Target
TDP-43
TAR DNA-binding protein 43
- 9open trials
- 16trials in total
- 261publications
- 0researchers
Diseases
- ALS (motor neurone disease)13 trials
- Frontotemporal dementia7 trials
- Alzheimer disease2 trials
- Parkinson disease1 trial
The last 24 months
New trials, publications, preprints and grants on this target, month by month.
TrialsPublicationsPreprintsGrants
Trial
Personalized Antisense Oligonucleotide Therapy for a Participant With TARDBP ALS
Publication
Publication
Cofilin hyperphosphorylation triggers TDP-43 pathology in sporadic amyotrophic lateral sclerosis.
Publication
The TNKS/PI31-proteasome axis as a central node in TDP-43 neuropathies.
Publication
Transcriptomic signature of frontotemporal lobar degeneration with TDP-43 type C pathology.
Publication
Publication
Disease progression in probable limbic-predominant age-related TDP-43 encephalopathy.
Publication
TDP-43 dysfunction destabilizes glial homeostatic identity in ALS/FTD.
Publication
A closer look at LATE: a Case Report on a subtly evolving neurodegenerative disorder.
Publication
Cytoplasmic TDP-43 Accumulation in Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay.
Publication
Cryo-EM advances in TDP-43 amyloid fibrils structure determination.
Publication
Publication
Publication
Publication
Multiple motor proteins regulate TDP-43 anterograde axonal transport.
Publication
Scp160 deletion suppresses TDP-43 aggregation and toxicity in Saccharomyces cerevisiae.
Publication
Publication
Preprint
ALS/FTD-linked TDP-43 alterations prevent HSV-1 infection by disrupting cell-adhesion pathways.
Trial
Publication
Polygenic risk scores for LATE-neuropathologic change: Implications for clinical utility.
Publication
Preprint
Publication
TDP-43-Associated Neurodegenerative Disease Conceptualization and Integrated Staging: A Review.
Publication
LRSAM1, an E3 ubiquitin ligase, modulates TDP-43 proteostasis in amyotrophic lateral sclerosis.
Publication
KIF4A stabilizes TDP43 to promote DNA damage repair and temozolomide resistance in glioblastoma.
Preprint
Loss of TDP-43 function drives cryptic circular RNAs in neurodegenerative diseases.
Preprint
TDP-43 dysfunction induces cryptic circular RNAs in ALS/FTD.
Preprint
Restoring multiple TDP-43 cryptic targets, but not solely Unc13a , rescues motor neuron disease.
Publication
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