Target

SOD1

Superoxide dismutase [Cu-Zn]

7open trials
17trials in total
138publications
0researchers

Diseases

ALS (motor neurone disease)17 trials
Frontotemporal dementia1 trial

The last 24 months

New trials, publications, preprints and grants on this target, month by month.

TrialsPublicationsPreprintsGrants

Publication
From multi-omics screening to functional validation: The SOD1-SIRT5 Axis as a potential mediator of ammonia-related neuronal injury and NAD⁺-based neuroprotection in epilepsy.
4 Nov 2026· Metabolic brain disease· PUBMED
Publication
HDAC inhibition drives NOX5-dependent oxidative stress and sensitizes uveal melanoma cells to SOD1 inhibition.
2 Nov 2026· The Journal of biological chemistry· PUBMED
Publication
Neural stem cell-derived small extracellular vesicles ameliorate disease progression in the SOD1 G93A murine model of amyotrophic lateral sclerosis.
1 Nov 2026· Journal of neuropathology and experimental neurology· PUBMED
Publication
Strain-specific morphology and CNS propagation of template-directed SOD1 aggregation following peripheral nerve inoculation.
28 Oct 2026· Acta neuropathologica communications· PUBMED
Publication
Intracisternal injection of two human SOD1 aggregate strains induces templated aggregation and ALS in transgenic mouse model.
27 Oct 2026· Acta neuropathologica communications· PUBMED
Publication
Identification of SOD1 Gene Variants in Mexican Patients with Amyotrophic Lateral Sclerosis.
15 Oct 2026· International journal of molecular sciences· PUBMED
Publication
The Role of SOD1 and Oxidative Stress in Amyotrophic Lateral Sclerosis: An Overview.
13 Oct 2026· International journal of molecular sciences· PUBMED
Publication
SOD1 co-pathologies in the brain: insights from neuropathological evidence and implications.
6 Oct 2026· Acta neuropathologica· PUBMED
Publication
Phenotypic Profiling of SOD1-G93A Mice: Integrating Sciatic Nerve Histopathology with Systemic Chemokine Dynamics During ALS Progression.
25 Sept 2026· International journal of molecular sciences· PUBMED
Publication
SOD1:c.118G>A mutation in the Cimarrón Uruguayo dog: prevalence, drift dynamics, and structural effects.
11 Sept 2026· Brazilian journal of veterinary medicine· PUBMED
Publication
The role of overdose folic acid in promoting neuroinflammation, oxidative stress, and apoptosis in SOD1-G93A mice.
10 Sept 2026· Free radical research· PUBMED
Publication
Cognitive and Behavioural Profile of SOD1-ALS Across the ALS-FTD Spectrum: A Systematic Review.
7 Sept 2026· International journal of molecular sciences· PUBMED
Preprint
Defective synapto-nuclear signaling contributes to motoneuron vulnerability in SOD1-ALS.
4 Sept 2026· bioRxiv : the preprint server for biology· PUBMED
Publication
Multisite Anodal Direct Current Stimulation Preserves Motor Function and Modulates Key Cellular Pathways in TDP-43 and SOD1 Mouse Models of Amyotrophic Lateral Sclerosis.
3 Sept 2026· Neuromodulation : journal of the International Neuromodulation Society· PUBMED
Publication
Seeds from ALS patients homozygous for the SOD1 D90A mutation transmit two types of SOD1 aggregation and motor neuron disease.
1 Sept 2026· Acta neuropathologica· PUBMED
Publication
Antisense Oligonucleotide Tofersen Distribution in the Central Nervous System of SOD1-ALS Autopsy Tissue Donors.
1 Sept 2026· JAMA neurology· PUBMED
Publication
The HDAC Inhibitor Butyrate Reduces SOD1 Aggregation and Improves Motor Function in C. elegans and Cellular Models of ALS.
27 Aug 2026· International journal of cell biology· PUBMED
Publication
Population-Level Nucleotide Diversity and Genetic Differentiation at SOD1 Across Global Human Populations.
17 Aug 2026· Annals of human genetics· PUBMED
Publication
Severe hypersensitivity reaction during tofersen therapy in amyotrophic lateral sclerosis associated with the rare SOD1 p.Val120Phe mutation.
13 Aug 2026· Neurologia i neurochirurgia polska· PUBMED
Publication
Nuclear SOD1 links ATM-CHK2 signaling to ADH5/GSNOR transcription in SHSY-5Y SOD1G93A cellular models of ALS.
12 Aug 2026· Nitric oxide : biology and chemistry· PUBMED
Publication
Blood SOD1 Activity in ALS Patients Receiving Tofersen Treatment.
11 Aug 2026· Annals of neurology· PUBMED
Publication
Generation of mutant human SOD1 knock-in mouse lines at the Rosa26 locus as a platform for developing genome-editing therapies for amyotrophic lateral sclerosis.
8 Aug 2026· Experimental animals· PUBMED
Publication
Targeting Mitochondrial Fission Produces Both Neuroprotective and Detrimental Effects in the SOD1 Mouse Model of Amyotrophic Lateral Sclerosis.
7 Aug 2026· Biology· PUBMED
Publication
Cerebellar ataxia-onset ALS with SOD1 D91A mutation: a rare phenotype.
4 Aug 2026· Frontiers in neurology· PUBMED
Publication
SOD1 Variants in Patients With Amyotrophic Lateral Sclerosis in Central Eastern Europe: From Genetic Testing to SOD1 Targeted Therapy.
1 Aug 2026· European journal of neurology· PUBMED
Publication
Oxidative Stress Markers and Divergent SOD1/SOD2 mRNA Expression in Type 2 Diabetes: A Case-Control Study.
1 Aug 2026· International journal of molecular and cellular medicine· PUBMED
Publication
Paris saponin VII promotes TRIP12-mediated SOD1 degradation to synergize with idarubicin in ROS-dependent acute myeloid leukemia cell death.
29 Jul 2026· Phytomedicine : international journal of phytotherapy and phytopharmacology· PUBMED
Publication
Tofersen treatment in respiratory onset amyotrophic lateral sclerosis and a variant of uncertain significance in SOD1; a case report.
28 Jul 2026· European journal of human genetics : EJHG· PUBMED
Publication
Antisense oligonucleotide treatment following viral delivery of artificial SOD1-targeting miRNA shows improved efficacy in SOD1-G93A mice.
24 Jul 2026· Molecular therapy. Advances· PUBMED
Publication
A Blood-Derived Factor Rescues ALS: Platelet Factor 4 Activates OPTN-Dependent Autophagy to Clear SOD1 Aggregates Independently of PINK1.
23 Jul 2026· Advanced science (Weinheim, Baden-Wurttemberg, Germany)· PUBMED

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