New trials, publications, preprints and grants on this target, month by month.
Publication
HIF-1α/PPAR-γ/SIRT1 axis drives astrocyte senescence and regulates endothelial function via GDNF/NRTN in diabetic retinopathy.
6 Nov 2026· PloS one· PUBMED
Publication
p97 inhibition attenuates cigarette Smoke-Induced lung inflammation and epithelial senescence by Restoring SIRT1 SUMOylation.
4 Nov 2026· Biochemical pharmacology· PUBMED
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Multi-scale computational analysis of MMP9 and SIRT1 regulatory networks and their interaction with curcumin and resveratrol in lung adenocarcinoma.
3 Nov 2026· In silico pharmacology· PUBMED
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Phytochemical investigation and neuroprotective effect of Encephalartos kisambo Faden & Beentje: Regulation of SIRT1, lnc-MALAT1, and vimentin in mice.
2 Nov 2026· Fitoterapia· PUBMED
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Resveratrol Modulates Bone Metabolism Through SIRT1-Mediated NF-κB Inhibition: Molecular Mechanisms and Therapeutic Implications.
1 Nov 2026· Cell biochemistry and function· PUBMED
Publication
SIRT1 Signaling in Alzheimer's Disease: Regulation of Mitochondrial Biogenesis and Therapeutic Implications.
31 Oct 2026· Pharmacological research· PUBMED
Publication
Zederone-calycosin ameliorates psoriasis via the AMPK/SIRT1/PGC-1α pathway: insights from the Astragali Radix-Curcumae Rhizoma herb pair.
30 Oct 2026· International immunopharmacology· PUBMED
Publication
Baicalin alleviates renal interstitial fibrosis by targeting SIRT1/HIF-1α signaling pathway.
27 Oct 2026· Journal of ethnopharmacology· PUBMED
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Stabilization of LTBP2 by SIRT1 promotes EMT and chemosensitivity in cardia gastric adenocarcinoma through TGF-β signaling.
27 Oct 2026· Oncogene· PUBMED
Publication
Hyperglycemia-Induced Loss of Astrocytic Kir4.1 Is Associated with Increased DNMT1 Activity and Altered AMPK/SIRT1 Signaling.
20 Oct 2026· Cells· PUBMED
Publication
Correction: Sinigrin, a bioactive compound from cruciferous vegetables, ameliorates MASLD by activating AMPK/SIRT1/PGC-1α to enhance fatty acid beta-oxidation.
19 Oct 2026· Food & function· PUBMED
Publication
Tirzepatide Attenuates Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension: Association with the SIRT1/H4K12la/c-Jun Axis.
19 Oct 2026· Cells· PUBMED
Publication
Caffeine and Exercise in Obesity-Associated Brain Aging and Neurodegeneration: Mechanistic Insights into AMPK/SIRT1/PGC-1α, BDNF/TrkB, and NLRP3 Inflammasome Signaling.
16 Oct 2026· Molecular neurobiology· PUBMED
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Research on the Regulatory Effects of Resveratrol on BCG-Induced Autophagy and Apoptosis in Macrophages via Targeting SIRT1.
15 Oct 2026· Microorganisms· PUBMED
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Intermedin attenuates chronic intermittent hypoxia-induced renal fibrosis via SIRT1-mediated inhibition of the NOX4/ROS axis.
12 Oct 2026· Biochemical pharmacology· PUBMED
Publication
The synergistic effects of resveratrol and nicotinamide on cell proliferation, apoptosis, and SIRT1 gene expression in human retinal pigment epithelial cells.
12 Oct 2026· Tissue & cell· PUBMED
Publication
Pseudomonas aeruginosa Pyocyanin Increases Airway Mucin Biosynthesis by SIRT1-Mediated FOXA2 Inactivation.
6 Oct 2026· International journal of molecular sciences· PUBMED
Publication
Therapeutic Window of AAV-SIRT1 Gene Therapy in Mouse Models of Optic Nerve Degeneration.
5 Oct 2026· Translational vision science & technology· PUBMED
Publication
Ferulic acid-mediated selenium nanoparticles attenuate oxaliplatin-induced renal injury in type 2 diabetic rats via modulation of oxidative stress, SIRT1/HMGB1/TLR4 signaling, endoplasmic reticulum stress, and apoptosis.
4 Oct 2026· Tissue & cell· PUBMED
Publication
Icariin Protects Against Mitochondrial Damage and Ferroptosis-Related Injury in Synovial Fibroblast-Like Synoviocytes Through SUMO1-Dependent Regulation of SIRT1.
1 Oct 2026· IUBMB life· PUBMED
Publication
Securidaca inappendiculata Extract Mitigates Joint Damage in Collagen-Induced Arthritis Rats Through Modulation of the SIRT1/HIF-1α/Glycolysis Pathway.
1 Oct 2026· Pharmacology research & perspectives· PUBMED
Publication
Therapeutic Potential of Pioglitazone in a Propionic Acid-Induced Rat Model of Autism Spectrum Disorder: The Role of the SIRT1/PPAR-γ Axis.
1 Oct 2026· International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience· PUBMED
Publication
Statement of Retraction: N6-methyladenosine (m6A) reader IGF2BP2 promotes gastric cancer progression via targeting SIRT1.
1 Oct 2026· Bioengineered· PUBMED
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Design, Synthesis, and Biological Evaluation of Pyrazolyl Thioureas (PTUs) as SIRT1 and SIRT2 Inhibitors.
28 Sept 2026· ChemMedChem· PUBMED
Publication
SIRT1-mediated deacetylation of TRIM21 promotes IRF5 degradation and restrains type I interferon signatures in Sjögren's disease.
23 Sept 2026· Translational research : the journal of laboratory and clinical medicine· PUBMED
Publication
Novel applications of SIRT1 in Chronic Kidney Disease.
23 Sept 2026· Frontiers in medicine· PUBMED
Publication
"Improving the beneficial effects of HDAC8 inhibition by simultaneously activation of SIRT1 in a zebrafish model of Duchenne muscular dystrophy.
20 Sept 2026· Pharmacological research· PUBMED
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Xinmailong Injection Attenuates Doxorubicin-Induced Chronic Heart Failure by Regulating the SIRT1/Caspase-3 Axis and Metabolic Reprogramming: An Integrative Network Pharmacology and Metabolomics Study.
18 Sept 2026· Current medical science· PUBMED
Publication
Agrimol B induces apoptosis and ferroptosis in acute monocytic leukemia by targeting EGFR/ERK1/2 signaling and activating SIRT1.
17 Sept 2026· Cancer treatment and research communications· PUBMED
Publication
Sasca D, Hähnel PS, Szybinski J, et al. SIRT1 prevents genotoxic stress-induced p53 activation in acute myeloid leukemia. Blood. 2014;124(1):121-133.
17 Sept 2026· Blood· PUBMED