Target

SHP2

Tyrosine-protein phosphatase non-receptor type 11

Also: PTPN11

0open trials
12trials in total
47publications
0researchers

Diseases

The last 24 months

New trials, publications, preprints and grants on this target, month by month.

TrialsPublicationsPreprintsGrants

Publication
Case Report: Discordant hypertrophic cardiomyopathy in monozygotic twins with LEOPARD syndrome and an identical PTPN11 c.1391G > C (p.Gly464Ala) mutation.
14 Oct 2026· Frontiers in cardiovascular medicine· PUBMED
Publication
QinZhuLiangXue gel alleviates psoriasiform inflammation through immunomodulatory effects involving PD-1/PD-L1/SHP2 signaling axis.
17 Sept 2026· Journal of ethnopharmacology· PUBMED
Publication
Corrigendum to "Structural and molecular insights into Helicobacter pylori CagA-SHP2 complex: From pathogenic signaling to targeted therapeutic opportunities in gastric cancer" [Microbiol. Res. (2026) 128632].
15 Sept 2026· Microbiological research· PUBMED
Publication
Inhibition of SHP2 enhances the effects of selective receptor tyrosine kinase inhibitors in untreated preclinical models of RET-mutated thyroid cancer.
27 Aug 2026· Investigational new drugs· PUBMED
Preprint
Modulation of the sensitivity to ruxolitinib-mediated JAK2 inhibition by mutationally activated SHP2 exhibits cell context dependency in pre-clinical models of myeloproliferative neoplasms.
20 Aug 2026· bioRxiv : the preprint server for biology· PUBMED
Publication
CD19 CAR-macrophage suppressed the progression of DLBCL via modulating SYK/SHP2/TBK1/TFEB signaling.
4 Aug 2026· Biochemical and biophysical research communications· PUBMED
Publication
Mechanistic evaluation of NSC 57774 as a SHP2 inhibitor in gastric cancer: Multi-pathway signaling modulation in vitro.
30 Jul 2026· PloS one· PUBMED
Publication
Identification of divergent PTPN11 mutations in canine histiocytic sarcomas reveals evidence of an independent clonal origin.
20 Jul 2026· PloS one· PUBMED
Publication
Structural and molecular insights into Helicobacter pylori CagA-SHP2 complex: From pathogenic signaling to targeted therapeutic opportunities in gastric cancer.
15 Jul 2026· Microbiological research· PUBMED
Publication
Mechanistic studies of tyrosine phosphatase SHP2 in hypoxic environment to promote angiogenesis in HCC by modulating the ROS/Src pathway.
8 Jul 2026· Scientific reports· PUBMED
Publication
SHP2 induced ferroptosis resistance in hepatocellular carcinoma via modulating CREB/EZH2/FOXO1 signaling induced autophagy/NCOA4/GPX4 protein expression.
1 Jul 2026· Scientific reports· PUBMED
Publication
Hesperidin suppressed high-fat diet induced obesity via modulating ROS/JNK/BRD4/SHP2 signaling induced lipogenesis.
25 Jun 2026· Scientific reports· PUBMED
Publication
Targeting GLP-1R and IL-17A suppresses obesity-induced leukemia in an oncogenic PTPN11 mutation-driven model.
23 Jun 2026· The Journal of clinical investigation· PUBMED
Publication
Hypoxia induced DNMT3B and SHP2 signaling promoted HCC via suppressing P53 and MYH11 protein expression.
15 Jun 2026· Frontiers in oncology· PUBMED
Publication
BGC1201: A potent allosteric SHP2 inhibitor with broad antitumor activity in lung, pancreatic, and esophageal cancer xenografts.
15 Jun 2026· Pharmaceutical science advances· PUBMED
Publication
SHP2 Inhibition Reveals Compensatory PI3K-AKT Activation in KRAS-Driven Pancreatic Cancer: Discovery of SDUY104 and Rational Approaches for Combination Therapy.
9 Jun 2026· Journal of medicinal chemistry· PUBMED
Publication
EphA2/SHP2/SOX8 Axis: A Novel Target for Regulation of Migration and Cetuximab Treatment Sensitivity in Oral Squamous Cell Carcinoma.
26 May 2026· Molecular carcinogenesis· PUBMED
Publication
The SHERPA trial: A phase I study combining SHP2 inhibitor RMC-4630 and ERK inhibitor LY3214996 in patients with KRAS-mutant pancreatic, non-small cell lung and colorectal cancer.
6 May 2026· European journal of cancer (Oxford, England : 1990)· PUBMED
Publication
SHP2 in TAMs promoted the survival of gastric adenocarcinoma via suppressing the P38/ERK1/2/SP1/BRD4/STING induced inflammation and ROS.
30 Apr 2026· Frontiers in medicine· PUBMED
Publication
RETRACTED: Richards et al. Protein Tyrosine Phosphatase Non-Receptor 11 (PTPN11/Shp2) as a Driver Oncogene and a Novel Therapeutic Target in Non-Small Cell Lung Cancer (NSCLC). Int. J. Mol. Sci. 2023, 24, 10545.
29 Apr 2026· International journal of molecular sciences· PUBMED
Publication
Blocking SHP2 benefits FGFR2 inhibitor and overcomes its resistance in FGFR2-amplified gastric cancer.
23 Mar 2026· eLife· PUBMED
Publication
Complex Genetic Architecture in RASopathies: Constitutional PTPN11 and Mosaic RIT1 Pathogenic Variants Underlying Severe Noonan Syndrome With Adult-Onset Acute Myeloid Leukemia.
22 Mar 2026· American journal of medical genetics. Part A· PUBMED
Publication
Novel Variants in PTPN11 , NF1 , RASA2 , and MAP2K1 : Expanding the Molecular Spectrum of RASopathies in a Turkish Cohort.
19 Mar 2026· Clinical genetics· PUBMED
Publication
ID1 in TAMs promoted the progression of non-small-cell carcinoma via increasing NF-κB/NPM1/SHP1/SHP2 signaling induced M2 polarization.
19 Mar 2026· Scientific reports· PUBMED
Publication
Functionally distinct ALK and ROS1 fusions detected in infant-type hemispheric gliomas converge on STAT3 and SHP2 activation.
5 Mar 2026· Cell reports· PUBMED
Publication
Durable disease control in a radiation-induced high-grade glioma harboring NF1 and PTPN11 co-mutations.
27 Feb 2026· Neuro-oncology advances· PUBMED
Publication
Characterization of the clonal hierarchy and immunophenotype of PTPN11 mutations in acute myeloid leukemia.
23 Feb 2026· JCI insight· PUBMED
Publication
Targeting MCL-1 and MAPK overcomes venetoclax resistance in FLT3-ITD-positive AML cells harbouring activating PTPN11 (SHP-2) mutations.
29 Jan 2026· British journal of haematology· PUBMED
Publication
SHP2 regulates VEGFR2 Y1175/PLCγ signaling to impair tumor endothelial barrier stability.
27 Jan 2026· iScience· PUBMED
Publication
SHP2 promotes osteosarcoma via regulating STAT3/TET3/HOXB2 signaling.
24 Jan 2026· Scientific reports· PUBMED

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