jun 2026· Frontiers in immunology· PUBMED
Publication
Machine Learning-Driven Prediction of Low BMD in Postmenopausal Women Using Cytokine, RANKL/OPG, and Oxidative Stress Biomarker Signatures: An Exploratory Study.
16 Jun 2026· Biomedicines· PUBMED
Publication
RANKL-RANK signaling promotes cigarette smoke-induced emphysema with MMP-9 upregulation in alveolar macrophages.
15 Jun 2026· Frontiers in pharmacology· PUBMED
Publication
Natto May Alleviate Retinoic Acid-Induced Osteoporosis by Activating Gut Microbiota-Bile Acid Axis and OPG/RANKL Signaling Pathway.
14 Jun 2026· Nutrients· PUBMED
Publication
Critical Overview of Molecular Insights into Osteoarthritis and Therapeutic Targets: Cytokines, RANKL, MMPs, Adipokines and Phosphate Dysregulation.
11 Jun 2026· International journal of molecular sciences· PUBMED
Publication
Dental Tissue-Derived Mesenchymal Stem Cells Modulate Mitochondrial and OPG/RANKL Signaling in Obesity-Associated Osteoporosis Under Estrogen-Deficient and Intact Conditions.
10 Jun 2026· Biomedicines· PUBMED
Publication
Proinflammatory autoantibodies enhancing tumor necrosis factor and RANKL signaling in axial spondyloarthritis associate with hyperphosphorylated progranulin and osteoprotegerin.
5 Jun 2026· Annals of the rheumatic diseases· PUBMED
Publication
A RANKL-derived Peptide Inhibits RSPO3-LGR4-Wnt Signaling and Lung Adenocarcinoma in Mice.
1 Jun 2026· Anticancer research· PUBMED
Publication
Evaluation of Osteoprotegerin (OPG) and Receptor Activator of Nuclear Factor Kappa-B Ligand (RANKL) Biomarker Concentrations in the Saliva of Patients with Periodontitis and Depression.
1 Jun 2026· Clinical and experimental dental research· PUBMED
Publication
RANKL Inhibition and the Risk of Ocular Hypertension and Primary Open-Angle Glaucoma.
1 Jun 2026· Investigative ophthalmology & visual science· PUBMED
Publication
Type 2 Diabetes Impairs Alveolar Socket Healing: Immunohistochemical Analysis of Del-1, IL-17, RANKL, and OPG Expression in a Rat Model.
30 May 2026· International journal of dentistry· PUBMED
Publication
Alogliptin-metformin synergy ameliorates diabetes-associated bone loss via modulation of DPP-4 activity and OPG/RANKL signaling.
28 May 2026· 3 Biotech· PUBMED