Target

RPGR

X-linked retinitis pigmentosa GTPase regulator

2open trials
15trials in total
18publications
0researchers

Diseases

Retinitis pigmentosa15 trials

The last 24 months

New trials, publications, preprints and grants on this target, month by month.

TrialsPublicationsPreprintsGrants

Publication
Genetic Insights Into Retinitis Pigmentosa: A De Novo RPGR Mutation in an Iranian-Azeri Family.
17 Aug 2026· Case reports in ophthalmological medicine· PUBMED
Publication
Efficacy and safety of AAV RPGR gene therapy in X-linked retinitis pigmentosa: a systematic review and meta-analysis.
10 Aug 2026· Journal of translational medicine· PUBMED
Publication
Functional Outcomes and Ocular Safety of Subretinal AAV-RPGR Gene Therapy for RPGR-Associated X-Linked Retinitis Pigmentosa: A Systematic Review and Meta-Analysis.
7 Aug 2026· Journal of clinical medicine· PUBMED
Publication
Defining a Novel RPGR Phenotype of Sector Retinitis Pigmentosa With Cone Dystrophy.
3 Aug 2026· Investigative ophthalmology & visual science· PUBMED
Publication
Clinical and Genetic Landscape of RPGR -Associated Retinal Dystrophies in Portugal: Insights From the Nationwide IRD-PT Registry.
28 Jul 2026· Clinical & experimental ophthalmology· PUBMED
Publication
First Exonic Cryptic Branchpoint Variant in an Inherited Retinal Degeneration Detected in an Irish RPGR Pedigree with X-Linked Retinitis Pigmentosa.
21 Jun 2026· Genes· PUBMED
Publication
Optimized AAV5-RPGR ORF15 Gene Therapy Rescues Photoreceptor Structure and Function in X-Linked Retinitis Pigmentosa Mouse Model.
9 Jun 2026· American journal of ophthalmology· PUBMED
Publication
Pathogenic mechanisms of RPGR mutations in X-linked retinitis pigmentosa: integrating clinical pedigree and single-cell transcriptomics.
2 Jun 2026· Frontiers in genetics· PUBMED
Publication
The quality-of-life impacts and economic burden of X-linked retinitis pigmentosa caused by variants in RPGR.
21 May 2026· Eye (London, England)· PUBMED
Publication
Insights into retinal disease and non-tubulin glutamylation from a RPGR-TTLL5 complex structure.
3 Apr 2026· The Journal of cell biology· PUBMED
Publication
Loss of RPGR disrupts motile cilia and causes primary ciliary dyskinesia by affecting F-actin dynamics.
31 Mar 2026· The Journal of clinical investigation· PUBMED
Publication
Efficacy and Safety of Gene Therapy for RPGR Gene-Associated X-Linked Retinitis Pigmentosa: A Systematic Review and Meta-Analysis.
2 Mar 2026· Translational vision science & technology· PUBMED
Publication
Decline of Visual Function and Risk of Legal Blindness With Age in RPGR -Associated Retinal Degeneration: A Multicenter Study.
27 Feb 2026· Clinical & experimental ophthalmology· PUBMED
Publication
Genotypic and phenotypic landscape of novel RPGR variants in patients from Western Canada.
2 Feb 2026· Canadian journal of ophthalmology. Journal canadien d'ophtalmologie· PUBMED
Publication
Advances in RPGR gene therapy for X‑linked retinitis pigmentosa: From preclinical insights to clinical application (Review).
2 Jan 2026· International journal of molecular medicine· PUBMED
Publication
Age-Stratified Genetic Spectrum of Retinitis Pigmentosa in Korean Patients: Predominance of RPGR Variants in Early-Onset Disease.
29 Dec 2025· Annals of laboratory medicine· PUBMED
Publication
Visual Field Estimation in X-Linked Retinitis Pigmentosa Associated with Retinitis Pigmentosa GTPase Regulator (RPGR) from Image Analysis Using Artificial Intelligence.
8 Dec 2025· Ophthalmology science· PUBMED
Publication
A human-specific RPGR isoform and a clinically approved Rho/ROCK inhibitor ameliorate defects associated with RPGR dysfunction.
31 Oct 2025· Molecular therapy. Nucleic acids· PUBMED
Trial
A Phase 2 Open-label Study to Evaluate the Safety of Laruparetigene Zovaparvovec Administered Bilaterally in Male Participants With X-Linked Retinitis Pigmentosa
10 Sept 2025· PHASE2 · ACTIVE_NOT_RECRUITING· CTGOV

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