Target

SCN1A

Sodium channel protein type 1 subunit alpha

6open trials
8trials in total
22publications
0researchers

Diseases

Epilepsy8 trials

The last 24 months

New trials, publications, preprints and grants on this target, month by month.

TrialsPublicationsPreprintsGrants

Publication
SCN1A (C>T) rs3812718 Polymorphism and Phenytoin-Induced Adverse Drug Reactions: Genotyping Versus Therapeutic Drug Monitoring in a Prospective Cohort.
6 Nov 2026· Therapeutic drug monitoring· PUBMED
Publication
Gene therapy for epilepsy: From SCN1A to broadened therapeutic horizons (Review).
6 Nov 2026· Molecular medicine reports· PUBMED
Publication
[Analysis of clinical phenotypes and pathogenicity of a c.4476+5G>T variant of SCN1A gene in a Chinese pedigree affected with Genetic epilepsy with febrile seizures plus].
10 Oct 2026· Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics· PUBMED
Publication
Cenobamate in Dravet syndrome with electrophysiologically confirmed SCN1A loss-of-function variants: long-term real-world follow-up.
23 Sept 2026· Frontiers in pharmacology· PUBMED
Publication
From targeted SCN1A analysis to whole exome sequencing: clinical utility and novel genetic findings in a Hungarian paediatric epilepsy cohort.
29 Aug 2026· Human genetics· PUBMED
Publication
Molecular Analysis of SCN1A Gene Variants Associated with Dravet Syndrome: Implications for Diagnosis and Management.
13 Jul 2026· Turkish archives of pediatrics· PUBMED
Publication
From electroclinical phenotype to adult SCN1A diagnosis: Insights from the correspondence between Carlo Alberto Tassinari and Charlotte Dravet.
29 Jun 2026· Epileptic disorders : international epilepsy journal with videotape· PUBMED
Publication
Novel Variants in PLPBP, SCN1A, and SLC6A1: Genetics, Bioinformatics, and clinical Elucidation of Three Distinct Cases of Developmental and Epileptic Encephalopathy.
17 Jun 2026· Journal of neurogenetics· PUBMED
Publication
The role of SCN1A mutations in temporal lobe epilepsy: Genetic insights and clinical implications.
8 Jun 2026· Epileptic disorders : international epilepsy journal with videotape· PUBMED
Publication
Disrupted inhibitory interneuron development in SCN1A Dravet syndrome revealed by patient-derived subpallial organoids.
5 May 2026· Epilepsia· PUBMED
Publication
Genetic Polymorphisms in SCN1A Gene (rs6432860) and Pharmacoresistance to Antiepileptic Drugs Among Jordanian Patients with Epilepsy.
30 Apr 2026· Pharmaceuticals (Basel, Switzerland)· PUBMED
Publication
Clinical characteristics and genetic analysis of patients with SCN1A gene pathological variant-related disorders: a single-center retrospective study.
27 Apr 2026· Italian journal of pediatrics· PUBMED
Publication
Elicited Repetitive Daily Blindness Associated With Gain-of-Function SCN1A Variants and Responsiveness to Sodium Channel Blockers.
22 Apr 2026· Neurology. Genetics· PUBMED
Publication
Association of SCN1A and SCN2A Gene Polymorphisms with Antiseizure Medication Responsiveness: A Case-Control Study from Eastern India.
10 Apr 2026· Annals of Indian Academy of Neurology· PUBMED
Publication
CACNA2D2 rs56287038:G>T and SCN1A rs2298771:C>T Variants Are Associated with Antiseizure Medication Response in Turkish Epilepsy Patients: A Pilot Study.
10 Apr 2026· Neuropsychobiology· PUBMED
Publication
SCN1A Developmental and Epileptic Encephalopathy: From Seizures to Status Dystonicus.
19 Mar 2026· Movement disorders clinical practice· PUBMED
Publication
Epilepsy-Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties.
20 Feb 2026· Annals of clinical and translational neurology· PUBMED
Publication
A SCN1A missense variant (c.4522T>A, p.(Tyr1508Asn) associated with genetic epilepsy with febrile seizures plus: clinical phenotype and genetic analysis of a Chinese pedigree.
18 Feb 2026· Frontiers in genetics· PUBMED
Publication
Characterizing early behavioral and social-emotional problems in young children with SCN1A+ Dravet syndrome: Findings from the ENVISION prospective natural history study.
2 Feb 2026· Epilepsia· PUBMED
Trial
A Study to Evaluate the Safety and Pharmacokinetics of RC001 in Children With Dravet Syndrome
22 Dec 2025· EARLY_PHASE1 · RECRUITING· CTGOV
Publication
Cognitive stagnation and executive function deficits in young children with SCN1A+ Dravet syndrome: Detailed characterization of onset, progression, and impact in the ENVISION natural history study.
17 Nov 2025· Epilepsia· PUBMED
Preprint
Epilepsy-associated Variants of a Single SCN1A Codon exhibit Divergent Functional Properties.
16 Oct 2025· bioRxiv : the preprint server for biology· PUBMED
Trial
Longitudinal Study of Phenotypic and Developmental Severity in Patients With Dravet Syndrome With SCN1A Gene Mutation
15 Sept 2025· NA · RECRUITING· CTGOV
Trial
Registry and Natural History of Epilepsy-Dyskinesia Syndromes
1 Jun 2025· NA · RECRUITING· CTGOV

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